266
Participants
Start Date
December 31, 2024
Primary Completion Date
June 30, 2029
Study Completion Date
June 30, 2029
Adjuvant radiotherapy
"Patients will receive an adjuvant radiotherapy corresponding to an equivalent dose of 45 to 50 Gy (Equivalent Dose in 2 Gy Fractions \[EQD2\] with a tumor alpha/beta ratio of 10 Gy) delivered on the operating bed.~Patients will be treated by :~* either external radiation therapy using high-energy electrons or photons:~ * 45 Gy in 15 fractions of 3 Gy~ * 50 Gy in 25 fractions of 2 Gy~* or interstitial brachytherapy or brachytherapy via skin applicators:~ * 36 Gy in 8 fractions of 4.5 Gy~ * 36 Gy in 9 fractions of 4 Gy~ * 40 Gy in 8 fractions of 5 Gy~Radiation therapy should be started within 8 weeks after surgery (or 10 if delayed healing).~Patients will be monitored regularly until the date of the first relapse (local, regional or metastatic), or until the date of death (if no relapse).~Regardless of the type of relapse, remedial treatments will be left to the the investigator's discretion up to the first metastatic relapse."
Centre Georges François Leclerc, Dijon
Centre de Radiothérapie Marie Curie, Valence
Centre Hospitalier de Valence, Valence
Centre Hospitalier Romans - Hopitaux Drôme Nord, Romans-sur-Isère
Centre Hospitalier Régional Universitaire de Brest - Hôpital Morvan, Brest
Centre Hospitalier Universitaire de Bordeaux, Pessac
Centre Hospitalier Universitaire de Rennes, Rennes
Centre Hospitalier Universitaire de Grenoble-Alpes, La Tronche
Centre Hospitalier Simone Veil de Blois, Blois
Centre Hospitalier Universitaire de Saint-Etienne - Hôpital Nord, Saint Priest En Jarez
Centre hospitalier de Roanne, Roanne
Centre Hospitalier Universitaire de Nantes - Hôtel-Dieu, Nantes
Institut Godinot, Reims
Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy
Groupe Hospitalier Bretagne Sud, Lorient
Centre Hospitalier Universitaire Estaing, Clermont-Ferrand
Centre Léon Bérard, Lyon
Centre Hospitalier Annecy Genevois, Épagny-Metz-Tessy
Hôpital Bichat Claude-Bernard, Paris
Centre Hospitalier Universitaire Rouen - Hôpital Charles Nicolle, Rouen
Centre Hospitalier Universitaire Amiens-Picardie, Amiens
Hôpital d'instruction des armées Sainte-Anne, Toulon
Centre Leon Berard
OTHER