182
Participants
Start Date
November 20, 2024
Primary Completion Date
October 31, 2029
Study Completion Date
December 31, 2030
Rovadicitinib
Rovadicitinib is an inhibitor of Janus associated kinases (JAK) family and Rho associated kinases (ROCK). It can inhibit the sustained abnormal activation of the Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway and also inhibit Rho associated kinase 2 (ROCK2). The JAK 1-JAK 2 signaling pathway is a key step in causing inflammation and tissue damage in acute and chronic graft-versus-host disease.
Imatinib
Imatinib tyrosine kinase inhibitor is a small molecule protein kinase inhibitor that has the ability to block one or more protein kinases. Clinically used for the treatment of chronic myeloid leukemia and malignant gastrointestinal stromal tumors.
Methotrexate
Methotrexate is an organic compound, mainly used as an anti folate anti-tumor drug. It inhibits the synthesis of tumor cells by inhibiting dihydrofolate reductase, thereby inhibiting the growth and reproduction of tumor cells.
Mycophenolate mofetil
Metoprolol ester is an organic compound mainly used as an immunosuppressant
Rituximab
Rituximab activates antibody dependent cell-mediated phagocytosis and complement dependent cytotoxicity by binding to cluster of differentiation 20 (CD20) antigen, clearing malignant B cells expressing CD20 and achieving therapeutic goals.
NOT_YET_RECRUITING
Peking University First Hospital, Beijing
NOT_YET_RECRUITING
Peking University People's Hospital, Beijing
NOT_YET_RECRUITING
The First Hospital of China Medical University, Shenyang
NOT_YET_RECRUITING
First Hospital of Jilin University, Changchun
NOT_YET_RECRUITING
Shanghai Jiao Tong University School of Medicine，Renji Hospital, Shanghai
NOT_YET_RECRUITING
Ruijin Hospital, Shanghai Jiaotong University School Of Medicine, Shanghai
NOT_YET_RECRUITING
Zhongda Hospital Southeast University, Nanjing
NOT_YET_RECRUITING
Jiangsu Province Hospital, Nanjing
NOT_YET_RECRUITING
Huai'an Second People's Hospital, Huai'an
NOT_YET_RECRUITING
The First Affiliated Hospital of USTC Anhui Provincial Hospital, Hefei
NOT_YET_RECRUITING
Qilu Hospital of Shandong University, Jinan
NOT_YET_RECRUITING
Tai'an City Central Hospital, Tai’an
NOT_YET_RECRUITING
Chinese Academy of Medical Sciences Hematology Hospital, Tianjin
RECRUITING
The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou
NOT_YET_RECRUITING
The Affiliated People's Hospital of Ningbo University, Ningbo
NOT_YET_RECRUITING
The First Affiliated Hospital of Ningbo University, Ningbo
NOT_YET_RECRUITING
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou
NOT_YET_RECRUITING
The First Affiliated Hospital of Nanchang University, Nanchang
NOT_YET_RECRUITING
Fujian Medical University Union Hospital, Fuzhou
NOT_YET_RECRUITING
The First Affiliated Hospital of Xiamen University, Xiamen
NOT_YET_RECRUITING
The Southwest Hospital of AMU, Chongqing
NOT_YET_RECRUITING
Wuhan Union Hospital of China, Wuhan
NOT_YET_RECRUITING
Tongji Hospital Tongji Medical College of HUST, Wuhan
NOT_YET_RECRUITING
Zhongnan Hospital of Wuhan University, Wuhan
RECRUITING
Henan Cancer Hospital, Zhenzhou
NOT_YET_RECRUITING
Henan Provincial People's Hospital, Zhengzhou
NOT_YET_RECRUITING
The Third People's Hospital of Zhengzhou, Zhengzhou
NOT_YET_RECRUITING
Guangzhou First People's Hospital The First People's Hospital Affiliated to Guangzhou Medical University, Guangzhou
NOT_YET_RECRUITING
Nanfang Hospital, Guangzhou
NOT_YET_RECRUITING
The First Affiliated Hospital of Guangxi Medical University, Nanning
NOT_YET_RECRUITING
The Affiliated Hospital of Guizhou Medical University, Guiyang
NOT_YET_RECRUITING
Sichuan Provincial People's Hospital, Chengdu
NOT_YET_RECRUITING
The First People's Hospital of Yunnan Province, Kunming
NOT_YET_RECRUITING
The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an
NOT_YET_RECRUITING
Shanxi Provincial People's Hospital, Xi’an
NOT_YET_RECRUITING
The First Hospital of Lanzhou University, Lanzhou
NOT_YET_RECRUITING
The 904 Hospital of the Joint Service Support Force of the People's Liberation Army of China, Lanzhou
NOT_YET_RECRUITING
The First Hospital of Xinjiang Medical University, Ürümqi
NOT_YET_RECRUITING
The Second Hospital of Hebei Medical Hospital, Shijiazhuang
NOT_YET_RECRUITING
The Second Xiangya Hospital of Central South University, Changsha
NOT_YET_RECRUITING
Shanxi Bethune Hospital, Taiyuan
Lead Sponsor
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
INDUSTRY