NCT06731907 - A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01) | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

March 30, 2025

Primary Completion Date

March 12, 2032

Study Completion Date

March 12, 2032

Conditions

Non-small Cell Lung Cancer

Interventions

BIOLOGICAL

Pembrolizumab

Pembrolizumab 200mg IV Infusion.

DRUG

Carboplatin

Carboplatin IV infusion AUC5 or 6 mg/mL•min and not exceeding 900mg.

DRUG

Paclitaxel

Paclitaxel 200 mg/m\^2 IV infusion.

DRUG

Nab-paclitaxel

Nab-paclitaxel 100mg/m\^2 IV infusion.

DRUG

Pemetrexed

Pemetrexed 500mg/m\^2 IV infusion.

BIOLOGICAL

HER3-DXd

HER3-Dxd 5.6mg/kg IV infusion.

Trial Locations (33)

1121

RECRUITING

Országos Korányi Pulmonológiai Intézet ( Site 0060), Budapest

5000

RECRUITING

Jasz-Nagykun-Szolnok Megyei Hetenyi Gyula Korhaz-Rendelointezet ( Site 0061), Szolnok

9024

RECRUITING

Petz Aladar Egyetemi Oktato Korhaz ( Site 0062), Győr

18009

RECRUITING

CNE CC of Oncology Hematol ( Site 0130), Cherkasy

19104

RECRUITING

Abramson Cancer Center ( Site 0010), Philadelphia

20132

RECRUITING

IRCCS Ospedale San Raffaele ( Site 0171), Milan

21029

RECRUITING

"Communal Noncommercial Enterprise Podillia Regional Oncology Center Of Vinnytsia Regional Council ( Site 0133)", Vinnytsia

21237

RECRUITING

MedStar Franklin Square Medical Center ( Site 0033), Baltimore

28223

RECRUITING

Hospital Universitario Quiron Madrid ( Site 0091), Madrid

40536

RECRUITING

University of Kentucky ( Site 0019), Lexington

57104

RECRUITING

Sanford Cancer Center ( Site 0038), Sioux Falls

58013

RECRUITING

"Municipal Enterprise Bukovinian сlinical oncology сenter ( Site 0136)", Chernivtsi

58102

RECRUITING

Sanford Fargo Medical Center ( Site 0039), Fargo

76018

RECRUITING

CNCE Precarpathian Clinical Oncologic Center ( Site 0131), Ivano-Frankivsk

3109601

RECRUITING

Rambam Health Care Campus ( Site 0076), Haifa

4941492

RECRUITING

Rabin Medical Center ( Site 0074), Petah Tikva

6423906

RECRUITING

Sourasky Medical Center ( Site 0077), Tel Aviv

7500653

RECRUITING

Centro de Estudios Clínicos SAGA ( Site 0162), Santiago

7500921

RECRUITING

FALP ( Site 0161), Santiago

8420383

RECRUITING

Bradfordhill ( Site 0160), Santiago

115 27

RECRUITING

"THORACIC GENERAL HOSPITAL OF ATHENS I SOTIRIA-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 0204)", Athens

570 01

RECRUITING

European Interbalkan Medical Center-Oncology Department ( Site 0205), Thessaloniki

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 0174), Roma

60-569

RECRUITING

Wielkopolskie Centrum Pulmonologii i Torakochirurgii-Oddzial Onkologii Klinicznej z Pododdzialem Dz ( Site 0153), Poznan

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 0151), Warsaw

80-214

RECRUITING

Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit ( Site 0150), Gdansk

75-581

RECRUITING

Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 0152), Koszalin

08908

RECRUITING

Institut Català d'Oncologia - L'Hospitalet ( Site 0090), L'Hospitalet de Llobregat

08008

RECRUITING

HOSPITAL CLÍNIC DE BARCELONA ( Site 0092), Barcelona

01250

RECRUITING

Baskent University Dr. Turgut Noyan Research and Training Center ( Site 0141), Adana

06410

RECRUITING

Hacettepe Universite Hastaneleri ( Site 0140), Ankara

03022

RECRUITING

VISION PARTNER Medical Centre ( Site 0134), Kyiv

03126

RECRUITING

Shalimov Institute of Surgery and Transplantation ( Site 0135), Kyiv