Pleural Bleomycin vs Mechanical Abrasion in Malignant Pleural Effusion

NANot yet recruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

December 10, 2024

Primary Completion Date

August 10, 2029

Study Completion Date

October 10, 2029

Conditions
Malignant Pleural Effusion
Interventions
PROCEDURE

Group 1 (mechanical pleurodesis)

pleural abrasions will be done by scrubbing the parietal and visceral pleura until a uniform aspect of bloody pleura by a piece of gauze attached to the end of a holding forceps , intercostal tube will then placed and monitoring of lung expansion will be done through serial CXR and chest ultrasound follow up and when the lung is fully expanded the tube will be clamped for two hours and follow up CXR will be done for follow up and then the tube removed

PROCEDURE

Group 2 chemical pleurodesis by bleomycin)

Those Patients will have indwelling pleural catheter through which pleural fluid will be drained until dryness and then pleurodesis will be done by 60 mg bleomycin dissolved in 50 ml 0.9% saline and 10 ml 2% xylocaine solution then the catheter will be clamped for 6 hours

Trial Locations (1)

71515

Assiut University Faculty of Medicine, Asyut

All Listed Sponsors
lead

Assiut University

OTHER

NCT06691009 - Pleural Bleomycin vs Mechanical Abrasion in Malignant Pleural Effusion | Biotech Hunter | Biotech Hunter