Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

186

Participants

Timeline

Start Date

October 31, 2025

Primary Completion Date

December 2, 2026

Study Completion Date

December 2, 2026

Conditions
Major Depressive DisorderMild Neurocognitive DisorderHIV
Interventions
DRUG

Pramipexole ER

Tablets self-administered orally

DRUG

Escitalopram

Tablets self-administered orally

Trial Locations (39)

265

Blantyre CRS, Blantyre

4114

De La Salle Medical and Health Sciences Institute - Angelo King Medical Research Center (DLSMHSI-AKMRC), Dasmariñas

4302

Durban International CRS, Mount Edgecombe

10000

Hanoi Medical University (HMU), Hanoi

10010

Weill Cornell Chelsea CRS, New York

10032

Columbia Physicians & Surgeons (P&S) CRS, New York

10065

Weill Cornell Uptown CRS, New York

10330

Thai Red Cross AIDS Research Centre (TRC-ARC) CRS, Pathum Wan

14080

Nutrición-Mexico CRS, Mexico City

14642

University of Rochester Adult HIV Therapeutic Strategies Network CRS, Rochester

15063

Barranco CRS, Lima

15213

University of Pittsburgh CRS, Pittsburgh

19104

Penn Therapeutics CRS, Philadelphia

20009

Whitman-Walker Institute, Inc. CRS, Washington D.C.

20200

Kenya Medical Research Institute/Walter Reed Project Clinical Research Center (KEMRI/WRP) CRS, Kericho

30100

Moi University Clinical Research Center (MUCRC) CRS, Eldoret

35222

Alabama CRS, Birmingham

37204

Vanderbilt Therapeutics (VT) CRS, Nashville

43210

Ohio State University CRS, Columbus

44106

Case CRS, Cleveland

50200

Chiang Mai University HIV Treatment (CMU HIV Treatment) CRS, Chiang Mai

60611

Northwestern University CRS, Chicago

77030

Houston Advancing Research Team CRS, Houston

80045

University of Colorado Hospital CRS, Aurora

90035

University of California, Los Angeles CARE Center CRS, Los Angeles

90502

Harbor University of California, Los Angeles Center CRS, Torrance

92103

UCSD Antiviral Research Center CRS, San Diego

94110

University of California, San Francisco HIV/AIDS CRS, San Francisco

411001

Byramjee Jeejeebhoy Medical College (BJMC) CRS, Pune

30308-2012

The Ponce de Leon Center CRS, Atlanta

02114

Massachusetts General Hospital CRS (MGH CRS), Boston

63110-1010

Washington University Therapeutics (WT) CRS, St Louis

27599-7215

Chapel Hill CRS, Chapel Hill

27401-1020

Greensboro CRS, Greensboro

45267-0405

Cincinnati CRS, Cincinnati

Unknown

Gaborone CRS, Gaborone

Joint Clinical Research Centre (JCRC)/Kampala CRS, Kampala

Milton Park CRS, Milton Park

21040-900

Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS, Rio de Janeiro

All Listed Sponsors
collaborator

Cipla Ltd.

INDUSTRY

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH