Minimally Invasive Surgery and RhTNK-tPA for Intracerebral Hemorrhage Evacuation

PHASE1CompletedINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

November 4, 2024

Primary Completion Date

January 27, 2025

Study Completion Date

January 27, 2025

Conditions
Intracranial HemorrhagesCerebrovascular DisordersCerebral HemorrhageHemorrhage
Interventions
DRUG

Minimally invasive surgery plus low-dose rhTNK-tPA group

The calculated injection amount of teneplase (teneplase injection amount = volume of hematoma ×0.001mg) was diluted to 1ml with sterile injection water, and injected into the stereotaxically planned puncture path according to the location and size of the hematoma. The pipeline was rinsed with 0.5ml normal saline, and the drainage tube was fixed and closed for 2 hours, so that after the full effect of the drug on the hematoma mass was ensured. Re-open the drain to allow gravity drainage.

DRUG

Minimally invasive surgery plus medium dose rhTNK-tPA group

The calculated injection amount of teneplase (teneplase injection amount = volume of hematoma ×0.003mg) was diluted to 1ml with sterile injection water, and injected into the stereotaxically planned puncture path according to the location and size of the hematoma. The pipeline was rinsed with 0.5ml normal saline, and the drainage tube was fixed and closed for 2 hours, so that after the full effect of the drug on the hematoma mass was ensured. Re-open the drain to allow gravity drainage.

DRUG

Minimally invasive surgery plus high dose rhTNK-tPA group

The calculated injection amount of teneplase (teneplase injection amount = volume of hematoma ×0.009mg) was diluted to 1ml with sterile injection water, and injected into the stereotaxically planned puncture path according to the location and size of the hematoma. The pipeline was rinsed with 0.5ml normal saline, and the drainage tube was fixed and closed for 2 hours, so that after the full effect of the drug on the hematoma mass was ensured. Re-open the drain to allow gravity drainage.

Trial Locations (1)

100730

: Beijing Tongren Hospital, Capital Medical University,, Beijing

All Listed Sponsors
lead

Beijing Tiantan Hospital

OTHER

NCT06668441 - Minimally Invasive Surgery and RhTNK-tPA for Intracerebral Hemorrhage Evacuation | Biotech Hunter | Biotech Hunter