Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies

PHASE1RecruitingINTERVENTIONAL
Enrollment

7

Participants

Timeline

Start Date

February 25, 2025

Primary Completion Date

December 2, 2028

Study Completion Date

December 2, 2030

Conditions
Multiple System AtrophyParkinsons Disease
Interventions
PROCEDURE

Sural Nerve Graft to the Substantia Nigra

Participants assigned to this arm will have the sural nerve biopsied from one of their ankles. This cellular tissue will be deposited bilaterally into the substantia nigra area of their brain by a specialized cannula via bilateral scalp incisions and skull burr holes.

PROCEDURE

Sham surgery

Participants assigned to this arm will have the sural nerve from one of their ankles biopsied in the same fashion as the experimental arm. Bilateral incisions will be made on the participants scalp but no burr holes into the skull and no cannula passes into the brain will occur.

Trial Locations (1)

40536

RECRUITING

University of Kentucky, Lexington

All Listed Sponsors
collaborator

University of Kentucky CCTS

UNKNOWN

lead

Craig van Horne, MD, PhD

OTHER