Clinical Study on the Application of Lactulose Combined with Linaclotide in Bowel Preparation for Colonoscopy

PHASE4Enrolling by invitationINTERVENTIONAL
Enrollment

444

Participants

Timeline

Start Date

September 1, 2024

Primary Completion Date

October 1, 2025

Study Completion Date

October 1, 2025

Conditions
LactuloseBowel Preparation
Interventions
DRUG

Lactulose

At 20:00 the night before the examination, pour 2 boxes of lactilose into a cup, add 1000ml of water and drink it; 4 to 6 hours before the examination, dissolve the third box of lactulose into 1000ml water, and drink it; Until pale yellow or clear dung water is drawn.

DRUG

Lactulose+ linaclotide

1 capsule of linalotide (290ug) taken orally half an hour before meal at 12:00 noon on the previous day, and two doses were taken after 20:00 according to the above Lactulose-taking method.

DRUG

polyethylene glycol (PEG)

a bag of PEG was dissolved into 1L at 20:00 1d before the examination, and was drunk at a constant rate within 2h; 4 to 6 hours before the inspection, dissolve the second bag of PEG into 2L water and drink it.

Trial Locations (1)

210000

Jinling Hospital, China, Nanjing

All Listed Sponsors
lead

Haifeng Lan

OTHER