Safety and Effectiveness of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

439

Participants

Timeline

Start Date

February 3, 2025

Primary Completion Date

April 30, 2028

Study Completion Date

September 30, 2028

Conditions
Extensive-stage Small-cell Lung Cancer
Interventions
DRUG

BNT327

Solution for intravenous infusion

DRUG

Atezolizumab

Concentrate for solution for intravenous infusion

DRUG

Etoposide

Solution for infusion

DRUG

Carboplatin

Solution for infusion

Trial Locations (57)

1130

Acibadem Adana Hospital, Adana

1140

Seyhan Medical Park Hospital, Adana

1250

Baskent University Adana Turgut Noyan Application and Research Center, Adana

2298

Calvary Mater Newcastle, Waratah

2500

Cancer Care Wollongong Pty Limited, Wollongong

3021

Western Health Sunshine Hospital, St Albans

3084

Olivia Newton-John Cancer Wellness & Research centre, Heidelberg

3199

Peninsula & South Eastern Haematology and Oncology Group, Frankston

3722

Severance Hospital, Yonsei University Health System, Seoul

5011

The Queen Elizabeth Hospital, Woodville

5037

Icon Cancer Centre Kurralta Park, Kurralta Park

5505

Asan Medical Center (AMC), Seoul

6010

Gulhane Training and Research Hospital, Ankara

6200

Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara

6230

Hacettepe University Medical Faculty Hospital, Ankara

6351

Samsung Medical Center, Seoul

6520

Memorial Ankara Hospital, Ankara

6560

Gazi University, Medical Faculty Hospital, Ankara

6680

Liv Hospital Ankara, Ankara

6800

Ankara Bilkent City Hospital, Ankara

8308

Korea University Guro Hospital, Seoul

10408

National Cancer Center, Goyang-si

16247

The Catholic University Of Korea, St. Vincent's Hospital, Suwon

16499

Ajou University Hospital, Suwon

21565

Gachon University Gil Medical Center, Incheon

22408

Hematology Oncology Associates of Fredericksburg, Inc., Fredericksburg

34010

Koc Universitesi Hastanesi (Koc University Hospital), Istanbul

34295

Medical Park Florya Hospital, Istanbul

34711

Clermont Oncology Center, Clermont

34718

Yeditepe University Kosuyolu Hospital, Istanbul

35575

Medical Point Izmir Hospital, Izmir

37920

University of Tennessee Medical Center, Knoxville

38671

Baptist Cancer Center, Southaven

41380

Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul

Kocaeli University Medical Faculty Hospital, Kocaeli

46804

Fort Wayne Medical Oncology and Hematology, Inc, Fort Wayne

50010

McFarland Clinic, Ames

52403

Helen G. Nassif Community Cancer Center, Cedar Rapids

52727

Gyeongsang National University Hospital (GNUH), Jinju

54290

Sakarya University Training and Research Hospital, Sakarya

68506

Nebraska Hematology-Oncology (NHO), Lincoln

77090

Millennium Research and Clinical Development, LLC, Houston

130012

Jilin Cancer Hospital, Changchun

Unknown

Akdeniz University Hospital, Antalya

M20 4BX

The Christie NHS Foundation Trust, Manchester

SW3 6JJ

Royal Marsden Hospital (RMH) - Royal Marsden NHS Foundation Trust, Chelsea

SM2 5PT

Royal Marsden Hospital (Sutton) - Royal Marsden NHS Foundation Trust, Sutton

HD3 3EA

Huddersfield Royal Infirmary - Calderdale and Huddersfield NHS Foundation Trust, Huddersfield

NE7 7DN

Northern Centre for Cancer Care - The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne

NG5 1PB

Nottingham University Hospitals NHS Trust - Nottingham City Hospital, Nottingham

OX3 7LE

Churchill Hospital - Oxford University Hospitals NHS Foundation Trust, Oxford

DD1 9SY

Ninewells Hospital and Medical School - Tayside Health Board, Dundee

TQ2 7AA

Torbay and South Devon NHS Foundation Trust, Torquay

ST4 6QG

Royal Stoke University Hospital - University Hospitals of North Midlands NHS Trust, Stoke-on-Trent

CF14 2TL

Velindre NHS Trust, Velindre Cancer Centre, Cardiff

WV10 0QP

New Cross Hospital, Wolverhampton

LS9 7TF

St James's University Hospital - Leeds Teaching Hospitals NHS Trust, Leeds

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Biotheus Inc.

INDUSTRY

lead

BioNTech SE

INDUSTRY

NCT06712355 - Safety and Effectiveness of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer | Biotech Hunter | Biotech Hunter