Effect of Exercise on Irisin Levels of Hypothyroid Rats

Fed on normal standard diet

Experimental hypothyroidism will be induced by administration of propylthiouracil for three weeks in the form of tablets diluted in water

Rats will be subjected to chronic swimming. The swimming protocol will consist of 8 weeks of low-intensity swimming exercise. The exercise groups will be adapted to a round water tank (70 cm × 70 cm) containing water at 28 ± 2°C for 3 days (10-45 min/day). The rats will then begin swimming, 45 min/day for the first two weeks at 10am and 60 min/day for the last six weeks at 10am