A Clinical Research About CD70-targeted CAR-NKT Cells Therapy in Subjects with Advanced Malignant Solid Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

13

Participants

Timeline

Start Date

November 14, 2024

Primary Completion Date

October 17, 2026

Study Completion Date

October 17, 2026

Conditions
Advanced Malignant Solid Tumors
Interventions
BIOLOGICAL

CAR-NKT Cells treatment

"Cyclophosphamide + Fludarabine + Infusion of CAR-NKT Cells Lymphodepleting regimen, Cyclophosphamide 250mg/m2 IV on day -5 to -3 and Fludarabine 25mg/m2 IV on days -5 to -3. Followed by infusion of CAR-NKT on day 0.~Potential CGC738 doses:~Dose level 1: 5.0×106 CAR- NKT cells/m2; Dose level 2: 1.5×107 CAR- NKT cells/m2; Dose level 3: 4.5×107 CAR- NKT cells/m2;"

Trial Locations (1)

Unknown

RECRUITING

Beijing Cancer Hospital, Beijing

All Listed Sponsors
collaborator

Suzhou Cure Genetics Biosciences Co., Limited.

UNKNOWN

lead

Peking University Cancer Hospital & Institute

OTHER