Shock Wave Versus Low Level Laser on Chronic Venous Ulcer

NANot yet recruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

January 1, 2025

Primary Completion Date

June 1, 2025

Study Completion Date

July 1, 2025

Conditions
Venous Ulcer
Interventions
DEVICE

extra corporeal shock wave therapy (ESWT )

Using wound area measurements and histological/immunohistochemical analysis of wound biopsies, we show ESWT enhanced healing of chronic ulcers associated with improved wound angiogenesis ), significantly decreased-positive macrophages per biopsy area and generally increased macrophage activity ,this activity prevent bacterial infection which delay healing

DEVICE

Low Level Laser Therapy

"Low-level laser therapy (LLLT) has been used as an adjuvant to conventional therapy with promising results,improve healing by delivering nutrient substances , especially in patients with acute and bloody ulcers.~Positive effects include acceleration of tissue repair, increased formation of granulation tissue, wound contraction, inflammation modulation, and pain reduction The biochemical effects of LLLT are associated with the release of preformed substances (histamine, serotonin, and bradykinin), which stimulate the production of ATP and inhibit the production of prostaglandins."

OTHER

conservative treatments

( compression pandaging, lifestyle changes, physical activities)

All Listed Sponsors
lead

Beni-Suef University

OTHER

NCT06756386 - Shock Wave Versus Low Level Laser on Chronic Venous Ulcer | Biotech Hunter | Biotech Hunter