NCT06669026View on ClinicalTrials.gov

The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic

PHASE2CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

September 1, 2023

Primary Completion Date

March 15, 2024

Study Completion Date

September 20, 2024

Conditions
Periodontal Pocket
Interventions
DIETARY_SUPPLEMENT

vitamin D loaded Poly lactic-co-glycolic acid nanoparticles gel

Scaling and root debridement then inject gel in the pocket

DIETARY_SUPPLEMENT

vitamin D3 gel (regular non-nanoparticle form)

Scaling and root debridement then inject gel in the pocket

OTHER

Poly lactic-co-glycolic acid nanoparticles placebo gel

Scaling and root debridement then inject gel in the pocket

PROCEDURE

only mechanical debridement

Scaling and root debridement

Trial Locations (1)

11851

Alaaeldin Ahmed Taha, Cairo

All Listed Sponsors
lead

Mansoura University

OTHER

NCT06669026 - The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic | Biotech Hunter | Biotech Hunter