258
Participants
Start Date
February 20, 2025
Primary Completion Date
June 20, 2025
Study Completion Date
August 20, 2025
Titrated administration of propofol to an OAA/S score of 1 as the endpoint
Propofol is titrated at a rate of 0.5 mg/kg/min to achieve an OAA/S score of 1, followed by a maintenance dose of 2-4 mg/kg/h, concurrently with remifentanil 2 ug/kg and rocuronium 0.6 mg/kg for anesthesia induction.
Titrated administration of propofol to an OAA/S score of 2 as the endpoint
Propofol is titrated at a rate of 0.5 mg/kg/min to achieve an OAA/S score of 2, followed by a maintenance dose of 2-4 mg/kg/h, concurrently with remifentanil 2 ug/kg and rocuronium 0.6 mg/kg for anesthesia induction.
Titrated administration of propofol to a BIS value ≤ 60 as the endpoint
Propofol is titrated at a rate of 0.5 mg/kg/min to achieve a BIS value ≤ 60, followed by a maintenance dose of 2-4 mg/kg/h, concurrently with remifentanil 2 ug/kg and rocuronium 0.6 mg/kg for anesthesia induction.
the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou
SanQing Jin
OTHER