Low-dose Radiotherapy Combined with Concurrent Chemotherapy, Toripalimab and Tifcemalimab in the Treatment of ES-SCLC

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

January 10, 2025

Primary Completion Date

February 28, 2026

Study Completion Date

February 29, 2028

Conditions
Extensive-stage Small-cell Lung Cancer
Interventions
RADIATION

Low-dose radiotherapy

The LDRT deals with primary tumour in a 15 Gy of 5 fractions over five days, starting from Day 1 in the first cycle.

DRUG

Tifcemalimab injection

100 mg or 200 mg q3w until disease progression or intolerable toxicity;

DRUG

Toripalimab

240 mg q3w until disease progression or intolerable toxicity;

DRUG

Cisplatin

75 mg/m2 q3w for 4-6 cycles;

DRUG

Carboplatin

AUC = 5, q3w for 4-6 cycles;

DRUG

Etoposide

100 mg/m2, d1, d2, d3, q3w for 4-6 cycles;

All Listed Sponsors
lead

Sichuan University

OTHER