NCT06715241View on ClinicalTrials.gov

A MULTICENTER, SEEKING SIGNAL, RANDOMISED, OPEN-LABEL PHASE II OF RELATLIMAB AND NIVOLUMAB VS NIVOLUMAB ALONE IN LOCALLY ADVANCED CERVICAL CANCERS

PHASE2RecruitingINTERVENTIONAL
Enrollment

77

Participants

Timeline

Start Date

December 11, 2024

Primary Completion Date

December 31, 2030

Study Completion Date

December 31, 2030

Conditions
LOCALLY ADVANCED CERVICAL CANCERS
Interventions
COMBINATION_PRODUCT

combination of relatlimab and nivolumab wich are two immunotherapy treatments

Induction: Nivolumab 360 mg/relatlimab 360 mg fixed dose combination, IV, 6 weeks Off treatment period: 4 to 6 weeks Maintenance: Nivolumab 480 mg/relatlimab 480 mg fixed dose combination, IV 13 cycles (Q4W): 52 weeks

OTHER

Nivolumab alone

Induction: Nivolumab alone 360 mg, IV2 cycles (Q3W): 6 weeks Off treatment period: 4 to 6 weeks Maintenance: Nivolumab alone 480 mg, IV, 13 cycles (Q4W): 52 weeks

Trial Locations (31)

13273

RECRUITING

Institut Paoli Calmettes, Marseille

14076

RECRUITING

Centre François Baclesse, Caen

21079

RECRUITING

CHU de Dijon, Dijon

22190

RECRUITING

Centre CARIO - HPCA, Plérin

25030

RECRUITING

CHRU Besançon - Hôpital Jean Minjoz, Besançon

29200

RECRUITING

CHU de BREST - Hôpital Cavale Blanche, Brest

31059

NOT_YET_RECRUITING

Oncopole Claudius Regaud, Toulouse

33076

RECRUITING

Institut Bergonié, Bordeaux

34298

WITHDRAWN

ICM Val d'Aurelle, Montpellier

35042

RECRUITING

Centre Eugène Marquis, Rennes

37044

WITHDRAWN

CHRU de Tours - Hôpital Bretonneau - Centre Henry Kaplan, Tours

37170

RECRUITING

Recherche Oncologique Clinique 37 (ROC 37), Tours

42271

RECRUITING

CHU Saint-Etienne - Pôle de Cancérologie, Saint-Etienne

44805

RECRUITING

ICO - Centre René Gauducheau, Saint-Herblain

49055

RECRUITING

ICO Paul Papin, Angers

54519

RECRUITING

ICL - Centre Alexis Vautrin, Vandœuvre-lès-Nancy

59000

NOT_YET_RECRUITING

CHRU Lille - Hôpital Jeanne de Flandre, Lille

67200

RECRUITING

ICANS - Institut de cancérologie Strasbourg Europe, Strasbourg

69373

RECRUITING

Centre Léon Bérard, Lyon

75005

RECRUITING

Institut Curie, Paris

75012

RECRUITING

Groupe Hospitalier Diaconesses - Croix Saint-Simon, Paris

84918

RECRUITING

Sainte-Catherine Institut du Cancer Avignon-Provence, Avignon

86021

NOT_YET_RECRUITING

CHU de Poitiers - Hôpital de la Milétrie, Poitiers

87042

RECRUITING

CHU de Limoges - Hôpital Dupuytren, Limoges

94805

RECRUITING

Gustave Roussy, Villejuif

Unknown

NOT_YET_RECRUITING

Centre Jean Perrin, Clermont-Ferrand

RECRUITING

Centre Hospitalier Intercommunal de Créteil, Créteil

RECRUITING

[email protected], Dijon

NOT_YET_RECRUITING

Centre Oscar Lambret, Lille

NOT_YET_RECRUITING

Centre Hospitalier Lyon Sud, Pierre-Bénite

06189

RECRUITING

Centre Antoine Lacassagne, Nice

All Listed Sponsors
lead

ARCAGY/ GINECO GROUP

OTHER