Corticosteroids Before Extubation in Pediatric Intensive Care Unit

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

348

Participants

Timeline

Start Date

June 15, 2025

Primary Completion Date

June 30, 2028

Study Completion Date

July 31, 2028

Conditions
Intensive Care Pediatric
Interventions
DRUG

Dexamethasone IV

IV-DXM 4mg/ml, injectable solution. Dosage of 0.25 mg/kg (maximum 5 mg per dose), prepared in a syringe of 5 to 10 ml and administered intravenously to the patient over 10 minutes every 6 hours. The treatment duration ranges from 6 hours (minimum of two doses: H0, H6) to 18 hours (maximum of four doses: H0, H6, H12, H18).

OTHER

Placebo

Placebo: 0.9% NaCl solution, prepared in a syringe of 5 to 10 ml and administered intravenously to the patient over 10 minutes every 6 hours. The treatment duration ranges from 6 hours (minimum of two doses: H0, H6) to 18 hours (maximum of four doses: H0, H6, H12, H18).

All Listed Sponsors
lead

Assistance Publique - Hôpitaux de Paris

OTHER