How Many Dexamethasone Doses Should Be Given Perioperatively?

PHASE4RecruitingINTERVENTIONAL
Enrollment

339

Participants

Timeline

Start Date

March 25, 2025

Primary Completion Date

January 1, 2026

Study Completion Date

January 1, 2027

Conditions
Arthropathy of Knee
Interventions
DRUG

Dexamethasone IV

Patients will receive dexamethasone administered intraoperatively at the time of anesthesia. The dose of dexamethasone will be 16mg intravenous (IV) if you do not have a prior diagnosis of diabetes mellitus, or 8mg IV if you do have a previous diagnosis of diabetes mellitus.

DRUG

Dexamethasone IV+Oral

Patients will receive dexamethasone administered intraoperatively and on the morning of the first postoperative day. The dose of dexamethasone will be 16mg intravenous (IV) if you do not have a prior diagnosis of diabetes mellitus, or 8mg IV if you do have a previous diagnosis of diabetes mellitus. The medication will be intravenously administered while inpatient, and via oral route when discharged.

DRUG

Dexamethasone IV+Oral 2 Day

Patients will receive dexamethasone administered intraoperatively, the morning of the first postoperative day, and the morning of the second postoperative day. The dose of dexamethasone will be 16mg intravenous (IV) if you do not have a prior diagnosis of diabetes mellitus, or 8mg IV if you do have a previous diagnosis of diabetes mellitus. The medication will be intravenously administered while inpatient, and via oral route when discharged.

Trial Locations (1)

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Mayo Clinic

OTHER

NCT06715709 - How Many Dexamethasone Doses Should Be Given Perioperatively? | Biotech Hunter | Biotech Hunter