Retrograde and Antegrade Enema for Prevention of LARS After LAR: a Randomized Controlled Trial

NANot yet recruitingINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

March 25, 2025

Primary Completion Date

December 30, 2026

Study Completion Date

December 30, 2026

Conditions
Low Anterior Resection Syndrome
Interventions
OTHER

transanal irrigation

The enema is administered retrogradely via the anus. The enema commences one month post-operatively for patients with well-healed wounds, absence of stoma-related complications, and no evidence of anastomotic leakage upon digital examination, until ileostomy reversal. the catheter is gently and slowly inserted 7-10 cm through the anus. The initial irrigation volume is set at 500 ml and is gradually increased based on the patient's tolerance, up to a maximum of 1000 ml. 39-41°C warm water is the choice. Enemas are administered twice weekly, with each session limited to a duration of 30 minutes.

OTHER

antegrade enema

The enema is administered through the distal end of the ileocecal stoma, directed towards the anus. The enema commences one month post-operatively for patients with well-healed wounds, absence of stoma-related complications, and no evidence of anastomotic leakage upon digital examination, until ileostomy reversal. Using a disposable catheter, insert it about 20 cm. The initial irrigation volume is set at 500 ml and is gradually increased based on the patient's tolerance, up to a maximum of 1000 ml. 39-41°C warm water is the choice. Enemas are administered twice weekly, with each session limited to a duration of 30 minutes.

Trial Locations (1)

Unknown

Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Afffliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan

All Listed Sponsors
lead

Sichuan Cancer Hospital and Research Institute

OTHER

NCT06717854 - Retrograde and Antegrade Enema for Prevention of LARS After LAR: a Randomized Controlled Trial | Biotech Hunter | Biotech Hunter