Testing the Addition of AZD6738 (Ceralasertib) to Immunotherapy to Increase Time Without Cancer for Patients With Non-Small Cell Lung Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

630

Participants

Timeline

Start Date

August 7, 2025

Primary Completion Date

June 30, 2028

Study Completion Date

June 30, 2028

Conditions
Lung Non-Small Cell CarcinomaStage II Lung Cancer AJCC v8Stage IIIA Lung Cancer AJCC v8Stage IIIB Lung Cancer AJCC v8
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood sample collection

DRUG

Ceralasertib

Given PO

PROCEDURE

Computed Tomography

Undergo CT scan

BIOLOGICAL

Durvalumab

Given IV

PROCEDURE

Echocardiography Test

Undergo echocardiography

Trial Locations (116)

10461

RECRUITING

Montefiore Medical Center-Einstein Campus, The Bronx

12801

RECRUITING

Glens Falls Hospital, Glens Falls

15146

RECRUITING

UPMC Hillman Cancer Center - Monroeville, Monroeville

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

15243

RECRUITING

UPMC-Saint Clair Hospital Cancer Center, Pittsburgh

15601

RECRUITING

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

16505

RECRUITING

UPMC Hillman Cancer Center Erie, Erie

17050

RECRUITING

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

17109

RECRUITING

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

18017

RECRUITING

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

RECRUITING

Lehigh Valley Hospital-Cedar Crest, Allentown

18201

RECRUITING

Lehigh Valley Hospital-Hazleton, Hazleton

18301

RECRUITING

Pocono Medical Center, East Stroudsburg

19010

RECRUITING

Bryn Mawr Hospital, Bryn Mawr

19063

RECRUITING

Riddle Memorial Hospital, Media

19096

RECRUITING

Lankenau Medical Center, Wynnewood

19104

RECRUITING

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19301

RECRUITING

Paoli Memorial Hospital, Paoli

19611

RECRUITING

Reading Hospital, West Reading

19713

RECRUITING

Helen F Graham Cancer Center, Newark

RECRUITING

Medical Oncology Hematology Consultants PA, Newark

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

38017

RECRUITING

Baptist Memorial Hospital and Cancer Center-Collierville, Collierville

38120

RECRUITING

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

38652

RECRUITING

Baptist Memorial Hospital and Cancer Center-Union County, New Albany

38655

RECRUITING

Baptist Memorial Hospital and Cancer Center-Oxford, Oxford

38671

RECRUITING

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven

38901

RECRUITING

Baptist Cancer Center-Grenada, Grenada

39705

RECRUITING

Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus

44710

RECRUITING

Aultman Health Foundation, Canton

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

48118

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48341

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

SUSPENDED

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

RECRUITING

Hurley Medical Center, Flint

48912

RECRUITING

University of Michigan Health - Sparrow Lansing, Lansing

53066

RECRUITING

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53149

RECRUITING

ProHealth D N Greenwald Center, Mukwonago

53188

RECRUITING

UW Cancer Center at ProHealth Care, Waukesha

54401

RECRUITING

Aspirus Regional Cancer Center, Wausau

54409

RECRUITING

Langlade Hospital and Cancer Center, Antigo

54451

RECRUITING

Aspirus Medford Hospital, Medford

54481

RECRUITING

Aspirus Cancer Care - Stevens Point, Stevens Point

54494

RECRUITING

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54501

RECRUITING

Aspirus Cancer Care - James Beck Cancer Center, Rhinelander

54601

RECRUITING

Gundersen Lutheran Medical Center, La Crosse

54911

RECRUITING

ThedaCare Regional Cancer Center, Appleton

55102

RECRUITING

United Hospital, Saint Paul

55407

RECRUITING

Abbott-Northwestern Hospital, Minneapolis

55416

RECRUITING

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

RECRUITING

Mercy Hospital, Coon Rapids

59101

RECRUITING

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

59804

RECRUITING

Community Medical Center, Missoula

60026

RECRUITING

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

RECRUITING

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

RECRUITING

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

RECRUITING

Northwestern Medicine Cancer Center Delnor, Geneva

60462

RECRUITING

Northwestern Medicine Orland Park, Orland Park

60523

RECRUITING

Northwestern Medicine Oak Brook, Oak Brook

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

RECRUITING

Northwestern University, Chicago

61021

RECRUITING

Illinois CancerCare-Dixon, Dixon

61350

RECRUITING

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

RECRUITING

Illinois CancerCare-Peru, Peru

61356

RECRUITING

Illinois CancerCare-Princeton, Princeton

61401

RECRUITING

Illinois CancerCare-Galesburg, Galesburg

61443

RECRUITING

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

RECRUITING

Illinois CancerCare-Macomb, Macomb

61520

RECRUITING

Illinois CancerCare-Canton, Canton

61530

RECRUITING

Illinois CancerCare-Eureka, Eureka

61554

RECRUITING

Illinois CancerCare-Pekin, Pekin

61571

RECRUITING

Illinois CancerCare - Washington, Washington

61615

RECRUITING

Illinois CancerCare-Peoria, Peoria

61704

RECRUITING

Illinois CancerCare-Bloomington, Bloomington

62321

RECRUITING

Illinois CancerCare-Carthage, Carthage

62401

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

63128

RECRUITING

Mercy Hospital South, St Louis

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

67042

RECRUITING

Cancer Center of Kansas - El Dorado, El Dorado

67114

RECRUITING

Cancer Center of Kansas - Newton, Newton

67152

RECRUITING

Cancer Center of Kansas - Wellington, Wellington

67156

RECRUITING

Cancer Center of Kansas - Winfield, Winfield

67208

RECRUITING

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

RECRUITING

Ascension Via Christi Hospitals Wichita, Wichita

RECRUITING

Cancer Center of Kansas - Wichita, Wichita

72401

RECRUITING

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

83814

RECRUITING

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

RECRUITING

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

RECRUITING

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

90505

RECRUITING

Torrance Memorial Physician Network - Cancer Care, Torrance

97045

RECRUITING

Providence Willamette Falls Medical Center, Oregon City

97132

RECRUITING

Providence Newberg Medical Center, Newberg

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

06102

RECRUITING

Hartford Hospital, Hartford

06451

RECRUITING

Midstate Medical Center, Meriden

06050

RECRUITING

The Hospital of Central Connecticut, New Britain

01805

RECRUITING

Lahey Hospital and Medical Center, Burlington

01960

RECRUITING

Lahey Medical Center-Peabody, Peabody

01199

RECRUITING

Baystate Medical Center, Springfield

03301

RECRUITING

New Hampshire Oncology Hematology PA-Concord, Concord

03103

RECRUITING

Solinsky Center for Cancer Care, Manchester

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH