Feasibility of Closed-loop TCI Based on New EEG Baseline in the Presence of Low Dose of Esketamine

Esketamine at low dose was administered(0.2mg· kg-1, 5 ug· kg-1 continuous infusion) and drug dosage was adjusted(propofol and remifentanil) based on the new BIS baseline ( calculated from the pilot study).

Close-loop TCI control was under new BIS baseline(calculated from pilot study) in the presence of esketamine at low dose.

An equivalent dose of saline was given and closed-loop control stared.

Drug dosage was adjused under close-loop control based on original BIS baseline.