The Role of Sugars in Fat Accumulation in the Liver

NARecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

June 20, 2024

Primary Completion Date

March 31, 2027

Study Completion Date

March 31, 2027

Conditions
Fatty Liver Disease
Interventions
DIETARY_SUPPLEMENT

150g of fat with glucose

The subjects will receive 460 ml of cream (high fat load - 150g of fat in total) with fruit tea sweetened with 50 g of glucose. Two and four hours later they will receive again fruit tea sweetened with the same sugar as at time 0 h. During the day, the subjects will not receive any food and they will be allowed to drink only water or fruit tea.

DIETARY_SUPPLEMENT

150g of fat with fructose

Description: The subjects will receive 460 ml of cream (high fat load - 150g of fat in total) with fruit tea sweetened with 50 g of fructose. Two and four hours later they will receive again fruit tea sweetened with the same sugar as at time 0 h. During the day, the subjects will not receive any food and they will be allowed to drink only water or fruit tea.

DIETARY_SUPPLEMENT

150g of fat with sucrose

The subjects will receive 460 ml of cream (high fat load - 150g of fat in total) with fruit tea sweetened with 50 g of sucrose. Two and four hours later they will receive again fruit tea sweetened with the same sugar as at time 0 h. During the day, the subjects will not receive any food and they will be allowed to drink only water or fruit tea.

DIETARY_SUPPLEMENT

Short-term (7 days) fructose restriction

Subjects will receive a package of glucose and selected foods without fructose to supplement their diet. For seven days they then will adhere to the diet without fructose and keep the detailed dietary record.

Trial Locations (1)

14021

RECRUITING

Institute for Clinical and Experimental Medicine, Prague

All Listed Sponsors
collaborator

Czech Health Research Council

UNKNOWN

lead

Institute for Clinical and Experimental Medicine

OTHER_GOV