756
Participants
Start Date
March 21, 2025
Primary Completion Date
June 30, 2027
Study Completion Date
September 30, 2029
eftilagimod alfa
30 mg of efti every 2 weeks subcutaneously for the first 6 months, thereafter every 3 weeks for up to 24 months in total
carboplatin plus paclitaxel
For participants with squamous histology for 4 cycles (1 cycle = 3 weeks) as follows: every 3 weeks: carboplatin area under the curve (AUC) 5 or 6 in combination with paclitaxel 175 mg/m2 or 200 mg/m2
cisplatin or carboplatin + pemetrexed
For participants with nonsquamous histology for 4 cycles (1 cycle = 3 weeks) as follows: every 3 weeks: cisplatin 75 mg/m2 or carboplatin AUC 5 or 6 in combination with pemetrexed 500 mg/m2. After the initial 4 cycles, pemetrexed 500 mg/m2 maintenance therapy will be administered every 3 weeks
pembrolizumab (KEYTRUDA®)
200 mg pembrolizumab (KEYTRUDA®) every 3 weeks i.v. for up to approximately 24 months
Placebo
efti-matching placebo every 2 weeks subcutaneously for the first 6 months, thereafter every 3 weeks for up to 24 months in total
RECRUITING
Lyell McEwin Hospital, Elizabeth Vale
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Greenslopes Private Hospital, Greenslopes
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The Alfred Hospital, Melbourne
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Tasman Oncology Research Ltd, Southport
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St John of God Subiaco Hospital, Subiaco
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Royal Darwin Hospital, Tiwi
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Calvary Mater Newcastle, Waratah
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Cancer Care Wollongong Pty Limited, Wollongong
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Landeskrankenhaus-Universitätsklinikum Graz, KLinische Abteilung für Pulmonologie, Graz
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Vienna General Hospital, Vienna
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Antwerp University Hospital, Antwerp
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Algemeen Ziekenhuis Maria Middelares, Ghent
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Clinique et Maternité Sainte-Elisabeth, Namur
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Multiprofile Hospital for Active Treatment - Dobrich AD, Dobrich
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"Multiprofile Hospital For Active Treatment Dr. Tota Venkova AD", Gabrovo
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MHAT Uni Hospital OOD, Panagyurishte
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Complex Oncology Center Ruse, Rousse
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Multiprofile Hospital for Active Treatment Serdika EOOD, Sofia
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Brampton Civic Hospital, Brampton
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McGill University - Jewish General Hospital (JGH) - Lady Davis Institute for Medical Research, Montreal
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Unite de recherche clinique du CISSS des Laurentides, Saint-Jérôme
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Centro de Oncologia de Precision, Las Condes
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Facultad Odontología Unipac, Santiago
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Klinički Bolnički Centar Osijek, Osijek
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Klinicka Bolnica Centar - Sestre Milosrdnice - Klinika Za Tumore (University Hospital for Tumors), Zagreb
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Klinički Bolnički Centar Sestre Milosrdnice, Zagreb
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Klinički Bolnički Centar Zagreb - Klinika Za Plućne Bolesti Jordanovac, Zagreb
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High-tech Hospital Med Center, Batumi
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High Technology Medical Center, University Clinic, Tbilisi
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Institute of Clinical Oncology, Tbilisi
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Mardaleishvili Medical Centre, Tbilisi
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Evangelische Lungenklinik Berlin, Berlin
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Krankenhaus Nordwest, Frankfurt am Main
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Krankenhaus Martha-Maria Halle-Dölau, Halle
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Gemeinschaftspraxis Dr Klemper, Mainz
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Gemeinschaftspraxis für Hämatologie und Onkologie, Münster
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Robert-Bosch-Krankenhaus, Stuttgart
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"General Hospital of Athens Laiko", Athens
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Sotiria Chest Diseases Hospital, Athens
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University of Thessaly- General University Hospital of Larissa, Larissa
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University of Patras - Rio Regional University Hospital, Pátrai
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Metropolitan Hospital, Department of Oncology, Piraeus
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Bioclinic of Thessaloniki, Thessaloniki
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Interbalkan Medical Center of Thessaloniki, Thessaloniki
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St. Luke's Hospital S.A., Thessaloniki
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HCG Cancer Centre - Double Road (Bangalore Institute of Oncology (BIO)), Bangalore
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Geri Care Hospital T.Nagar, Chennai
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Voluntary Health Services Hospital, Chennai
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Chittaranjan National Cancer Institute, Kolkata
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Maulana Azad Medical College, New Delhi
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Sunact Cancer Institute Pvt. Ltd., Thāne
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Regional Cancer Centre Thiruvananthapuram, Thiruvananthapuram
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Tata Memorial Centre - Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Varanasi
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Beaumont Hospital, Dublin
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Mater Misericordiae University Hospital, Dublin
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Tallaght University Hospital, Dublin
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Azienda Ospedaliera San Giuseppe Moscati, Avellino
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Centro di Riferimento Oncologico (CRO), Aviano
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Istituto per la Ricerca e la Cura del Cancro (IRCC) - Istituto di Candiolo, Candiolo
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Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
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"Istituto Nazionale Tumori (INT) Fondazione G. Pascale di Napoli", Napoli
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Azienda Ospedaliera di Perugia - Ospedale Santa Maria della Misericordia, Perugia
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Azienda Ospedaliera Santa Maria di Terni, Terni
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Latvian Oncology Center, Riga
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Paula Stradiņa Klīniskā Universitātes Slimnīca, Riga
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Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Kaunas
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Nacionalinis Vezio Institutas, Vilnius
RECRUITING
Hospital Tengku Ampuan Afzan, Kuantan
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Hospital Umum Sarawak - Clinical Research Centre, Kuching
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Gleneagles Medical Centre - Penang, Pulau Pinang
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Hospital Pulau Pinang, Pulau Pinang
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Szpital Morski im. PCK (Maritime Hospital) (Gdynskie Centrum Onkologii), Gdynia
RECRUITING
"Przychodnia Lekarska KOMED", Konin
RECRUITING
Instytut Medyczny Santa Familia Sp. z o. o. w Łodzi, Lodz
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IP Clinic Sp. z o.o., Lodz
RECRUITING
Hospital Garcia de Orta, EPE, Almada
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Unidade Local de Saude de Santa Maria, EPE - Hospital Pulido Valente, Lisbon
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Unidade Local de Saude de Loures - Odivelas, E. P. E., Loures
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Centrul Medical Medicover Victoria, Bucharest
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Spitalul Memorial Healthcare International, Bucharest
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Onco Clinic Consult SA, Craiova
RECRUITING
OncoLab, Craiova
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Victoria Hospital - Centrul de Oncologie Euroclinic SRL, Iași
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Ovidius Clinical Hospital S.R.L., Ovidiu
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Hospital Universitari Germans Trias i Pujol, Badalona
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Hospital de la Santa Creu i Sant Pau, Barcelona
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Hospital Universitario Vall d'Hebron, Barcelona
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Instituto Oncologico Dr. Rosell - Hospital Universitari Quiron Dexeus Location, Barcelona
RECRUITING
Hospital Universitario Reina Sofía, Córdoba
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HM Universitario Sanchinarro, Madrid
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Hospital Regional Universitario de Málaga - Hospital General, Málaga
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Hospital Universitario Central de Asturias, Oviedo
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Parc Tauli Hospital Universitari, Sabadell
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Hospital Universitario Virgen Macarena, Seville
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Hospital Clinico Universitario de Valencia, Valencia
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"Hospital Clínico Universitario Lozano Blesa", Zaragoza
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Gulhane Egitim ve Arastirma Hastanesi, Ankara
RECRUITING
Hacettepe Universitesi Kanser Enstitusu (Hacettepe University Cancer Institute), Ankara
RECRUITING
Istanbul Oncology Hospital, Cevizli
RECRUITING
Bahcelievler Memorial Hospital, Istanbul
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T.C. S.B. Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul
RECRUITING
Sakarya Universitesi Tıp Fakultesi Dekanligi, Sakarya
RECRUITING
University Hospitals Birmingham NHS Foundation Trust - New Queen Elizabeth Hospital Birmingham, Birmingham
RECRUITING
The Royal Surrey County Hospital NHS Foundation Trust, Guildford
RECRUITING
The Christie NHS Foundation Trust - Christie Hospital, Manchester
Merck Sharp & Dohme LLC
INDUSTRY
Immutep S.A.S.
INDUSTRY