Time Required to Dissolve Urate Deposits

Not yet recruitingOBSERVATIONAL
Enrollment

250

Participants

Timeline

Start Date

November 30, 2024

Primary Completion Date

November 30, 2032

Study Completion Date

November 30, 2032

Conditions
Gout
Interventions
DIAGNOSTIC_TEST

Standard X-Rays

\- Standard X-Rays: feet (Month 0)

DIAGNOSTIC_TEST

Ultrasound

\- Ultrasound (score 0-24): assessment for DC (Double Contour) sign (0-3), aggregates (0-3), tophi (0-3) at MTP1s (first metatarsophalangeal joints) and DC sign (0-3) at both knees, according to the OMERACT, every 6 months until complete dissolution of urate deposits.

DIAGNOSTIC_TEST

DECT of feet

DECT of feet: in tophaceous patients only (Month 0, Month 24)

BIOLOGICAL

DNA sample

DNA will be collected at Month 0

BIOLOGICAL

Serum collection

\- Serum will be collected at Month 0, Month 6, Month 12, Month 18, Month 24 , Month 36 and Month 48. For OMICs and epigenetic studies: Month 0, Month 6, Month 24 and Month 36.

Trial Locations (1)

75010

APHP, Lariboisière Hospital, Rheumatology departement, Paris

All Listed Sponsors
collaborator

Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

collaborator

ART VIGGO Association for Research

UNKNOWN

lead

Assistance Publique - Hôpitaux de Paris

OTHER

NCT06669000 - Time Required to Dissolve Urate Deposits | Biotech Hunter | Biotech Hunter