726
Participants
Start Date
February 27, 2025
Primary Completion Date
June 1, 2028
Study Completion Date
February 1, 2030
Trastuzumab Deruxtecan
T-DXd will be administered at a dose of 5.4 mg/kg intravenously (IV) every 3 weeks (Q3W)
pembrolizumab
Pembrolizumab will be administered at a dose of 200 mg IV Q3W
Trastuzumab
Trastuzumab will be administered at a loading dose of 8 mg/kg IV followed by 6 mg/kg IV Q3W
Chemotherapy
"For Arms M1 and E1: 5-FU or capecitabine will be administered.~For Arms M2 and E2: Cisplatin plus 5-FU or oxaliplatin plus capecitabine will administered."
RECRUITING
Chang Gung Memorial Hospital,Linkou, Taoyuan
RECRUITING
Korea University Anam Hospital, Seoul
RECRUITING
Seoul National University Hospital, Seoul
RECRUITING
Severance Hospital, Yonsei University Health System, Seoul
RECRUITING
Asan Medical Center, Seoul
RECRUITING
Samsung Medical Center, Seoul
NOT_YET_RECRUITING
Memorial Sloan Kettering Cancer Center - MAIN, New York
NOT_YET_RECRUITING
Montefiore Medical Center, The Bronx
RECRUITING
Seoul National University Bundang Hospital, Seongnam
NOT_YET_RECRUITING
Penn State University Milton S. Hershey Medical Center, Hershey
NOT_YET_RECRUITING
Maryland Oncology Hematology, P.A., Silver Spring
RECRUITING
Gachon University Gil Medical Center, Incheon
NOT_YET_RECRUITING
Blue Ridge Cancer Care, Roanoke
NOT_YET_RECRUITING
Prisma Health Cancer Institute, ITOR, CRU, Greenville
NOT_YET_RECRUITING
Tennessee Oncology Nashville Midtown, Nashville
NOT_YET_RECRUITING
University of Michigan Comprehensive Cancer Center Michigan Medicine, Ann Arbor
RECRUITING
Jeonbuk national university hospital, Jeonju
WITHDRAWN
Minnesota Oncology Hematology, P.A., Minneapolis
RECRUITING
Chonnam National University Hwasun Hospital, Hwasun-gun
RECRUITING
Orchard Healthcare Research Inc., Skokie
NOT_YET_RECRUITING
University of Kansas Medical Center Research Institute, Inc., Kansas City
NOT_YET_RECRUITING
UT Southwestern Medical Center, Dallas
NOT_YET_RECRUITING
Texas Oncology, P.A. - Tyler, Tyler
NOT_YET_RECRUITING
Providence Portland Medical Center, Portland
WITHDRAWN
Wenatchee Valley Hospital & Clinics, Wenatchee
RECRUITING
Beijing Cancer Hospital, Beijing
RECRUITING
Peking University Third Hospital, Beijing
RECRUITING
Taipei Veterans General Hospital, Taipei
RECRUITING
Hubei Cancer Hospital, Wuhan
NOT_YET_RECRUITING
Yale Cancer Center, New Haven
NOT_YET_RECRUITING
Tufts Medical Center, Boston
NOT_YET_RECRUITING
Virginia Oncology Associates, Norfolk
NOT_YET_RECRUITING
CEMIC Ciudad Autonoma, Buenos Aires
NOT_YET_RECRUITING
Instituto Medico Especializado Alexander Fleming, Buenos Aires
NOT_YET_RECRUITING
Clinica Universitaria Privada Reina Fabiola, Córdoba
NOT_YET_RECRUITING
Centro de Investigaciones Medicas Mar del Plata, Mar del Plata
NOT_YET_RECRUITING
Instituto Medico de la Fundacion Estudios Clinicos, Rosario
NOT_YET_RECRUITING
Flinders Medical Centre, Bedford Park
RECRUITING
Monash Medical Centre Clayton, Clayton
NOT_YET_RECRUITING
Townsville University Hospital, Douglas
RECRUITING
Peter MacCallum Cancer Centre, North Melbourne
RECRUITING
GenesisCare North Shore (Oncology), St Leonards
RECRUITING
St John of God Subiaco Hospital, Subiaco
NOT_YET_RECRUITING
Wollongong Hospital, Wollongong
NOT_YET_RECRUITING
LKH - Universitaetsklinikum Graz, Graz
NOT_YET_RECRUITING
Medizinische Universität Innsbruck, Innsbruck
NOT_YET_RECRUITING
Medizinische Universität Wien, Vienna
NOT_YET_RECRUITING
St. Josef Krankenhaus Wien, Vienna
NOT_YET_RECRUITING
Landesklinikum Wiener Neustadt, Wiener Neustadt
RECRUITING
Institut Jules Bordet, Anderlecht
RECRUITING
AZ Sint-Lucas, Bruges
RECRUITING
Cliniques Universitaires Saint-Luc, Brussels
NOT_YET_RECRUITING
UZ Leuven, Leuven
NOT_YET_RECRUITING
Centre Hospitalier Universitaire de Liege, Liège
RECRUITING
CHU UCL Namur, Namur
NOT_YET_RECRUITING
Centro de Oncologia - Unidade Brasilia - Hospital Sirio Libanes, Brasília
NOT_YET_RECRUITING
ICESP - Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira Sao Paulo, Brazil
NOT_YET_RECRUITING
CEPON - Centro de Pesquisas Oncológicas de Santa Catarina, Florianópolis
NOT_YET_RECRUITING
Fundação Doutor Amaral Carvalho, Jaú
NOT_YET_RECRUITING
Liga Norte-Rio-Grandense Contra o Câncer, Natal
NOT_YET_RECRUITING
Hospital de Clínicas de Porto Alegre, Porto Alegre
NOT_YET_RECRUITING
Hospital São Lucas da PUCRS, Porto Alegre
NOT_YET_RECRUITING
IMIP - Instituto de Medicina Integral Professor Fernando Figueira, Recife
NOT_YET_RECRUITING
Hospital das Clínicas FMRP-USP, Ribeirão Preto
NOT_YET_RECRUITING
INCA - Instituto Nacional de Câncer, Rio de Janeiro
NOT_YET_RECRUITING
Obras Sociais Irmã Dulce - Hospital Santo Antônio, Salvador
NOT_YET_RECRUITING
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto, Sao Jose Rio Preto
NOT_YET_RECRUITING
CHUS - Hôtel-Dieu, Sherbrooke
NOT_YET_RECRUITING
Sunnybrook Health Sciences Centre, Toronto
NOT_YET_RECRUITING
University Health Network - Princess Margaret Cancer Centre, Toronto
NOT_YET_RECRUITING
Biocenter, Concepción
NOT_YET_RECRUITING
URUMED Spa, Rancagua
NOT_YET_RECRUITING
Centro de Investigacion del Maule, Region Del Maule
NOT_YET_RECRUITING
Centro de Estudios Clinicos SAGA, Santiago
RECRUITING
FALP - Fundación Arturo López Pérez, Santiago
NOT_YET_RECRUITING
Hospital Clinico Universidad de Chile, Santiago
RECRUITING
Fujian Cancer Hospital, Fuzhou
RECRUITING
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou
RECRUITING
The First Affiliated Hospital of Zhejiang University school of medicine, Hangzhou
RECRUITING
Harbin Medical University Cancer Hospital, Harbin
RECRUITING
Anhui Provincial Cancer Hospital, Hefei
RECRUITING
Shandong Cancer Hospital, Jinan
RECRUITING
Gansu Provincial Cancer Hospital, Lanzhou
NOT_YET_RECRUITING
Lanzhou University Second Hospital, Lanzhou
RECRUITING
Linyi Cancer Hospital, Linyi
RECRUITING
Meizhou People's Hospital, Meizhou
NOT_YET_RECRUITING
Liaoning Cancer Hospital & Institute, Shenyang
RECRUITING
The Second Affiliated Hospital of Soochow University, Suzhou
NOT_YET_RECRUITING
Shanxi Provincial Cancer Hospital, Taiyuan
NOT_YET_RECRUITING
Shanxi Provincial People's Hospital, Taiyuan
RECRUITING
Tianjin Medical University Cancer Institute & Hospital, Tianjin
NOT_YET_RECRUITING
The Affiliated Cancer Hospital of Xinjiang Medical university, Ürümqi
RECRUITING
Wuxi 4th People's Hospital, Wuxi
RECRUITING
The First Affiliated Hospital of Xian Jiaotong University, Xi'an
NOT_YET_RECRUITING
The First Affiliated Hospital of Xiamen University, Xiamen
NOT_YET_RECRUITING
Fudan University Shanghai Cancer Center, Xuhui District
RECRUITING
Xuzhou Central Hospital, Xuzhou
RECRUITING
General Hospital of Ningxia Medical University, Yinchuan
NOT_YET_RECRUITING
Masarykuv onkologicky ustav, Brno
NOT_YET_RECRUITING
Fakultni nemocnice Hradec Kralove, Hradec Králové
NOT_YET_RECRUITING
Fakultni nemocnice Olomouc, Olomouc
NOT_YET_RECRUITING
Fakultni nemocnice v Motole, Prague
RECRUITING
Institut Sainte Catherine, Avignon
RECRUITING
CHU de Brest - Hopital de la Cavale Blanche, Brest
NOT_YET_RECRUITING
Centre Georges François Leclerc, Dijon
RECRUITING
CHU Grenoble - Hopital Michallon, Grenoble
RECRUITING
Centre Oscar Lambret, Lille
NOT_YET_RECRUITING
Hopital Prive Jean Mermoz, Lyon
RECRUITING
CHU Montpellier, Saint Eloi, Montpellier
NOT_YET_RECRUITING
Chru De Nantes Hotel-Dieu, Nantes
RECRUITING
Hôpital Européen Georges Pompidou, Paris
RECRUITING
Hôpital Saint-Antoine, Paris
RECRUITING
Institut Mutualiste Montsouris, Paris
RECRUITING
CHU Bordeaux - Hôpital Haut-Lévêque, Pessac
RECRUITING
CHU Poitiers - Hôpital la Milétrie, Poitiers
RECRUITING
Institut de Cancérologie de Strasbourg Europe - ICANS, Strasbourg
RECRUITING
Hôpital Foch, Suresnes
RECRUITING
Hopital Rangueil, Toulouse
NOT_YET_RECRUITING
Charité Universitätsmedizin Berlin - Campus Virchow-Klinikum, Berlin
NOT_YET_RECRUITING
Vivantes Klinikum im Friedrichshain, Berlin
NOT_YET_RECRUITING
Klinikum Chemnitz gGmbH, Chemnitz
NOT_YET_RECRUITING
Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden
NOT_YET_RECRUITING
Universitaetsklinikum Frankfurt Goethe-Universitaet, Frankfurt am Main
NOT_YET_RECRUITING
Universitaetsklinikum Hamburg-Eppendorf, Hamburg
NOT_YET_RECRUITING
Universitaetsklinikum Heidelberg, Heidelberg
NOT_YET_RECRUITING
Universitaetsklinikum Leipzig AoeR, Leipzig
NOT_YET_RECRUITING
Klinikum rechts der Isar der TU Muenchen, München
NOT_YET_RECRUITING
Presidio Ospedaliero Garibaldi Nesima, Catania
NOT_YET_RECRUITING
Azienda Ospedaliera Universitaria Careggi, Florenze
NOT_YET_RECRUITING
IRCCS Ospedale Policlinico San Martino, Genova
NOT_YET_RECRUITING
Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda), Milan
NOT_YET_RECRUITING
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
NOT_YET_RECRUITING
Ospedale San Raffaele, Milan
NOT_YET_RECRUITING
A.O.U. Policlinico di Modena, Modena
NOT_YET_RECRUITING
"Azienda Ospedaliera Universitaria- Università degli Studi della Campania Luigi Vanvitelli", Napoli
NOT_YET_RECRUITING
IOV - Istituto Oncologico Veneto IRCCS, Padua
NOT_YET_RECRUITING
Azienda Ospedaliero Universitaria Pisana, Pisa
NOT_YET_RECRUITING
Azienda Unità Sanitaria Locale- Ravenna, Ravenna
NOT_YET_RECRUITING
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome
NOT_YET_RECRUITING
Istituto Clinico Humanitas, Rozzano
NOT_YET_RECRUITING
IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo
NOT_YET_RECRUITING
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino
NOT_YET_RECRUITING
Azienda Ospedaliera Card. G. Panico, Tricase
RECRUITING
Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, Bunkyō City
RECRUITING
National Cancer Center Hospital, Chūōku
RECRUITING
Gifu University Hospital, Gifu
RECRUITING
Hiroshima City Hiroshima Citizens Hospital, Hiroshima
RECRUITING
National Cancer Center Hospital East, Kashiwa-shi
RECRUITING
Kochi Health Sciences Center, Kochi
RECRUITING
Aichi Cancer Center Hospital, Nagoya
RECRUITING
Miyagi Cancer Center, Natori-shi
NOT_YET_RECRUITING
Antoni van Leeuwenhoek, Amsterdam
NOT_YET_RECRUITING
Medisch Centrum Leeuwarden, Leeuwarden
RECRUITING
Radboudumc, Nijmegen
NOT_YET_RECRUITING
Erasmus Medisch Centrum, Rotterdam
NOT_YET_RECRUITING
ETZ Elisabeth, Tilburg
NOT_YET_RECRUITING
UMC Utrecht, Utrecht
NOT_YET_RECRUITING
Haukeland University Hospital, Bergen
NOT_YET_RECRUITING
Akershus universitetssykehus HF, Lørenskog
NOT_YET_RECRUITING
Oslo Universitetssykehus HF, Ullevål, Oslo
NOT_YET_RECRUITING
St. Olavs Hospital Hf, Universitetssykehuset i Trondheim, Trondheim
NOT_YET_RECRUITING
Beskidzkie Centrum Onkologii im.Jana Pawla II, Bielsko-Biala
NOT_YET_RECRUITING
Szpital Wojewodzki im. Mikolaja Kopernika, Koszalin
NOT_YET_RECRUITING
Wielkopolskie Centrum Onkologii, Poznan
NOT_YET_RECRUITING
Narodowy Instytut Onkologii im. Marii Sklodowskiej Curie Panstwowy Instytut Badawczy W Warszawie, Warsaw
NOT_YET_RECRUITING
Warszawski Uniwersytet Medyczny, Warsaw
NOT_YET_RECRUITING
Hospital de Braga, Braga
NOT_YET_RECRUITING
Hospital da Senhora da Oliveira Guimarães, E.P.E., Guimarães
NOT_YET_RECRUITING
Fundação Champalimaud, Lisbon
NOT_YET_RECRUITING
Hospital da Luz, Lisbon
NOT_YET_RECRUITING
Unidade Local de Saúde de Santa Maria, E.P.E. - Hospital de Santa Maria, Lisbon
NOT_YET_RECRUITING
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto
NOT_YET_RECRUITING
Institutul Clinic Fundeni, Bucharest
NOT_YET_RECRUITING
"Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj Napoca", Cluj-Napoca
NOT_YET_RECRUITING
S.C Medisprof S.R.L, Cluj-Napoca
NOT_YET_RECRUITING
Centrul de Oncologie Sfantul Nectarie Craiova, Craiova
NOT_YET_RECRUITING
Institutul Regional de Oncologie Iasi, Iași
NOT_YET_RECRUITING
S.C Ovidius Clinical Hospital S.R.L, Ovidiu
NOT_YET_RECRUITING
S.C. Sigmedical Services SRL, Suceava
RECRUITING
Chungbuk National University Hospital, Cheongju-si
RECRUITING
Kyungpook National University Chilgok Hospital, Daegu
RECRUITING
National Cancer Center, Goyang-si
RECRUITING
CHA Bundang Medical Center, CHA University, Seongnam-si
RECRUITING
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul
NOT_YET_RECRUITING
ICO Badalona - Hospital Universitari Germans Trias i Pujol, Badalona
NOT_YET_RECRUITING
Hospital Clinic de Barcelona, Barcelona
NOT_YET_RECRUITING
Hospital del Mar, Barcelona
NOT_YET_RECRUITING
Hospital Universitari Vall d'Hebron, Barcelona
NOT_YET_RECRUITING
Hospital Universitario Reina Sofia, Córdoba
NOT_YET_RECRUITING
Hospital General Universitario de Elche, Elche
NOT_YET_RECRUITING
ICO l'Hospitalet - Hospital Duran i Reynals, L'Hospitalet de Llobregat
NOT_YET_RECRUITING
Hospital General Universitario Gregorio Marañon, Madrid
NOT_YET_RECRUITING
Hospital Universitario La Paz, Madrid
NOT_YET_RECRUITING
Hospital Universitario Ramon y Cajal, Madrid
NOT_YET_RECRUITING
MD Anderson Cancer Centre, Madrid
NOT_YET_RECRUITING
Hospital Regional Universitario de Malaga, Málaga
NOT_YET_RECRUITING
Hospital General Universitario Morales Meseguer, Murcia
NOT_YET_RECRUITING
Hospital Universitario Central de Asturias, Oviedo
NOT_YET_RECRUITING
Hospital Universitario de Navarra, Pamplona
NOT_YET_RECRUITING
Hospital Universitario Virgen del Rocio, Seville
NOT_YET_RECRUITING
Hospital Clinico Universitario de Valencia, Valencia
RECRUITING
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City
RECRUITING
National Cheng Kung University Hospital, Tainan City
RECRUITING
National Taiwan University Hospital, Taipei
RECRUITING
Siriraj Hospital, Bangkoknoi
NOT_YET_RECRUITING
Vajira Hospital, Dusit
RECRUITING
Songklanagarind Hospital, Hat Yai
NOT_YET_RECRUITING
Chulabhorn Hospital, Laksi
NOT_YET_RECRUITING
King Chulalongkorn Memorial Hospital, Pathum Wan
NOT_YET_RECRUITING
Medical Park Seyhan Hospital, Adana
NOT_YET_RECRUITING
Ankara City Hospital, Ankara
NOT_YET_RECRUITING
Dr. Abdurrahman Yurtaslan Oncology Teaching and Research Hospital, Ankara
NOT_YET_RECRUITING
Hacettepe University Medical Faculty, Ankara
NOT_YET_RECRUITING
Dicle University, Medical faculty, Diyarbakır
NOT_YET_RECRUITING
Ataturk University Medical Faculty, Erzurum
NOT_YET_RECRUITING
Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul
NOT_YET_RECRUITING
Medipol University Medical Faculty, Istanbul
NOT_YET_RECRUITING
İ.E.Ü. Medicalpoint İzmir Hastanesi, Izmir
NOT_YET_RECRUITING
Medical Park Samsun Hastanesi, Samsun
NOT_YET_RECRUITING
Queen Elizabeth Hospital, Birmingham
NOT_YET_RECRUITING
Velindre Cancer Centre, Cardiff
NOT_YET_RECRUITING
Ninewells Hospital, Dundee
NOT_YET_RECRUITING
Castle Hill Hospital, Hull
NOT_YET_RECRUITING
St James's University Hospital, Leeds
NOT_YET_RECRUITING
Sarah Cannon Research Institute UK, London
NOT_YET_RECRUITING
University College London Hospitals, London
NOT_YET_RECRUITING
Altnagelvin Area Hospital, Londonderry
NOT_YET_RECRUITING
The Christie Hospital, Manchester
NOT_YET_RECRUITING
Royal Marsden Hospital, Sutton
NOT_YET_RECRUITING
Hanoi Oncology hospital, Hanoi
NOT_YET_RECRUITING
National Cancer Hospital, Hanoi
NOT_YET_RECRUITING
Cho Ray Hospital, Ho Chi Minh City
NOT_YET_RECRUITING
HCMC Oncology Hospital, Ho Chi Minh City
NOT_YET_RECRUITING
HCMC University Medical Center, HoChiMinh
NOT_YET_RECRUITING
Cité de la Santé de Laval, Laval
WITHDRAWN
Mount Sinai Hospital, Toronto
RECRUITING
JCHO Kyushu Hospital, Kitakyushu
RECRUITING
Cancer Institute Hospital of JFCR, Kōtoku
RECRUITING
NHO Shikoku Cancer Center, Matsuyama
RECRUITING
Niigata Cancer Center Hospital, Niigata
RECRUITING
Osaka International Cancer Institute, Osaka
RECRUITING
Kindai University Hospital, Osakasayama-shi
RECRUITING
Hokkaido University Hospital, Sapporo
RECRUITING
Osaka University Hospital, Suita-shi
RECRUITING
Kanagawa Cancer Center, Yokohama
Lead Sponsor
Merck Sharp & Dohme LLC
INDUSTRY
Daiichi Sankyo
INDUSTRY