Feasibility and Efficacy of Automated Lateral Decubitus Therapy in Hypoxemic Respiratory Failure

NAActive, not recruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

December 13, 2021

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Respiratory InsufficiencyARDSPost Cardiac Surgery PatientsHypoxemic Respiratory Failure
Interventions
PROCEDURE

Rotational Therapy

Sample1- Ventilator settings where adjusted with PEEP based on BMI, followed by a 2 cmH2O increase and 20 minutes in a lateral position at 30 degrees for lung recruitment for both sides. And at the end were subjected to an alveolar recruitment maneuver with pressure increases up to a plateau pressure of 45 cmH2O. Sample2- A recruitment maneuver followed by PEEP titration is performed, selecting the PEEP that is above the crossing point between the collapse and hyperdistension curves provided by EIT. And the the PEEP-ARDSNet will be selected according to the low PEEP-FIO2 table from the ARDSNet protocol. Observations are made at 4 and 24 hours, with PEEP at 24 hours adjusted to the level identified by EIT.

Trial Locations (1)

05403-900

Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da USP, São Paulo

All Listed Sponsors
lead

University of Sao Paulo General Hospital

OTHER