Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies

NANot yet recruitingINTERVENTIONAL
Enrollment

51

Participants

Timeline

Start Date

December 31, 2024

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
Ventricular Tachycardia (VT)
Interventions
PROCEDURE

Re-Do ventricular tachycardia ablation

1\. Programmed ventricular stimulation (PVS); 2. Mapping during Sinus Rhythm (SR) or right ventricular pacing in pacing dependent patients; 3. Late Potentials identification; 4. VT(s) induction with diastolic pathway mapping when possible; 5. Catheter Ablation in SR or, at the operator's discretion, in VT if tolerated by the patient; 6. If VT is not inducible or the diastolic pathway is not mappable, a substrate ablation approach will be performed. 7. PVS is repeatedly attempting to reinduce VT after completing; 8. Endpoint: non-inducibility of any VT.

DRUG

Antiarrhythmic Drug Therapy (amiodarone, sotalol, or mexiletine)

The patients with a positive NIPS already on antiarrhythmic drugs (AAD) before the index procedure will re-start the original antiarrhythmic therapy. Patients who were not on AAD will start a new drug at the operator's discretion (amiodarone, sotalol, or mexiletine) according to clinical practice.

Trial Locations (1)

20132

San Raffaele Hospital, Arrhythmology and Electrophysiology unit, Milan

All Listed Sponsors
lead

IRCCS Ospedale San Raffaele

OTHER

NCT06669299 - Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies | Biotech Hunter | Biotech Hunter