Effect of Non-Invasive Neuromodulation on Primary Chronic Pain, Including Post-COVID-19

NAEnrolling by invitationINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

April 21, 2024

Primary Completion Date

December 16, 2024

Study Completion Date

December 16, 2024

Conditions
Post COVID ConditionChronic PainHealthy
Interventions
DEVICE

taVNS - transauricular vagal nerve stimulation

30 minutes of electrical stimulation on the afferent portion of the vagal nerve on the cymba conchae of the ear, in the following configuration: 30 seg ramp up, 30 seg on, 30 seg off in intensity on which the volunteer feels a light tingling.

DEVICE

rPMS - repetitive peripheric magnetic stimulation

Magnetic stimulation on the efferent portion of the vagal nerve on the neck, on the following configuration: 20Hz, 25 pulses in the trein, in every inhalation, for 20 inhalations with 50% of machine capacity (500 pulses total).

DEVICE

rTMS - repetitive transcranial magnetic stimulation

rTMS intermitent theta- burst on the left DLPFC, on the following configuration: 50 Hz in treins of 5Hz, with 110% of the resting motor limiar and 600 pulses in 3 minutes.

DEVICE

taVNS sham

Simulated taVNS (SHAM) on helix left ear, that is the same as taVNS, but during only 1 minute

Trial Locations (1)

09606045

Federal University of ABC, Sâo Bernardo Do Campo

All Listed Sponsors
collaborator

University of Sao Paulo

OTHER

collaborator

Coordination for the Improvement of Higher Education Personnel

OTHER

lead

Federal University of ABC

OTHER