A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

PHASE3RecruitingINTERVENTIONAL
Enrollment

3,082

Participants

Timeline

Start Date

December 2, 2024

Primary Completion Date

January 26, 2031

Study Completion Date

January 26, 2031

Conditions
Coronavirus Disease (COVID-19)
Interventions
DRUG

Molnupiravir

Molnupiravir administered orally as two 400 mg film-coated tablets every 12 hours for 5 days (a total of 10 consecutive doses)

DRUG

Placebo

Molnupiravir-matching placebo administered orally as two film-coated tablets every 12 hours for 5 days (a total of 10 consecutive doses)

Trial Locations (201)

114

RECRUITING

Tri-Service General Hospital ( Site 3304), Taipei

333

RECRUITING

Chang Gung Memorial Hospital - Linkou Branch ( Site 3303), Taoyuan District

807

RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 3306), Kaoshiung

813

RECRUITING

Kaohsiung Veterans General Hospital ( Site 3307), Kaohsiung City

1010

RECRUITING

Optimal Clinical Trials ( Site 2306), Auckland

1113

RECRUITING

Diagnostic Consultative Center 22 - Sofia ( Site 0500), Sofia

1510

RECRUITING

Medical Center Hera EOOD ( Site 0505), Sofia

1708

RECRUITING

Nefra Medical Care - Moron ( Site 0109), Morón

3200

RECRUITING

Lakeland Clinical Trials Waikato ( Site 2302), Nawton

3320

RECRUITING

Medical Center Zdrave 1 ( Site 0509), Kozloduy

3400

RECRUITING

Medical Center Hera ( Site 0507), Montana

3403

RECRUITING

"MHAT Dr. Stamen Iliev Montana-Department of Pulmonology ( Site 0504)", Montana

4023

RECRUITING

DKC V - Plovdiv ( Site 0508), Plovdiv

4600

RECRUITING

Medical Center Asclepius ( Site 0506), Velingrad

5018

RECRUITING

Lakeland Clinical Trials Wellington ( Site 2303), Upper Hutt

5500

RECRUITING

Medconsult Pleven - Lovech ( Site 0501), Lovech

5800

RECRUITING

Medconsult Pleven ( Site 0503), Pleven

6000

RECRUITING

Clinic Health - Batumi ( Site 1405), Batumi

RECRUITING

Family Medical Regional Center ( Site 1404), Batumi

6010

RECRUITING

LTD High Technology Hospital Medcenter ( Site 1408), Batumi

RECRUITING

University Clinic of Innovative Medicine ( Site 1400), Batumi

7002

RECRUITING

SHATPPD Dr. Dimitar Gramatikov - Ruse EOOD ( Site 0502), Rousse

7011

RECRUITING

Pacific Clinical Research Network - Tasman ( Site 2304), Nelson

8013

RECRUITING

CGM Research Trust ( Site 2307), Christchurch

10002

RECRUITING

National Taiwan University Hospital ( Site 3301), Taipei

10065

RECRUITING

Weill Cornell Medical College ( Site 3814), New York

10117

RECRUITING

Campus Charite Mitte Nephrologie und Internistische Intensivmedizin ( Site 1501), Berlin

10330

RECRUITING

HIV Netherlands Australia Thailand Research Collaboration ( Site 3402), Pathumwan

10456

RECRUITING

Prime Global Research ( Site 3731), The Bronx

10700

RECRUITING

Faculty of Medicine Siriraj Hospital-Department of Medicine ( Site 3401), Bangkok

14080

RECRUITING

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran-Departamento de Infectología ( Site 2203), Mexico City

15036

RECRUITING

Clinica Ricardo Palma-Centro de Investigacion de Enfermedades Respiratorias Thorax ( Site 2404), Lima

15355

RECRUITING

Korea University Ansan Hospital ( Site 3007), Ansan-si

16001

RECRUITING

Asociación Civil Selva Amazónica ( Site 2405), Iquitos

16132

RECRUITING

Ospedale San Martino ( Site 1900), Genova

18021

RECRUITING

EUROMEDCLINIC ( Site 3517), Cherkasy

20157

RECRUITING

ASST Fatebenefratelli Sacco ( Site 1901), Milan

21000

RECRUITING

Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital F-Centre d'Investigation Clinique - Plur ( Site 1301), Dijon

21001

RECRUITING

University clinic of the National Pirogov Memorial Medical University ( Site 3547), Vinnytsia

21045

RECRUITING

Kur Research - Columbia Medical ( Site 3767), Columbia

21401

RECRUITING

Annapolis Internal Medicine - CCT Research ( Site 3700), Annapolis

23666

RECRUITING

Velocity Clinical Research - Hampton ( Site 3744), Hampton

25006

RECRUITING

Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 3537), Kropyvnytskyi

25011

RECRUITING

Limited Liability Company Ukrainian Center of Tomotherapy-Clinical Trials Department ( Site 3512), Kropyvnytskyi

26426

RECRUITING

Wonju Severance Christian Hospital-Internal Medicine ( Site 3009), Wŏnju

27030

RECRUITING

IMA Clinical Research Mount Airy ( Site 3745), Mount Airy

28031

RECRUITING

Hospital Universitario Infanta Leonor ( Site 3110), Madrid

28112

RECRUITING

Monroe Biomedical Research ( Site 3732), Monroe

28277

RECRUITING

OnSite Clinical Solutions ( Site 3784), Charlotte

29205

RECRUITING

Midlands Neurology & Pain Associates ( Site 3751), Columbia

30046

RECRUITING

Balanced Life Health Care Solutions/SKYCRNG ( Site 3713), Lawrenceville

30078

RECRUITING

Renew Health Clinical Research ( Site 3760), Snellville

30202

RECRUITING

Hospital Santa Lucia-Medicina Infecciosas ( Site 3106), Cartagena

30291

RECRUITING

Rophe Adult and Pediatric Medicine/SKYCRNG ( Site 3816), Union City

31000

RECRUITING

ICARO Investigaciones en Medicina ( Site 2200), Chihuahua City

32807

RECRUITING

Combined Research Orlando Phase I-IV ( Site 3797), Orlando

33004

RECRUITING

Taoyuan General Hospital ( Site 3300), Taoyuan

33012

RECRUITING

Indago Research & Health Center, Inc ( Site 3714), Hialeah

33014

RECRUITING

Palm Springs Community Health Center ( Site 3757), Miami Lakes

RECRUITING

Panax Clinical Research ( Site 3803), Miami Lakes

33030

RECRUITING

Prestige Clinical Research ( Site 3830), Homestead

33125

RECRUITING

Southern Clinical Research ( Site 3773), Miami

33134

RECRUITING

Prestige Clinical Research Center ( Site 3722), Coral Gables

33143

RECRUITING

Florida Pharmaceutical Research and Associates ( Site 3763), Miami

33144

RECRUITING

Bio-Medical Research LLC ( Site 3804), Miami

COMPLETED

Bright Research Center ( Site 3746), Miami

33155

RECRUITING

Miami Clinical Research ( Site 3729), Miami

33176

RECRUITING

Reed Medical Research ( Site 3761), Miami

33331

RECRUITING

Encore Medical Research - Weston ( Site 3708), Weston

33436

RECRUITING

Encore Medical Research of Boynton Beach ( Site 3701), Boynton Beach

33470

RECRUITING

Advanced Pulmonary Research Institute ( Site 3781), Loxahatchee Groves

33603

RECRUITING

New Tampa Health ( Site 3764), Tampa

33607

RECRUITING

Clinical Research Trials of Florida ( Site 3703), Tampa

33614

RECRUITING

Precision Research Center ( Site 3704), Tampa

33777

RECRUITING

Accel Research Sites Network - St. Pete-Largo Clinical Research Unit ( Site 3779), Largo

34748

RECRUITING

Clinical Site Partners, LLC dba Flourish Research ( Site 3717), Leesburg

34952

RECRUITING

CDC Research Institute ( Site 3716), Port Saint Lucie

35055

RECRUITING

Cullman Clinical Trials ( Site 3813), Cullman

37000

RECRUITING

Morales Vargas Centro de Investigacion ( Site 2206), León

38305

RECRUITING

Helios Clinical Research - JAC ( Site 3833), Jackson

39069

RECRUITING

Prime Health and Wellness/SKYCRNG ( Site 3726), Fayette

39157

RECRUITING

SKY Integrative Medical Center/SKYCRNG ( Site 3740), Ridgeland

40138

RECRUITING

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1904), Bologna

40202

RECRUITING

University of Louisville School of Medicine ( Site 3706), Louisville

40705

RECRUITING

Taichung Veterans General Hospital ( Site 3305), Taichung

41013

RECRUITING

HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO ( Site 3100), Seville

41404

RECRUITING

Kyungpook National University Chilgok Hospital-Division of Infectious Diseases ( Site 3002), Deagu

42270

RECRUITING

CHU de Saint-Etienne ( Site 1302), Saint Priest En Jarez

43005

RECRUITING

"Municipal Enterprise Volyn Regional Clinical Hospital of Volyn Regional Council ( Site 3530)", Lutsk

44630

RECRUITING

CIO - Centro de Inmuno-Oncología de Occidente ( Site 2207), Guadalajara

45431

RECRUITING

Research Innovations, LLC ( Site 3712), Beavercreek

48126

RECRUITING

Revival Research Institute, LLC ( Site 3835), Dearborn

48236

RECRUITING

Henry Ford St John TM Center for Infectious Disease Research ( Site 3766), Grosse Pointe Woods

48334

RECRUITING

Michigan Center of Medical Research (MICHMER) ( Site 3734), Farmington Hills

49241

RECRUITING

Pusan National University Hospital-Internal Medicine ( Site 3010), Pusan

50016

RECRUITING

IPS SURA San Diego ( Site 0806), Medellín

50937

RECRUITING

Universitaetsklinikum Koeln ( Site 1505), Cologne

52727

RECRUITING

Gyeongsang National University Hospital ( Site 3005), Jinju

56001

RECRUITING

Mankato Clinic ( Site 3842), Mankato

56124

RECRUITING

AOU Pisana- Ospedale Cisanello ( Site 1905), Pisa

58022

RECRUITING

MUNICIPAL NON-PROFIT ENTERPRISE CENTRAL CITY CLINICAL HOSPITAL OF CHERNIVTSI CITY COUNCIL ( Site 3513), Chernivtsi

60590

RECRUITING

Universitätsklinikum Frankfurt Goethe-Universität ( Site 1503), Frankfurt am Main

61469

RECRUITING

Chonnam National University Hospital-Infectious Diseases ( Site 3008), Gwangju

64460

RECRUITING

"Hospital Universitario Dr. Jose Eleuterio Gonzalez-Infectologia ( Site 2204)", Monterrey

69310

RECRUITING

centre hospitalier lyon sud ( Site 1303), Pierre-Bénite

71457

ACTIVE_NOT_RECRUITING

Barnum Medical Research ( Site 3828), Natchitoches

75013

RECRUITING

Pitie Salpetriere University Hospital-Infectious Disease - Tropical Diseases ( Site 1300), Paris

75126

RECRUITING

Care United Research, LLC ( Site 3747), Forney

76008

RECRUITING

"Clinical medical and diagnostic center Limited Liability Company Simedgroup ( Site 3524)", Ivano-Frankivsk

76018

RECRUITING

Regional Phthisiology and Pulmonology Center ( Site 3523), Ivano-Frankivsk

77030

RECRUITING

Houston Methodist Hospital ( Site 3800), Houston

77384

RECRUITING

Javara - Privia Medical Group Gulf Coast - The Woodlands HWH ( Site 3837), Conroe

77584

RECRUITING

LinQ Research ( Site 3824), Pearland

77901

RECRUITING

Crossroads Clinical Research-Family Practice ( Site 3739), Victoria

78041

RECRUITING

Andres Garcia Zuniga, M.D., P.A. ( Site 3782), Laredo

78404

RECRUITING

South Texas Clinical Research ( Site 3815), Corpus Christi

79011

RECRUITING

Polyclinic of Communal 4th city clinical hospital ( Site 3501), Lviv

79059

RECRUITING

"Municipal non-profit enterprise Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 3525)", Lviv

80033

RECRUITING

Paradigm Clinical Research Centers, Inc ( Site 3718), Wheat Ridge

81675

RECRUITING

TUM Klinikum ( Site 1502), Munich

83709

RECRUITING

Paradigm Clinical Research - Boise ( Site 3841), Boise

85051

RECRUITING

Absolute Clinical Research ( Site 3709), Phoenix

85253

RECRUITING

Helios Clinical Research ( Site 3826), Paradise Valley

88000

RECRUITING

Uzhhorod Municipal Multidisciplinary Clinical Hospital of Uzhhorod City Council ( Site 3538), Uzhhorod

89106

RECRUITING

WR-CRCN, LLC ( Site 3818), Las Vegas

89706

RECRUITING

Nevada Health Centers ( Site 3840), Carson City

90720

RECRUITING

Pacific Clinical Studies ( Site 3827), Los Alamitos

91208

RECRUITING

Paradigm Clinical Research, LLC ( Site 3785), San Diego

91325

RECRUITING

Valley Clinical Trials, Inc. ( Site 3707), Northridge

91361

RECRUITING

Millennium Clinical Trials ( Site 3758), Westlake Village

91910

RECRUITING

Arké SMO S.A de C.V-ARKE SMO S.A. de C.V. ( Site 2210), Veracruz

92835

RECRUITING

Ascada Health PC dba Ascada Research ( Site 3750), Fullerton

93030

RECRUITING

FOMAT Medical Research ( Site 3720), Oxnard

94102

RECRUITING

Optimus Medical ( Site 3817), San Francisco

95012

RECRUITING

Clinica de Salud del Valle de Salinas ( Site 3825), Castroville

98052

RECRUITING

Eastside Research Associates ( Site 3727), Redmond

110121

RECRUITING

Clinica Colsanitas - Sede Reina Sofia ( Site 0807), Bogotá

111321

RECRUITING

Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 0804), Bogotá

200001

RECRUITING

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0801), Valledupar

230002

RECRUITING

IMAT S.A.S ( Site 0805), Montería

400348

RECRUITING

Spitalul Clinic de Boli Infecțioase ( Site 2703), Cluj-Napoca

760032

RECRUITING

Fundación Valle del Lili ( Site 0803), Santiago de Cali

900709

RECRUITING

Spitalul Clinic de Boli Infecțioase ( Site 2702), Constanța

07102

RECRUITING

Saint Michael's Medical Center ( Site 3808), Newark

07666

RECRUITING

Holy Name Medical Center ( Site 3807), Teaneck

C1431FWO

RECRUITING

CEMIC ( Site 0101), Buenos Aires.

C1199ABB

RECRUITING

Hospital Italiano de Buenos Aires ( Site 0107), Ciudad Autonoma de Buenos Aires.

B7600FZO

RECRUITING

Instituto de Investigaciones Clinicas Mar del Plata ( Site 0111), Mar del Plata

30180-080

RECRUITING

Hospital Felicio Rocho (HFR) - Nucleo de Ciencias da Saude ( Site 0402), Belo Horizonte

13060-803

RECRUITING

Centro de Pesquisa Sao Lucas ( Site 0401), Campinas

05403-010

RECRUITING

Centro de Pesquisa Clinica II - ICHC - FMUSP ( Site 0403), São Paulo

080020

RECRUITING

IPS Centro Científico Asistencial S.A.S ( Site 0800), Barranquilla

00290

RECRUITING

MeVac - Meilahti Vaccine Research Center ( Site 1200), Helsinki

0186

RECRUITING

Caucasus Medical Centre ( Site 1406), Tbilisi

RECRUITING

Curatio Clinic - Main Location ( Site 1401), Tbilisi

284-0003

RECRUITING

National Hospital Organization Shimoshizu National Hospital ( Site 2007), Yotsukaidō

300-0062

RECRUITING

Tsuchiura Beryl Clinic ( Site 2009), Tsuchiura

204-8585

RECRUITING

National Hospital Organization Tokyo National Hospital ( Site 2003), Kiyose

171-0014

RECRUITING

Sekino Hospital ( Site 2016), Toshimaku

810-8563

RECRUITING

National Hospital Organization Kyushu Medical Center ( Site 2006), Fukuoka

862-0965

RECRUITING

Kumamoto Chuo Hospital ( Site 2002), Kumamoto

0600

RECRUITING

Pacific Clinical Research Network West Auckland ( Site 2301), Auckland

0632

RECRUITING

Optimal Clinical Trials North ( Site 2308), Auckland

0932

RECRUITING

Silverdale Medical Limited ( Site 2305), Auckland

60-309

RECRUITING

PL Certus ( Site 2613), Poznan

85-048

RECRUITING

In-Vivo Bydgoszcz ( Site 2601), Bydgoszcz

31-322

RECRUITING

NZOZ GynCentrum - Oddział Kraków ( Site 2609), Krakow

50-220

RECRUITING

Przychodnia EuroMediCare, Wroclaw Lowiecka ( Site 2611), Wroclaw

43-300

RECRUITING

NZOZ GynCentrum - Oddział Bielsko-Biała ( Site 2602), Bielsko-Biala

40-156

RECRUITING

Clinical Medical Research ( Site 2604), Katowice

40-600

RECRUITING

Holsamed ( Site 2603), Katowice

00791

RECRUITING

Investigadores del Este LLC ( Site 4001), Humacao

00921

RECRUITING

Miralles Clinical Research LLC ( Site 4004), San Juan

00926

RECRUITING

MV HEALTH SERVICES LLC ( Site 4003), San Juan

030303

RECRUITING

Spitalul Clinic de Boli Infecțioase și Tropicale Victor Babeș ( Site 2701), Bucharest

077015

RECRUITING

Spitalul Clinic De Urgenta Prof Dr Agrippa Ionescu ( Site 2705), Baloteşti

011025

RECRUITING

Centrul Medical SANA ( Site 2704), Bucharest

021105

RECRUITING

National Institute for Infectious Diseases Prof. Dr. Matei Bals ( Site 2706), Bucharest

02841

RECRUITING

Korea University Anam Hospital ( Site 3001), Seoul

07441

RECRUITING

Hallym University Kangnam Sacred Heart Hospital-Internal Medicine ( Site 3003), Seoul

08308

RECRUITING

Korea University Guro Hospital ( Site 3006), Seoul

03202

RECRUITING

Hospital General Universitario de Elche-Infectius Disease ( Site 3105), Elche

08916

RECRUITING

Hospital Germans Trias i Pujol ( Site 3101), Badalona

08540

RECRUITING

EAP Osona Sud - Alt Congost S.L.P ( Site 3107), Centelles

08035

RECRUITING

Hospital Universitari Vall d'Hebron ( Site 3102), Barcelona

08025

RECRUITING

EAP Sardenya ( Site 3109), Barcelona

01135

RECRUITING

"Medical Center Harmoniya Krasy ( Site 3545)", Kyiv

02002

RECRUITING

Edelweiss Medics ( Site 3503), Kyiv

02091

RECRUITING

"Communal Non-Profit Enterprise Kyiv City Clinical Hospital #1-Department of Clinical Research ( Site 3514)", Kyiv

03037

RECRUITING

Medbud Clinic-Treatment prevention unit ( Site 3506), Kyiv

04050

RECRUITING

Medical Center of Limited ( Site 3546), Kyiv

04210

RECRUITING

Center of Family Medicine Plus ( Site 3502), Kyiv

02222

RECRUITING

Medlight Clinic ( Site 3548), Kyiv

03049

RECRUITING

Kyiv Railway Clinical Hospital No.2 of Branch Health Center -Center of Clinical Trials ( Site 3549), Kyiv

BS8 2PU

RECRUITING

Whiteladies Medical Group ( Site 3611), Bristol

EX2 5DW

RECRUITING

Royal Devon & Exeter Hospital ( Site 3604), Exeter

NE1 4LP

RECRUITING

Royal Victoria Infirmary ( Site 3608), Newcastle

NR3 3DL

RECRUITING

Oak Street Medical Practice ( Site 3612), Norwich

NN17 2UR

RECRUITING

Lakeside Surgery ( Site 3600), Northamptonshire

OX26 6AT

RECRUITING

Bicester Health Centre ( Site 3609), Bicester

OX16 9AD

RECRUITING

Banbury Cross Health Centre ( Site 3610), Oxford

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY