A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

March 5, 2025

Primary Completion Date

March 31, 2029

Study Completion Date

October 30, 2032

Conditions
Mantle Cell LymphomaB Cell Lymphoma
Interventions
DRUG

Sonrotoclax

Administered orally

DRUG

Zanubrutinib

Administered orally

DRUG

Placebo

Administered orally

Trial Locations (148)

1090

NOT_YET_RECRUITING

Medical University Vienna Oncology, Vienna

1413

NOT_YET_RECRUITING

Hospital Italiano de Buenos Aires, Ciudad Autonoma Buenos Aires

1425

RECRUITING

Hospital Aleman, CABA

3100

RECRUITING

Uk St Poelten, Sankt Pölten

3112

RECRUITING

Tauranga Hospital, Tauranga

4020

RECRUITING

Ordensklinikum Linz Gmbh Elisabethinen, Linz

5020

RECRUITING

Universitatsklinik Fur Innere Medizin Iii Universitatsklinikum Der Pmu Landeskrankenhaus Salzburg, Salzburg

6021

NOT_YET_RECRUITING

Wellington Regional Hospital (Ccdhb), Wellington

8011

RECRUITING

Christchurch Hospital, Christchurch

8036

RECRUITING

Hospital Clinic de Barcelona, Barcelona

9016

RECRUITING

Dunedin Hospital, Dunedin

13620

RECRUITING

Seoul National University Bundang Hospital, BundangGu SeongnamSi

17033

RECRUITING

Penn State Milton S Hershey Medical Center, Hershey

20251

NOT_YET_RECRUITING

Universitatsklinikum Hamburg Eppendorf, Hamburg

27157

RECRUITING

Atrium Health Wake Forest Baptist, Winston-Salem

27710

NOT_YET_RECRUITING

Duke University, Durham

28040

RECRUITING

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28222

RECRUITING

H Puerta de Hierro Majadahonda, Majadahonda

34090

RECRUITING

Chu Montpellier Hopital Saint Eloi, Montpellier

34129

RECRUITING

Azienda Sanitaria Universitaria Giuliano Isontina, Trieste

37000

RECRUITING

Chu Tours Hopital Bretonneau, Tours

37134

RECRUITING

Centroricerche Cliniche Di Verona Srl, Verona

37205

RECRUITING

Tennessee Oncology, Nashville

37404

RECRUITING

Tennesse Oncology Chattanooga Downtown, Chattanooga

40138

RECRUITING

Policlinico Sorsola Malpighi, Aou Di Bologna, Bologna

41380

RECRUITING

Kocaeli Universitesi Tip Fakultesi, Kocaeli

44000

RECRUITING

Centre Hospitalier Universitaire Nantes Hotel Dieu, Nantes

46804

RECRUITING

Fort Wayne Medical Oncology and Hematology, Fort Wayne

47014

RECRUITING

Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori Irst, Meldola

49241

RECRUITING

Pusan National University Hospital, Seogu

50263

RECRUITING

Mission Cancer and Blood, Waukee

60596

NOT_YET_RECRUITING

Klinikum Der Johann Wolfgang Goethe Universitat, Frankfurt am Main

60612

NOT_YET_RECRUITING

Rush University Medical Center, Chicago

69495

RECRUITING

Chu Hopital Lyon Sud, PierreBenite

73100

RECRUITING

Ospedale Vito Fazzi, Asl Lecce, Leece

73557

RECRUITING

Stauferklinikum Schwabisch Gmund Kliniken Ostalb, Mutlangen

81377

NOT_YET_RECRUITING

Dept of Medicine Iii, University Hospitallmu, München

100142

RECRUITING

Beijing Cancer Hospital, Beijing

100730

RECRUITING

Beijing Hospital, Beijing

110042

RECRUITING

Liaoning Cancer Hospital and Institute, Shenyang

150000

RECRUITING

Harbin Medical University Cancer Hospital, Harbin

200000

RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

210029

RECRUITING

Jiangsu Province Hospital, Nanjing

221000

RECRUITING

The Affiliated Hospital of Xuzhou Medical University, Xuzhou

266555

RECRUITING

The Affiliated Hospital of Qingdao University Branch West Coast, Qingdao

276001

RECRUITING

Linyi Cancer Hospital, Linyi

310002

RECRUITING

The First Affiliated Hospital, Zhejiang University School of Medicinechengzhan, Hangzhou

325000

RECRUITING

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

330029

RECRUITING

Jiangxi Province Cancer Hospital, Nanchang

350001

RECRUITING

Fujian Medical University Union Hospital, Fuzhou

430022

RECRUITING

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430030

RECRUITING

Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan

450052

RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

510060

RECRUITING

Sun Yat Sen University Cancer Center, Guangzhou

510515

RECRUITING

Nanfang Hospital of Southern Medical University, Guangzhou

610071

RECRUITING

Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital, Chengdu

630014

RECRUITING

The First Affiliated Hospital of Chongqing Medical University, Chongqing

710068

RECRUITING

Shaanxi Provincial Peoples Hospital, Xi'an

35294-0004

RECRUITING

University of Alabama At Birmingham Hospital, Birmingham

85054-4502

RECRUITING

Mayo Clinic Phoenix, Phoenix

06520-8028

RECRUITING

Yale University, Yale Cancer Center, New Haven

33026-4119

RECRUITING

Memorial Cancer Institute, Memorial Healthcare System, Pembroke Pines

33331-3609

RECRUITING

Cleveland Clinic Florida, Weston

21201-1544

RECRUITING

University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore

02215-5418

RECRUITING

Dana Farber Cancer Institute Longwood Medical Center, Boston

48109-1382

NOT_YET_RECRUITING

University of Michigan, Ann Arbor

49503-2563

RECRUITING

The Cancer and Hematology Centers, Grand Rapids

55905-0001

RECRUITING

Mayo Clinic Rochester, Rochester

39401-7233

RECRUITING

Hattiesburg Hematology and Oncology Clinic, Hattiesburg

63110-1010

RECRUITING

Washington University School of Medicine, St Louis

07652

RECRUITING

The Valley Hospital, Inc, Paramus

28204-2990

RECRUITING

Atrium Health Levine Cancer Institute (Lci), Charlotte

44106-1716

RECRUITING

University Hospitals, Cleveland

44195-0001

NOT_YET_RECRUITING

Cleveland Clinic Foundation, Cleveland

43210-1280

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

43214-3907

RECRUITING

Ohio Health Research Institute, Columbus

19611-2143

RECRUITING

McGlinn Cancer Institute, West Reading

77030-3907

RECRUITING

Md Anderson Cancer Center, Houston

78681-4019

RECRUITING

Texas Oncology Austin Midtown, Round Rock

22908-0817

RECRUITING

University of Virginia, Charlottesville

20155-3257

RECRUITING

Virgina Cancer Specialists, Gainesville

23298-5026

RECRUITING

Vcu Massey Cancer Center, Richmond

98684-6930

RECRUITING

Northwest Cancer Specialist, Pc(Us Oncology Research), Vancouver

CP1114

NOT_YET_RECRUITING

FUNDALEU, Caba

X5000HUA

NOT_YET_RECRUITING

Hospital Universitario de Cordoba, Córdoba

NSW 2139

RECRUITING

Concord Repatriation General Hospital, Concord

NSW 2065

RECRUITING

Genesiscare North Shore, St Leonards

NSW 2145

RECRUITING

Westmead Hospital, Westmead

QLD 4575

RECRUITING

Sunshine Coast Hospital and Health Service, Birtinya

VIC 3128

RECRUITING

Box Hill Hospital, Box Hill

VIC 3168

NOT_YET_RECRUITING

Monash Health, Clayton

WA 6168

RECRUITING

Rockingham Hospital, Cooloongup

WA 6009

RECRUITING

Linear Clinical Research, Nedlands

RECRUITING

One Clinical Research, Nedlands

WA 6005

RECRUITING

Perth Blood Institute, West Perth

14.784-400

RECRUITING

Fundacao Pio Xii Hospital de Amor de Barretos, Barretos

30110-068

RECRUITING

Hospital Felicio Rocho, Belo Horizonte

13083-878

RECRUITING

Universidade de Campinas Centro de Hematologia E Hemoterapia, Campinas

81520-060

RECRUITING

Hospital Erasto Gaertner, Curitiba

89201-260

RECRUITING

Instituto Joinvilense de Hematologia E Oncologia, Joinville

95070-560

RECRUITING

Fundacao Universidade de Caxias Do Sul Instituto de Pesquisas Em Saude, Petrópolis

900350-903

RECRUITING

Hospital de Clinicas de Porto Alegre, Porto AlegreRS

50040-000

RECRUITING

Hospital Do Cancer de Pernambuco, Recife

05402-000

RECRUITING

Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular, São Paulo

29043-260

RECRUITING

Hospital Santa Rita de Cassia Afecc, Vitória

09116

NOT_YET_RECRUITING

Klinikum Chemnitz Ggmbh, Chemnitz

06120

NOT_YET_RECRUITING

Universitatsklinikum Halle, Halle

464-8681

RECRUITING

Aichi Cancer Center Hospital Clinical Oncology, Nagoya

441-8570

RECRUITING

Toyohashi Municipal Hospital, Toyohashishi

260-8717

RECRUITING

Chiba Cancer Center, Chiba

790 8524

RECRUITING

Matsuyama Red Cross Hospital, Matsuyama

503-8502

RECRUITING

Ogaki Municipal Hospital, Ōgaki

RECRUITING

Dokkyo Medical University Saitama Medical Center, Koshigaya

730-8619

RECRUITING

Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima

060-8648

RECRUITING

Hokkaido University Hospital, Sapporo

650-0047

RECRUITING

Kobe City Medical Center General Hospital, KobeShi

890-8520

RECRUITING

Kagoshima University Hospital, Kagoshima

241-8515

RECRUITING

Kanagawa Cancer Center, Yokohama

980-8574

NOT_YET_RECRUITING

Tohoku University Hospital, Sendai

710-8602

RECRUITING

Kurashiki Central Hospital, Kurashikishi

543-8555

RECRUITING

Osaka Red Cross Hospital, Osakashi

701-1192

RECRUITING

National Hospital Organization Okayama Medical Center, Okayama

545-8586

RECRUITING

Osaka Metropolitan University Hospital, Osaka

113-8519

RECRUITING

Institute of Science Tokyo Hospital, Tokyo

221-0855

RECRUITING

Yokohama Municipal Citizens Hospital, Yokohama

0622

RECRUITING

North Shore Hospital, Auckland

30-727

RECRUITING

Pratia McM Krakow, Krakow

93-513

RECRUITING

Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi, Lodz

20-090

RECRUITING

Uniwersytecki Szpital Kliniczny Nr W Lublinie, Lublin

60-185

RECRUITING

Aidport Sp Z O O, Skorzewo

53-439

NOT_YET_RECRUITING

Dolnoslaskie Centrum Onkologii, Pulmonologii I Hematologii, Wroclaw

00917

RECRUITING

Auxilio Mutuo Cancer Center, San Juan

06351

RECRUITING

Samsung Medical Center, GangnamGu

06591

RECRUITING

The Catholic University of Korea, Seoul St Marys Hospital, SeochoGu

03722

RECRUITING

Severance Hospital Yonsei University Health System, SeodaemunGu

03080

RECRUITING

Seoul National University Hospital, Seoul

05505

RECRUITING

Asan Medical Center, SongpaGu

07345

RECRUITING

The Catholic University of Korea, Yeouido St Marys Hospital, Yeongdeungpo-gu

08907

RECRUITING

Ico H Duran I Reynals, Barcelona

06170

NOT_YET_RECRUITING

Etlik City Hospital, Ankara

07025

RECRUITING

Antalya Memorial Hospital, Dokuma

B9 5SS

NOT_YET_RECRUITING

Birmingham Heartlands Hospital, Birmingham

BH7 7DW

RECRUITING

The Royal Bournemouth and Christchurch Hospitals Nhs Foundation, Bournemouth

G12 0YN

RECRUITING

Beatson West of Scotland Cancer Centre, Glasgow

OX3 7LE

RECRUITING

Churchill Hospital Oxford University Hospital Nhs Trust, Headington

NW1 2PG

RECRUITING

University College Hospital, London

CH63 4JY

NOT_YET_RECRUITING

Clatterbridge Cancer Centre, Metropolitan Borough of Wirral

PL6 8DH

RECRUITING

Derriford Hospital, Plymouth

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY

NCT06742996 - A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma | Biotech Hunter | Biotech Hunter