A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy

PHASE3RecruitingINTERVENTIONAL
Enrollment

700

Participants

Timeline

Start Date

December 12, 2024

Primary Completion Date

December 15, 2027

Study Completion Date

April 13, 2029

Conditions
Colorectal Neoplasms
Interventions
BIOLOGICAL

Amivantamab

Amivantamab will be administered.

BIOLOGICAL

Cetuximab

Cetuximab will be administered.

BIOLOGICAL

Bevacizumab

Bevacizumab will be administered.

DRUG

5-fluorouracil

5-fluorouracil will be administered as chemotherapy regimen.

DRUG

Leucovorin calcium/Levoleucovorin

Leucovorin calcium/Levoleucovorin will be administered as chemotherapy regimen.

DRUG

Irinotecan

Irinotecan will be administered as chemotherapy regimen.

Trial Locations (217)

112

RECRUITING

Taipei Veterans General Hospital, Taipei

333

RECRUITING

Linkou Chang Gung Memorial Hospital, Taoyuan District

704

RECRUITING

National Cheng Kung University Hospital, Tainan City

833

RECRUITING

Chang Gung Memorial Hospital, Kaohsiung City

1070

RECRUITING

Institut Jules Bordet, Anderlecht

2139

RECRUITING

Concord Hospital, Concord

2650

RECRUITING

UZ Antwerpen, Edegem

3000

RECRUITING

Universitair Ziekenhuis Leuven, Leuven

3021

RECRUITING

Western Health Sunshine Hospital, St Albans

3084

RECRUITING

Warringal Private Hospital, Heidelberg

3300

RECRUITING

Markhot Ferenc Oktatokorhaz es Rendelointezet, Eger

4000

RECRUITING

Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman, Liège

5011

RECRUITING

Queen Elizabeth Hospital, South Woodville

6720

RECRUITING

Szegedi Tudomanyegyetem, Szeged

7100

RECRUITING

Jolimont, Haine Saint Paul La Louviere

7624

RECRUITING

Pecsi Tudomanyegyetem, Pécs

8500

RECRUITING

Az Groeninge, Kortrijk

9000

RECRUITING

AZ Maria Middelares, Ghent

10016

RECRUITING

NYU Langone Medical Center NYU Hematology Associates, New York

10043

RECRUITING

National Taiwan University Hospital, Taipei

10400

RECRUITING

Ramathibodi Hospital, Bangkok

10450

RECRUITING

Hospital Pulau Pinang, George Town

10461

RECRUITING

Montefiore Einstein Comprehensive Cancer Center, The Bronx

10700

RECRUITING

Siriraj Hospital, Bangkok

11501

RECRUITING

Perlmutter Cancer Center at NYU Long Island, Mineola

11967

RECRUITING

New York Cancer and Blood Specialists, Shirley

13353

RECRUITING

Charite Universitatsmedizin Berlin Campus Virchow Klinikum, Berlin

19096

RECRUITING

Alliance Cancer Specialists at Main Line, Penn Wynne

19107

RECRUITING

Thomas Jefferson University, Philadelphia

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

20089

RECRUITING

Istituto Clinico Humanitas, Rozzano

20133

RECRUITING

Istituto Dei Tumori Di Milano, Milan

21237

SUSPENDED

MedStar Franklin Square Medical Center, Baltimore

22010

RECRUITING

COI Centro Oncologico Internacional Tijuana, Tijuana

22201

RECRUITING

Virginia Cancer Specialists, Arlington

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

28007

RECRUITING

Hosp. Gral. Univ. Gregorio Maranon, Madrid

28034

RECRUITING

Hosp. Univ. Ramon Y Cajal, Madrid

28041

RECRUITING

Hosp. Univ. 12 de Octubre, Madrid

30303

RECRUITING

Grady Memorial Hospital, Atlanta

30318

RECRUITING

Piedmont Cancer Institute, Atlanta

30322

RECRUITING

Winship Cancer Institute Emory University, Atlanta

30450

RECRUITING

Hospital Raja Permaisuri Bainun, Ipoh

30607

RECRUITING

University Cancer And Blood Center LLC, Athens

31008

RECRUITING

Clinica Univ. de Navarra, Pamplona

31217

RECRUITING

Centro Oncologico de Chihuahua, Chihuahua City

32804

RECRUITING

AdventHealth Cancer Institute, Orlando

33100

RECRUITING

Azienda Sanitaria Universitaria Friuli Centrale ASU FC, Udine

33140

RECRUITING

Mount Sinai Medical Center Campus, Miami Beach

33604

RECRUITING

Hopital Haut Leveque, Pessac

33705

RECRUITING

Florida Cancer Specialists North Region, St. Petersburg

33901

RECRUITING

Florida Cancer Specialists South, Fort Myers

34147

RECRUITING

Bakirkoy Training and Research Hospital, Istanbul

34899

RECRUITING

Marmara University Pendik Training Hospital, Istanbul

35128

RECRUITING

Istituto Oncologico Veneto - IRCCS, Padua

37203

RECRUITING

SCRI Oncology Partners, Nashville

RECRUITING

Tennessee Oncology, Nashville

37404

RECRUITING

Tennessee Oncology, Chattanooga

39401

RECRUITING

Hattiesburg Clinic, Hattiesburg

40705

RECRUITING

Taichung Veterans General Hospital, Taichung

41013

RECRUITING

Hosp. Virgen Del Rocio, Seville

41404

RECRUITING

Kyungpook National University Chilgok Hospital, Daegu

42080

RECRUITING

Necmettin Erbakan University Meram Medical Faculty, Konya

44106

RECRUITING

University Hospital of Cleveland, Cleveland

44680

RECRUITING

Actualidad Basada En La Investigacion Del Cancer, Guadalajara

46010

RECRUITING

Hosp. Clinico Univ. de Valencia, Valencia

48109

RECRUITING

University of Michigan Rogel Cancer Center, Ann Arbor

48202

RECRUITING

Henry Ford Hospital, Detroit

49503

RECRUITING

Cancer And Hematology Centers of Western Michigan PC, Grand Rapids

50200

RECRUITING

Chiang Mai University, Chiang Mai

50586

RECRUITING

Hospital Kuala Lumpur, Kuala Lumpur

52621

RECRUITING

Sheba Medical Center, Ramat Gan

54290

RECRUITING

Sakarya University Training and Research Hospital, Sakarya

55131

RECRUITING

Universitatsmedizin der Johannes Gutenberg Universitat Mainz, Mainz

56126

RECRUITING

Azienda Ospedaliero Universitaria Pisana, Pisa

59100

RECRUITING

University Malaya Medical Centre, Kuala Lumpur

60488

RECRUITING

Krankenhaus NorthWest, Frankfurt am Main

62250

RECRUITING

Institut Kanser Negara Clinical Research Center, Putrajaya

63110

RECRUITING

Washington University School Of Medicine, St Louis

64460

RECRUITING

Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey

68130

RECRUITING

Nebraska Cancer Specialists, Omaha

69120

RECRUITING

National Center for Tumor Diseases NCT, Heidelberg

69710

RECRUITING

Assuta MC, Tel Aviv

70300

RECRUITING

Yitzhak Shamir Medical Center, Beer Yaakov

70809

RECRUITING

Mary Bird Perkins Cancer Center, Baton Rouge

72401

RECRUITING

St. Bernard's Medical Center, Jonesboro

72530

RECRUITING

Oncocenter, Puebla City

75246

RECRUITING

Texas Oncology DFW, Dallas

75701

RECRUITING

UT Health East Texas HOPE Cancer Center, Tyler

76000

RECRUITING

Cuidados Oncologicos, Querétaro

76230

RECRUITING

Health Pharma Queretaro SA de CV, Querétaro

76508

RECRUITING

Scott And White Memorial Hospital, Temple

77030

RECRUITING

MD Anderson Cancer Center, Houston

78240

RECRUITING

Texas Oncology - San Antonio, San Antonio

79606

RECRUITING

Texas Oncology West Texas, Abilene

80045

RECRUITING

University of Colorado Denver Anschultz Medical Campus, Aurora

80218

RECRUITING

Rocky Mountain Cancer Centers, Denver

80756

RECRUITING

Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung City

81377

RECRUITING

Klinikum der Universitaet Muenchen, Munich

84918

RECRUITING

Institut Sainte Catherine, Avignon

85224

RECRUITING

Ironwood Cancer and Research Center, Chandler

85234

RECRUITING

Banner MD Anderson Cancer Center, Gilbert

86000

RECRUITING

CHU De Poitiers, Poitiers

86301

RECRUITING

Arizona Oncology Associates PC NAHOA, Prescott

90033

RECRUITING

USC Norris Comprehensive Cancer Center, Los Angeles

90110

RECRUITING

Songklanagarind hospital, Songkhla

90404

RECRUITING

UCLA, Santa Monica

90505

RECRUITING

Torrance Memorial Physicians Network, Torrance

90720

RECRUITING

Cancer and Blood Specialty Clinic, Los Alamitos

91204

RECRUITING

Los Angeles Cancer Network, Glendale

93309

RECRUITING

CBCC Global Research, Bakersfield

93586

RECRUITING

Hospital Umum Sarawak, Kuching

95403

RECRUITING

Providence Medical Foundation, Santa Rosa

98109

RECRUITING

Fred Hutchinson Cancer Research Center, Seattle

98503

RECRUITING

Providence Regional Cancer System, Lacey

100034

RECRUITING

Peking University First Hospital, Beijing

100050

RECRUITING

Beijing Friendship Hospital Capital Medical University, Beijing

100142

RECRUITING

Beijing Cancer Hospital, Beijing

RECRUITING

Sun Yat Sen University Cancer Center, Guangzhou

110042

RECRUITING

Liaoning Cancer Hospital and Institute, Shenyang

110085

RECRUITING

Rajiv Gandhi Cancer Institute and Research Centre, Delhi

130021

RECRUITING

The First Bethune Hospital of Jilin University, Changchun

150081

RECRUITING

Harbin medical university cancer hospital, Harbin

200032

RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

200542

RECRUITING

Clinica de Oncologie Sf Nectarie, Craiova

221005

RECRUITING

Mahamana Pandit Madan Mohan Malviya Cancer Centre, Varanasi

300060

RECRUITING

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310009

RECRUITING

The Second Affiliated Hospital of Zhejiang University, Hangzhou

310022

RECRUITING

Zhejiang Cancer Hospital, Hangzhou

330006

RECRUITING

The First Affiliated Hospital of NanChang University, Nanchang

341000

RECRUITING

Ganzhou Cancer Hospital, Ganzhou

400012

RECRUITING

Tata Memorial Hospital, Mumbai

410013

RECRUITING

Hunan Cancer hospital, Changsha

410469

RECRUITING

Pelican Impex SRL, Oradea

411004

RECRUITING

Deenanath Mangeshkar Hospital and Research Centre, Pune

430079

RECRUITING

Hubei Cancer Hospital, Wuhan

500032

RECRUITING

Asian Institute Of Gastroenterology, Hyderabad

500091

RECRUITING

Centrul Medical Unirea SRL, Brasov

510655

RECRUITING

The Sixth Affiliated Hospital Sun Yat sen University, Guangzhou

516001

RECRUITING

Huizhou Central People's Hospital, Huizhou

519041

RECRUITING

Guangdong Provincial People's Hospital, Guangzhou

610041

RECRUITING

West China Hospital of Sichuan University, Chengdu

632004

RECRUITING

Christian medical, Vellore

700053

RECRUITING

B P Poddar Hospital and Medical research Limited, Kolkata

730050

RECRUITING

Gansu Provincial Cancer Hospital, Lanzhou

3109601

RECRUITING

Rambam Medical Center, Haifa

4941492

RECRUITING

Rabin Medical Center, Petah Tikva

6423906

RECRUITING

Tel Aviv Sourasky Medical Center, Tel Aviv

9112001

RECRUITING

Hadassah Medical Center, Jerusalem

06360

RECRUITING

Eastern Connecticut Hematology & Oncology Assoc., Norwich

33401-3406

RECRUITING

Florida Cancer Specialists East, West Palm Beach

08816

RECRUITING

Astera Cancer Care, East Brunswick

15232 1301

RECRUITING

University Of Pittsburgh Medical Center UPMC Hillman Cancer Center, Pittsburgh

14780 070

RECRUITING

Fundacao Pio XII, Barretos

95070 560

RECRUITING

Fundacao Universidade de Caxias do Sul, Caxias do Sul

17210 080

RECRUITING

Fundacao Doutor Amaral Carvalho, Jaú

91350 200

RECRUITING

Hospital Nossa Senhora da Conceicao S A, Porto Alegre

40050 410

RECRUITING

Hospital Santa Izabel Santa Casa de Misericordia da Bahia, Salvador

15090 000

RECRUITING

Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base, São José do Rio Preto

01246 000

RECRUITING

Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo, São Paulo

01509 900

RECRUITING

Fundacao Antonio Prudente A C Camargo Cancer Center, São Paulo

29043 260

RECRUITING

Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia, Vitória

Unknown

RECRUITING

Queen Mary Hospital, Hong Kong

RECRUITING

Prince Of Wales Hospital, Shatin

260 0801

RECRUITING

Chiba Cancer Center, Chiba

104 0045

RECRUITING

National Cancer Center Hospital, Chūōku

277 8577

RECRUITING

National Cancer Center Hospital East, Kashiwa

464 8681

RECRUITING

Aichi Cancer Center, Nagoya

540 0006

RECRUITING

National Hospital Organization Osaka National Hospital, Osaka

541 8567

RECRUITING

Osaka International Cancer Institute, Osaka

589 8511

RECRUITING

Kindai University Hospital, Osaka Sayama Shi

411 8777

RECRUITING

Shizuoka Cancer Center, Shizuoka

565 0871

RECRUITING

The University of Osaka Hospital, Suita

135 8550

RECRUITING

The Cancer Institute Hospital of JFCR, Tokyo

06760

RECRUITING

Centro Oncologico Personalizado Cope S De R L De C V, Mexico City

3813 TZ

RECRUITING

Meander Medisch Centrum, Amersfoort

1066 CX

RECRUITING

Antoni van Leeuwenhoek, Amsterdam

6525 GA

RECRUITING

Radboud University Medical Center, Nijmegen

3015 GD

RECRUITING

Erasmus MC, Rotterdam

5042 AD

RECRUITING

ETZ TweeSteden, Tilburg

15 027

RECRUITING

Bialostockie Centrum Onkologii im Marii Sklodowskiej Curie w Bialymstoku, Bialystok

21 500

RECRUITING

Wojewodzki Szpital Specjalistyczny, Biała Podlaska

36 200

RECRUITING

Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza, Brzozów

80 214

RECRUITING

Uniwersyteckie Centrum Kliniczne, Gdansk

44 100

RECRUITING

Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach, Gliwice

93 339

RECRUITING

Instytut Centrum Zdrowia Matki Polki, Lodz

10 228

RECRUITING

SPZOZ Ministerstwa Spraw Wewnetrznych z Warminsko Mazurskim Centrum Onkologii w Olsztynie, Olsztyn

45 061

RECRUITING

SPZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarowskiego, Opole

02 034

RECRUITING

Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warsaw

00935

RECRUITING

Pan American Center for Oncology Trials LLC, San Juan

013812

RECRUITING

Spitalul Memorial Baneasa, Bucharest

014142

RECRUITING

Ponderas Academic Hospital, Bucharest

02841

RECRUITING

Korea University Anam Hospital, Seoul

03080

RECRUITING

Seoul National University Hospital, Seoul

03722

RECRUITING

Severance Hospital Yonsei University Health System, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

06591

RECRUITING

The Catholic University of Korea Seoul St Mary s Hospital, Seoul

08025

RECRUITING

Hosp. de La Santa Creu I Sant Pau, Barcelona

08035

RECRUITING

Hosp Univ Vall D Hebron, Barcelona

413 45

RECRUITING

Sahlgrenska Universitetssjukhuset, Gothenburg

222 42

RECRUITING

Skanes universitetssjukhus, Lund

118 83

RECRUITING

Sodersjukhuset, Stockholm

171 76

RECRUITING

Karolinska Universitetssjukhuset, Stockholm

SE 751 85

RECRUITING

Uppsala University, Uppsala

01060

RECRUITING

Adana City Hospital, Adana

06010

RECRUITING

Gulhane Egitim ve Arastirma Hastanesi, Ankara

06200

RECRUITING

Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara

06560

RECRUITING

Gazi University Hospital, Ankara

06800

RECRUITING

Ankara Bilkent Sehir Hastanesi, Ankara

B9 5ST

RECRUITING

Birmingham Heartlands Hospital, Birmingham

HU16 5JQ

RECRUITING

Castle Hill Hospital, Hull

LS9 7TF

RECRUITING

St James University Hospital, Leeds

EC1A 7BE

RECRUITING

St Bartholomew's Hospital, London

NW1 2BU

RECRUITING

University College Hospital, London

SW3 6JJ

RECRUITING

Royal Marsden Hospital, London

HA6 2RN

RECRUITING

Mount Vernon Cancer Centre, Northwood

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY