Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Post-operative Pain

NANot yet recruitingINTERVENTIONAL
Enrollment

1,316

Participants

Timeline

Start Date

January 1, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

April 30, 2027

Conditions
OxycodoneChronic Pain, Postoperative
Interventions
DRUG

oxycodone and parecoxib sodium combinations

Participants will receive 0.1ml/kg oxycodone (1mg/ml) and 2 ml parecoxib sodium (20 mg/ml) combinations after the anesthesia induction but before the surgical incision. Oxycodone is administered 5 minutes after parecoxib sodium administration.

DRUG

Placebo and parecoxib sodium combinations

Participants will receive 0.1ml/kg placebo (0.9% saline) and 2 ml parecoxib sodium (20 mg/ml) combinations after the anesthesia induction but before the surgical incision. Placebo is administered 5 minutes after parecoxib sodium administration.

All Listed Sponsors
collaborator

Jinhua Central Hospital

OTHER

collaborator

Minda Hospital of Hubei Minzu University

UNKNOWN

collaborator

Taihe Hospital of Traditional Chinese Medicine

UNKNOWN

collaborator

Qujing first people's Hospital

UNKNOWN

lead

Ailin Luo

OTHER

NCT06721988 - Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Post-operative Pain | Biotech Hunter | Biotech Hunter