A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,046

Participants

Timeline

Start Date

January 27, 2025

Primary Completion Date

July 2, 2029

Study Completion Date

March 29, 2032

Conditions
Diffuse Large B-Cell Lymphoma
Interventions
BIOLOGICAL

Zilovertamab vedotin

IV infusion

BIOLOGICAL

Rituximab

IV infusion

DRUG

Cyclophosphamide

IV infusion

DRUG

Doxorubicin

IV infusion

BIOLOGICAL

Rituximab Biosimilar

IV infusion

DRUG

Prednisone

Per Approved Product Label

DRUG

Prednisolone

Oral administration

DRUG

Vincristine

IV infusion

DRUG

Rescue medication

Participants receive rescue medication at the investigator's discretion, per approved product label. The recommended rescue medication is granulocyte colony-stimulating factor (G-CSF).

Trial Locations (223)

114

RECRUITING

Tri-Service General Hospital ( Site 3906), Taipei

333

RECRUITING

Chang Gung Memorial Hospital - Linkou Branch ( Site 3903), Taoyuan

704

RECRUITING

National Cheng Kung University Hospital ( Site 3902), Tainan City

2800

RECRUITING

AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 1102), Mechelen

3350

RECRUITING

Grampians Health ( Site 3003), Ballarat

4400

RECRUITING

Szabolcs Szatmár Bereg Vármegyei Oktatókórház ( Site 1704), Nyíregyháza

4814

RECRUITING

Townsville University Hospital ( Site 3006), Douglas

5000

RECRUITING

Royal Adelaide Hospital ( Site 3001), Adelaide

5404

RECRUITING

Kantonspital Baden ( Site 2703), Baden

6000

RECRUITING

Royal Perth Hospital-Haematology ( Site 3004), Perth

6501

RECRUITING

Ospedale Regionale Bellinzona e Valli ( Site 2701), Bellinzona

6900

RECRUITING

Ospedale Italiano Lugano (OIL) ( Site 2705), Lugano

7000

RECRUITING

ASBL CHU Helora - Hôpital de Mons - Site Kennedy ( Site 1103), Mons

7100

RECRUITING

Antalya Egitim ve Arastirma Hastanesi ( Site 2805), Antalya

7400

RECRUITING

Regionshospitalet Gødstrup ( Site 1301), Herning

7580

RECRUITING

Haemalife ( Site 2501), Cape Town

7925

RECRUITING

Groote Schuur Hospital ( Site 2504), Cape Town

9000

RECRUITING

Aalborg University Hospital ( Site 1302), Aalborg

RECRUITING

Cantonal Hospital St.Gallen-Oncology & Hematology ( Site 2702), Sankt Gallen

10002

RECRUITING

National Taiwan University Hospital ( Site 3901), Taipei

10060

RECRUITING

Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia ( Site 2010), Candiolo

10330

RECRUITING

Chulalongkorn University ( Site 4003), Pathumwan

10408

RECRUITING

National Cancer Center- Center for Hemotologic malignancy ( Site 3806), Goyang-si

10449

RECRUITING

Mackay Memorial Hospital ( Site 3908), Taipei

10700

RECRUITING

Faculty of Medicine Siriraj Hospital ( Site 4001), Bangkoknoi

12206

RECRUITING

New York Oncology Hematology, P.C. ( Site 0129), Albany

14001

RECRUITING

Clínicas AUNA Sede Chiclayo ( Site 0904), Chiclayo

15038

RECRUITING

INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 0901), Surquillo

15072

RECRUITING

Clínica San Felipe ( Site 0906), Lima

RECRUITING

Hospital Nacional Edgardo Rebagliati Martins ( Site 0903), Lima

15087

RECRUITING

Hospital Nacional Dos De Mayo ( Site 0905), Lima

15208

RECRUITING

Poria Medical Center ( Site 1902), Tiberias

17000

RECRUITING

Hopital Saint Louis, Centre Hospitalier de La Rochelle ( Site 1511), La Rochelle

18009

RECRUITING

MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( Site 2904), Cherkasy

20132

RECRUITING

IRCCS Ospedale San Raffaele ( Site 2012), Milan

20141

RECRUITING

IEO Istituto Europeo di Oncologia ( Site 2009), Milan

20900

RECRUITING

Fondazione IRCCS San Gerardo dei Tintori ( Site 2008), Monza

21000

RECRUITING

CHU Dijon Bourgogne ( Site 1516), Dijon

22903

RECRUITING

University of Virginia Cancer Center ( Site 0138), Charlottesville

23229

RECRUITING

Virginia Cancer Institute ( Site 0148), Richmond

24014

RECRUITING

Blue Ridge Cancer Care ( Site 0132), Roanoke

25123

RECRUITING

Azienda Ospedaliera Spedali Civili di Brescia-Hemathology ( Site 2001), Brescia

27000

RECRUITING

CIMAB SA de CV ( Site 0807), Torreón

28046

RECRUITING

Hospital Universitario La Paz ( Site 2611), Madrid

28100

RECRUITING

Azienda Ospedaliero Universitaria Maggiore della Carità ( Site 2004), Novara

29000

RECRUITING

Khmelnytskyi Regional Hospital ( Site 2907), Khmelnytskiy

29010

RECRUITING

Hospital Virgen de la Victoria ( Site 2609), Málaga

33013

RECRUITING

Bioresearch Partner ( Site 0157), Hialeah

34722

RECRUITING

Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi ( Site 2804), Istanbul

35015

RECRUITING

Chungnam National University Hospital ( Site 3801), Daejeon

35016

RECRUITING

H. Insular de Gran Canaria ( Site 2606), Las Palmas de Gran Canaria

37920

RECRUITING

The University of Tennessee Medical Center ( Site 0142), Knoxville

38700

RECRUITING

CHU GRENOBLE ALPES ( Site 1518), La Tronche

40207

RECRUITING

Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0163), Louisville

40536

RECRUITING

University of Kentucky ( Site 0106), Lexington

41009

RECRUITING

Hospital Universitario Virgen Macarena ( Site 2608), Seville

42000

RECRUITING

Grupo Ollin Care ( Site 0806), Pachuca

46804

RECRUITING

Fort Wayne Medical Oncology and Hematology ( Site 0149), Fort Wayne

47500

RECRUITING

Sunway Medical Centre ( Site 3406), Petaling Jaya

48121

RECRUITING

Ospedale Santa Maria delle Croci ( Site 2006), Ravenna

49241

RECRUITING

Pusan National University Hospital ( Site 3804), Busan

49503

RECRUITING

Corewell Health ( Site 0130), Grand Rapids

50009

RECRUITING

Hospital Universitario Miguel Servet ( Site 2607), Zaragoza

50200

RECRUITING

Maharaj Nakorn Chiang Mai Hospital ( Site 4002), Muang

53715

RECRUITING

SSM Health Dean Medical Group ( Site 0140), Madison

55270

RECRUITING

Ondokuz Mayıs Universitesi ( Site 2806), Korfez Mahallesi

57085

RECRUITING

Centre Hospitalier Régional Metz Thionville - Hôpital de Mercy ( Site 1515), Metz

57104

RECRUITING

Sanford Cancer Center ( Site 0143), Sioux Falls

58260

RECRUITING

Centro de Investigacion Clinica Chapultepec ( Site 0803), Morelia

59030

RECRUITING

Namık Kemal University Medical Faculty ( Site 2807), Suleymanpasa

59385

RECRUITING

Centre Hospitalier de Dunkerque ( Site 1513), Dunkirk

60126

RECRUITING

AOU delle Marche Ospedali Riuniti di Ancona ( Site 2011), Ancona

62269

RECRUITING

Cancer Care Specialists of Illinois ( Site 0152), O'Fallon

63100

RECRUITING

Centre Hospitalier Universitaire Estaing ( Site 1508), Clermont-Ferrand

64100

RECRUITING

Centre Hospitalier de la Cote Basque ( Site 1509), Bayonne

64108

RECRUITING

Truman Medical Center ( Site 0122), Kansas City

64460

RECRUITING

"Hospital Universitario Dr. Jose Eleuterio Gonzalez ( Site 0802)", Monterrey

66606

RECRUITING

Cotton O'Neil Cancer Center ( Site 0108), Topeka

68000

RECRUITING

Hospital Ampang ( Site 3404), Selangor Darul Ehsan

68020

RECRUITING

Centro de Investigacion Clinica de Oaxaca ( Site 0805), Oaxaca City

76008

RECRUITING

"Communal non-profit enterprise Regional clinical hospital of Ivano-Frankivsk Regional Council ( Site 2906)", Ivano-Frankivsk

77030

RECRUITING

Center for Oncology and Blood Disorders ( Site 0153), Houston

79057

RECRUITING

Institute of Blood Pathology and Transfusion Medicine AMS Ukraine ( Site 2903), Lviv

83301

RECRUITING

Chang Gung Memorial Hospital at Kaohsiung ( Site 3905), Kaohsiung City

83800

RECRUITING

HIA Sainte Anne ( Site 1506), Toulon

84000

RECRUITING

Centre Hospitalier d'Avignon ( Site 1505), Avignon

85000

RECRUITING

CHD Vendee ( Site 1502), La Roche-sur-Yon

85028

RECRUITING

IRCCS Crob ( Site 2002), Rionero in Vulture

85719

RECRUITING

The University of Arizona Cancer Center - North Campus ( Site 0124), Tucson

87042

RECRUITING

Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1512), Limoges

88586

RECRUITING

Queen Elizabeth Hospital ( Site 3405), Kota Kinabalu

89102

RECRUITING

OptumCare Cancer Care ( Site 0121), Las Vegas

89169

RECRUITING

Comprehensive Cancer Centers of Nevada ( Site 0113), Las Vegas

90048

RECRUITING

Cedars-Sinai Medical Center ( Site 0115), Los Angeles

90146

RECRUITING

Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO ( Site 2005), Palermo

90720

RECRUITING

Cancer Blood and Specialty Clinic ( Site 0109), Los Alamitos

92210

RECRUITING

Institut Curie - site Saint-Cloud ( Site 1501), Saint-Cloud

93586

RECRUITING

Sarawak General Hospital ( Site 3402), Kuching

98000

RECRUITING

Hospital Miri ( Site 3403), Miri

100096

RECRUITING

Peking University Third Hospital ( Site 3102), Beijing

100142

RECRUITING

Beijing Cancer Hospital ( Site 3101), Beijing

110231

ACTIVE_NOT_RECRUITING

Hospital Universitario San Ignacio ( Site 0607), Bogotá

119074

RECRUITING

National University Hospital ( Site 3702), Singapore

130021

RECRUITING

The First Hospital Of Jilin University ( Site 3103), Changchun

168583

RECRUITING

National Cancer Centre Singapore ( Site 3701), Singapore

200032

RECRUITING

Fudan University Shanghai Cancer Center ( Site 3115), Shanghai

226001

RECRUITING

Affiliated Hospital of Nantong University ( Site 3117), Nantong

230002

RECRUITING

IMAT S.A.S ( Site 0603), Montería

230031

RECRUITING

Anhui Provincial Cancer Hospital ( Site 3124), Hefei

250117

RECRUITING

Shandong Cancer Hospital ( Site 3108), Jinan

276001

RECRUITING

LinYi Cancer Hospital ( Site 3104), Linyi

301617

RECRUITING

Institute of Hematology and Blood Diseases Hosp CAMS&PUMC ( Site 3105), Tianjin

310009

RECRUITING

The First Affiliated Hospital, Zhejiang Medical University ( Site 3116), Hangzhou

330029

RECRUITING

Jiangxi Cancer Hospital ( Site 3118), Nanchang

350014

RECRUITING

Fujian Provincial Cancer Hospital. ( Site 3119), Fuzhou

361003

RECRUITING

The First Affiliated Hospital of Xiamen University ( Site 3120), Xiamen

400030

RECRUITING

Chongqing Cancer Hospital ( Site 3113), Chongqing

430079

RECRUITING

Hubei Cancer Hospital ( Site 3125), Wuhan

500052

RECRUITING

Centrul de Diagnostic si Tratament Oncologic Brasov ( Site 2402), Brasov

510060

RECRUITING

Sun Yat-sen University Cancer Center ( Site 3121), Guangzhou

510280

RECRUITING

Zhujiang Hospital of Southern Medical University ( Site 3122), Guangzhou

530021

RECRUITING

Affiliated Cancer Hospital of Guangxi Medical University ( Site 3123), Nanning

550004

RECRUITING

The Affiliated Hospital of Guizhou Medical University ( Site 3112), Guiyang

550245

RECRUITING

Spital Judetean Sibiu ( Site 2405), Sibiu

610041

RECRUITING

Sichuan Cancer Hospital. ( Site 3111), Chengdu

RECRUITING

West China Hospital, Sichuan University ( Site 3110), Chengdu

650118

RECRUITING

Yunnan Province Cancer Hospital ( Site 3109), Kunming

660001

RECRUITING

Oncologos del Occidente ( Site 0601), Pereira

710061

RECRUITING

1st Affil Hosp of Med College of Xi'an Jiaotong University ( Site 3107), Xi’an

760032

RECRUITING

Fundación Valle del Lili ( Site 0602), Santiago de Cali

1720430

RECRUITING

IC La Serena Research ( Site 0504), La Serena

2540488

RECRUITING

Centro de Investigaciones ( Site 0511), Viña del Mar

3436212

RECRUITING

Carmel Hospital ( Site 1903), Haifa

4003437

RECRUITING

Institutul Oncologic Cluj ( Site 2404), Cluj-Napoca

4070196

RECRUITING

Biocenter ( Site 0510), Concepción

5112129

RECRUITING

Oncocentro Valdivia ( Site 0506), Valdivia

6423906

RECRUITING

Sourasky Medical Center ( Site 1904), Tel Aviv

7500653

RECRUITING

Centro de Estudios Clínicos SAGA ( Site 0508), Santiago

7500921

RECRUITING

FALP ( Site 0501), Santiago

7580206

RECRUITING

Clinica Inmunocel ( Site 0503), Santiago

7650018

RECRUITING

Clínica RedSalud Vitacura ( Site 0512), Santiago

8420383

RECRUITING

Bradfordhill ( Site 0502), Santiago

9112001

RECRUITING

Hadassah Medical Center ( Site 1901), Jerusalem

C1430EGF

RECRUITING

Clinica Adventista Belgrano ( Site 0309), Caba.

B7600FZO

RECRUITING

Instituto de Investigaciones Clinicas Mar del Plata ( Site 0306), Mar del Plata

B1629AHJ

RECRUITING

Hospital Universitario Austral ( Site 0307), Pilar

C1118AAT

RECRUITING

Hospital Aleman ( Site 0301), Buenos Aites

S2000CEJ

RECRUITING

Fundacion Estudios Clinicos ( Site 0311), Rosario

T4000IKO

RECRUITING

C.I.C.E. 9 de Julio ( Site 0305), San Miguel de Tucumán

C1199ABB

RECRUITING

Hospital Italiano de Buenos Aires ( Site 0304), CABA

J5400ARW

RECRUITING

Clinica EL Castaño ( Site 0312), San Juan

85802-080

RECRUITING

CEONC ( Site 0412), Cascavel

82520-060

RECRUITING

Hospital Erasto Gaertner ( Site 0401), Curitiba

59062-000

RECRUITING

Liga Norte Riograndense Contra o Cancer ( Site 0407), Natal

88020-210

RECRUITING

CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina ( Site 0403), Florianópolis

14026-610

RECRUITING

Hope ( Site 0413), Ribeirão Preto

13561-130

RECRUITING

Clinica Advanze ( Site 0411), São Carlos

15090-000

RECRUITING

F. F. R. M. São Jose do Rio Preto ( Site 0404), SJRP

01321-001

RECRUITING

Hospital Paulistano ( Site 0406), São Paulo

05403-010

RECRUITING

Hospital das Clinicas FMUSP ( Site 0402), São Paulo

L1G 2B9

RECRUITING

Lakeridge Health - The R.S. McLaughlin Durham Regional Cancer Centre (MDRCC) ( Site 0206), Oshawa

030013

RECRUITING

Shanxi Cancer Hospital ( Site 3106), Taiyuan

050034

RECRUITING

Hospital Pablo Tobon Uribe ( Site 0604), Medellín

06189

RECRUITING

Centre Antoine-Lacassagne ( Site 1514), Nice

106 76

RECRUITING

Evangelismos General Hospital of Athens ( Site 1602), Athens

115 26

RECRUITING

"General Hospital of Athens Laiko-Hematology Department ( Site 1603)", Athens

124 62

RECRUITING

Attikon University General Hospital of Athens ( Site 1604), Athens

681 00

RECRUITING

University General Hospital of Alexandroupoli ( Site 1601), Alexandroupoli

01009

RECRUITING

MEDI-K ( Site 0701), Guatemala City

01010

RECRUITING

CELAN,S.A ( Site 0702), Guatemala City

RECRUITING

Cen Integral Onco Gastro y Hemato Onco Guatemala S.A. ( Site 0703), Guatemala City

Unknown

RECRUITING

Princess Margaret Hospital ( Site 3202), Hong Kong

RECRUITING

Queen Mary Hospital ( Site 3201), Hong Kong

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 2003), Roma

466-8560

RECRUITING

Nagoya University Hospital ( Site 3309), Nagoya

791-0280

RECRUITING

National Hospital Organization Shikoku Cancer Center ( Site 3321), Matsuyama

650-0047

RECRUITING

Kobe City Medical Center General Hospital ( Site 3318), Kobe

920-8641

RECRUITING

Kanazawa University Hospital ( Site 3308), Kanazawa

259-1193

RECRUITING

Tokai University Hospital ( Site 3302), Isehara

980-8574

RECRUITING

Tohoku University Hospital ( Site 3301), Sendai

589-8511

RECRUITING

Kindai University Hospital ( Site 3310), Sayama

350-0495

RECRUITING

Saitama Medical University Hospital ( Site 3305), Iruma-gun

113-8431

RECRUITING

Juntendo University Hospital ( Site 3307), Bunkyo

113-8677

RECRUITING

Tokyo Metropolitan Komagome Hospital ( Site 3323), Bunkyo

409-3898

RECRUITING

University of Yamanashi Hospital ( Site 3320), Chūō

260-8717

RECRUITING

Chiba Cancer Center ( Site 3314), Chiba

812-8582

RECRUITING

Kyushu University Hospital ( Site 3313), Fukuoka

730-8619

RECRUITING

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital ( Site 3322), Hiroshima

602-8566

RECRUITING

University Hospital,Kyoto Prefectural University of Medicine ( Site 3315), Kyoto

889-1692

RECRUITING

University of Miyazaki Hospital ( Site 3319), Miyazaki

700-8558

RECRUITING

Okayama University Hospital ( Site 3311), Okayama

545-8586

RECRUITING

Osaka Metropolitan University Hospital ( Site 3317), Osaka

990-9585

RECRUITING

Yamagata University Hospital ( Site 3312), Yamagata

03100

RECRUITING

Health Pharma Professional Research S.A. de C.V. ( Site 0801), Mexico City

03104

RECRUITING

Centro de Infusion Superare ( Site 0804), Mexico City

3318 AT

RECRUITING

Albert Schweitzer Ziekenhuis ( Site 2103), Dordrecht

3813 TZ

RECRUITING

Meander Medisch Centrum ( Site 2101), Amersfoort

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 2201), Warsaw

76-200

RECRUITING

Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku ( Site 2210), Słupsk

44-102

RECRUITING

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2208), Gliwice

40-519

RECRUITING

Pratia Onkologia Katowice ( Site 2204), Katowice

10-228

RECRUITING

Szpital Kliniczny Ministerstwa Spraw Wewnętrznych i Administracji z Warmińsko-Mazurskim Centrum Onko ( Site 2205), Olsztyn

4710-243

RECRUITING

Unidade Local de Saude de Braga - Hospital de Braga ( Site 2306), Braga

4200-072

RECRUITING

Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E. ( Site 2302), Porto

00682

RECRUITING

BRCR Global - Mayaguez ( Site 1003), Mayagüez

00918

RECRUITING

Auxilio Mutuo Cancer Center ( Site 1001), San Juan

030171

RECRUITING

Spitalul Clinic Colțea ( Site 2401), Bucharest

0181

RECRUITING

Netcare Pretoria East Hospital ( Site 2502), Pretoria

03722

RECRUITING

Severance Hospital, Yonsei University Health System ( Site 3802), Seoul

05505

RECRUITING

Asan Medical Center ( Site 3803), Seoul

06351

RECRUITING

Samsung Medical Center ( Site 3807), Seoul

07345

RECRUITING

St.Mary's H., Youido ( Site 3805), Seoul

08908

RECRUITING

ICO L Hospitalet ( Site 2601), L'Hospitalet de Llobregat

03010

RECRUITING

Hospital General Universitario Dr. Balmis ( Site 2604), Alicante

08003

RECRUITING

Hospital del Mar ( Site 2610), Barcelona

01120

RECRUITING

Baskent Universitesi Adana Dr. Turgut Noyan UAM ( Site 2809), Adana

06200

RECRUITING

Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi ( Site 2803), Ankara

06230

RECRUITING

Hacettepe Universite Hastaneleri ( Site 2810), Ankara

06620

RECRUITING

Ankara University Faculty of Medicine ( Site 2801), Ankara

03022

RECRUITING

SNPE National Cancer Institute ( Site 2902), Kyiv

03057

RECRUITING

Universal Clinic Oberig ( Site 2908), Kyiv

03115

RECRUITING

SI National Research Center of Radiation Medicine, Hematology, Oncology ( Site 2901), Kyiv

04112

RECRUITING

Public Non-Profit Enterprise Kyiv City Clinical Hospital #9 under the Executive Body of Kyiv City Co ( Site 2905), Kyiv

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY