NCT06727773View on ClinicalTrials.gov

Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

May 7, 2025

Primary Completion Date

October 31, 2028

Study Completion Date

October 31, 2028

Conditions
Breast CancerLocally Advanced Breast CancerCognitive ImpairmentCognitive DeclineCognitive ChangeBreast Cancer Stage IBreast Cancer Stage IIBreast Cancer Stage III
Interventions
DRUG

Memantine

memantine capsule

DRUG

Placebo medication

placebo capsule

OTHER

Exercise Intervention

Exercise Intervention participants will concurrently engage in remotely delivered Get Real \& Heel, 3d/week. Intensity for aerobic and strength-training components will progress as tolerated under the direction of a trained exercise physiologist.

OTHER

Exercise Control

Exercise control will have access to a library of pre-recorded Get Real \& Heel sessions.

Trial Locations (1)

27599

RECRUITING

Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, Chapel Hill

All Listed Sponsors
collaborator

National Institute on Aging (NIA)

NIH

lead

UNC Lineberger Comprehensive Cancer Center

OTHER

NCT06727773 - Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer | Biotech Hunter | Biotech Hunter