Effect of Timing of Dexamethasone During Induction on Postoperative Outcomes

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

December 1, 2024

Primary Completion Date

December 31, 2025

Study Completion Date

January 31, 2026

Conditions
Postoperative Nausea and Vomiting (PONV)Postoperative PainInflammatory Response to WoundingHyperglycemia Drug InducedHypotension on InductionTiming of Dexamethasone Administration
Interventions
DRUG

Dexamethasone

Dexamethasone will be administered intravenously at varying times during anesthesia induction to assess the impact of timing on postoperative outcomes. Participants will be randomized into one of three groups: one group will receive dexamethasone before the administration of fentanyl, a second group will receive it after the administration of a muscle relaxant, and a third control group will not receive dexamethasone. This timing variation aims to determine the optimal administration point to improve outcomes, including postoperative nausea, pain, glycemic stability, and hemodynamic response.

All Listed Sponsors
collaborator

University Hospital Center Mohammed VI Tangier, Morocco

UNKNOWN

lead

AABDI Mohammed

OTHER

NCT06685991 - Effect of Timing of Dexamethasone During Induction on Postoperative Outcomes | Biotech Hunter | Biotech Hunter