Detecting Tumor DNA in the Blood of HR+/HER2-low Metastatic Breast Cancer Patients to Find Candidates for T-DXd Therapy

PHASE2Enrolling by invitationINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

July 30, 2025

Primary Completion Date

August 1, 2028

Study Completion Date

August 1, 2029

Conditions
Breast Cancer MetastaticBreast Cancer Stage IV
Interventions
DRUG

trastuzumab derxutecan

T-DXd will be administrated as an intra-venous injection of 5.4 mg/kg every three weeks (1 cycle = 21-day treatment).

Trial Locations (34)

13009

Institut Paoli Calmettes, Marseille

22190

Hopital Privé Des Côtes D'Armor (Hpca) - Cario, Plérin

29200

Chu de Brest - Hôpital Cavale Blanche, Brest

Clinique Pasteur Lanroze - Cfro - Groupe Vivalto Sante, Brest

34298

Icm Val D'Aurelle, Montpellier

35760

Chp Saint-Grégoire - Groupe Vivalto Sante, Saint-Grégoire

41000

Hôpital Simone Veil de Blois, Blois

49300

Centre Hospitalier de Cholet, Cholet

51100

Institut Godinot, Reims

54100

Medipôle de Nancy - Cog-Ilc (Polyclinique de Gentilly), Nancy

60021

Centre Hospitalier de Beauvais, Beauvais

63000

Pôle Santé République (Elsan), Clermont-Ferrand

63011

Centre Jean Perrin, Clermont-Ferrand

64046

Centre Hospitalier de Pau, Pau

64100

Centre Hospitalier de la Côte Basque, Bayonne

67000

Clinique Sainte-Anne - Gh Saint-Vincent, Strasbourg

69008

Centre Léon Bérard, Lyon

Hopital Prive Jean Mermoz, Lyon

69009

Clinique de La Sauvegarde, Lyon

71100

Centre Hospitalier William Morey, Chalon-sur-Saône

74130

Centre Hospitalier Alpes Léman, Contamine-sur-Arve

74200

Hôpitaux Du Léman, Thonon-les-Bains

75010

Hôpital Saint-Louis, Paris

75020

Groupe Hospitalier Diaconesses Croix Saint-Simon, Paris

80054

Chu Amiens Picardie, Amiens

80090

Clinique de L'Europe Amiens - Cthe, Amiens

83608

Chi Fréjus-Saint-Raphaël, Fréjus

84918

Sainte Catherine Institut Du Cancer Avignon Provence, Avignon

85925

Chd Vendée, La Roche-sur-Yon

89000

Centre Hospitalier D'Auxerre, Auxerre

06189

Centre Antoine Lacassagne, Nice

Unknown

Centre Eugene Marquis, Rennes

Gustave Roussy, Villejuif

054519

Institut de Cancerologie de Lorraine, Vandœuvre-lès-Nancy

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

collaborator

Breast Cancer Research Foundation

OTHER

lead

UNICANCER

OTHER