856
Participants
Start Date
May 1, 2024
Primary Completion Date
May 1, 2027
Study Completion Date
December 31, 2029
Ultrasonic teeth cleaning plus Tinidazole microneedle patches applying
After gargling with compound chlorhexidine rinse or 3% hydrogen peroxide rinse for 1 minute, ultrasonic teeth cleaning was performed. After teeth cleaning, the wound was rinsed with 3% hydrogen peroxide and bleeding was stopped. After ultrasonic teeth cleaning, two metronidazole oral composite microneedle patches were immediately applied to the upper and lower gums near the inner side of the first molar, especially where the teeth were lost or damaged. The mouth was kept closed for 15 minutes. After the microneedles were fully degraded, the patient could leave the clinic.
The Clinical Medical College, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang
Shanghai Zhongshan Hospital
OTHER
The First Affiliated Hospital of Henan University of Science and Technology
OTHER