Does Co-administration of Lactate Affect Postprandial Nutrient Absorption and Fat Disposition?

NARecruitingINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

August 22, 2024

Primary Completion Date

January 31, 2026

Study Completion Date

January 31, 2026

Conditions
Pre DiabetesMetabolic Syndrome
Interventions
COMBINATION_PRODUCT

Placebo + mixed meal

Placebo (140 mL isoosmotic salt water, NaCl) given 30 minutes before a liquid test meal with the addition of 70 MBq 18F-FTHA = CTR

COMBINATION_PRODUCT

Lactate + mixed meal

Lactate (140 mL lactate drink = 25 g D/L-lactate bound to Na) given 30 minutes before a liquid test meal with the addition of 70 MBq 18F-FTHA = LAC The investigators will also use the 18F-FTHA standardized uptake value (SUV) to evaluate dietary fatty acid trapping and distribution, to be able to compare our results with former studies using the 18F-FTHA method.

RADIATION

PET-scan

Dynamic whole-body PET scan.

COMBINATION_PRODUCT

Mixed meal with 18F-FTHA

Mixed meal test with the addition of 70 MBq 18F-FTHA

Trial Locations (1)

8200

RECRUITING

Aarhus University Hospital, Aarhus

All Listed Sponsors
lead

University of Aarhus

OTHER