Clinical Study on the Impact of Eradication of Oral Porphyromonas Gingivalis on the Prognosis of Early Esophageal Cancer After ESD Surgery

NAActive, not recruitingINTERVENTIONAL
Enrollment

856

Participants

Timeline

Start Date

May 1, 2024

Primary Completion Date

May 1, 2027

Study Completion Date

December 31, 2029

Conditions
Esophageal Cancer
Interventions
DEVICE

Ultrasonic teeth cleaning plus Tinidazole microneedle patches applying

After gargling with compound chlorhexidine rinse or 3% hydrogen peroxide rinse for 1 minute, ultrasonic teeth cleaning was performed. After teeth cleaning, the wound was rinsed with 3% hydrogen peroxide and bleeding was stopped. After ultrasonic teeth cleaning, two metronidazole oral composite microneedle patches were immediately applied to the upper and lower gums near the inner side of the first molar, especially where the teeth were lost or damaged. The mouth was kept closed for 15 minutes. After the microneedles were fully degraded, the patient could leave the clinic.

Trial Locations (1)

471003

The Clinical Medical College, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang

All Listed Sponsors
collaborator

Shanghai Zhongshan Hospital

OTHER

lead

The First Affiliated Hospital of Henan University of Science and Technology

OTHER