ChemoRT With and Without Dental Stent for Taste Protection in NPC Patients

PHASE2RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

September 24, 2024

Primary Completion Date

December 31, 2025

Study Completion Date

May 31, 2026

Conditions
Nasopharyngeal Carcinoma
Interventions
DEVICE

Dental stent

Dental stent is personalised device for tongue depressing and immobilisation during RT. The aims are to reduce unnecessary RT doses to adjacent non-target healthy tissue, including the tongue, adjacent oral mucosa, parotid glands/ submandibular glands, and temporomandibular joints. Dentists will take impression of the teeth on moulds, and measure the height to raise the bite, the stent is then fabricated as methyl methacrylate resin in the dental laboratory. The resin base extends to the tongue and a flat plate depresses the tongue. This device will be placed before each RT fraction.

OTHER

No dental stent

No dental stent used during chemoradiation treatment

Trial Locations (2)

117599

NOT_YET_RECRUITING

Singapore Institute of Food and Biotechnology Innovation, Singapore

119074

RECRUITING

National University Hospital, Singapore

All Listed Sponsors
collaborator

Singapore Institute of Food and Biotechnology Innovation

OTHER_GOV

lead

National University Hospital, Singapore

OTHER