A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

PHASE2RecruitingINTERVENTIONAL
Enrollment

480

Participants

Timeline

Start Date

December 16, 2024

Primary Completion Date

May 23, 2029

Study Completion Date

December 26, 2030

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG

Amivantamab

Amivantamab will be administered.

DRUG

Lazertinib

Lazertinib tablet will be administered.

DRUG

Chemotherapy: Pemetrexed

Pemetrexed will be administered.

DRUG

Chemotherapy: Carboplatin

Carboplatin will be administered.

Trial Locations (143)

10016

RECRUITING

NYU Langone Health Laura and Isaac Perlmutter Cancer Center, New York

10032

RECRUITING

Herbert Irving Comprehensive Cancer Center Columbia University Medical Center, New York

10461

RECRUITING

Montefiore Medical Center, The Bronx

11501

RECRUITING

Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island, Mineola

11590

RECRUITING

Clinical Research Alliance Inc, Westbury

11967

RECRUITING

New York Cancer and Blood Specialists, Shirley

12308

RECRUITING

Ellis Hospital, Schenectady

13057

RECRUITING

Hematology-Oncology Associates of CNY, East Syracuse

19010

RECRUITING

Lankenau Institute for Medical Research Main Line Health Bryn Mawr Hospital, Bryn Mawr

19096

RECRUITING

Lankenau Institute for Medical Research, Wynnewood

19104

RECRUITING

Philadelphia VA Medical Center, Philadelphia

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

19114

RECRUITING

Jefferson Health Northeast, Philadelphia

19301

RECRUITING

Lankenau Institute for Medical Research Main Line Health Paoli Hospital, Paoli

19611

RECRUITING

McGlinn Cancer Institute Reading Hospital, West Reading

19713

RECRUITING

ChristianaCare Helen F Graham Cancer Center and Research Institute, Newark

20007

RECRUITING

MedStar Georgetown University Hospital, Washington D.C.

20422

RECRUITING

Washington DC VA Medical Center, Washington D.C.

20904

RECRUITING

Maryland Oncology Hematology P A, Silver Spring

21201

RECRUITING

University of Maryland, Baltimore

22031

RECRUITING

Virginia Cancer Specialists, Fairfax

27893

RECRUITING

Regional Medical Oncology Center, Wilson

28204

RECRUITING

Atrium Health, Charlotte

30265

RECRUITING

City of Hope Cancer Center, Newnan

30303

RECRUITING

Grady Health System Correll Pavilion, Atlanta

30309

RECRUITING

Piedmont Healthcare, Atlanta

30318

RECRUITING

Piedmont Cancer Institute, Atlanta

30322

RECRUITING

Winship Cancer Institute Emory University, Atlanta

30607

RECRUITING

University Cancer And Blood Center LLC, Athens

32207

RECRUITING

Baptist MD Anderson Cancer Center, Jacksonville

32224

RECRUITING

Mayo Clinic, Jacksonville

32608

RECRUITING

Univ of Florida, Gainesville

32803

RECRUITING

AdventHealth Orlando, Orlando

32806

RECRUITING

Orlando Health Cancer Institute, Orlando

33176

RECRUITING

Baptist Health Miami Cancer Institute, Miami

33316

RECRUITING

The Oncology Institute of Hope and Innovation, Fort Lauderdale

33401

RECRUITING

Florida Cancer Specialists & Research Institute, West Palm Beach

33486

RECRUITING

Baptist Lynn Cancer Institute, Boca Raton

33612

RECRUITING

Moffitt Cancer Center, Tampa

33705

RECRUITING

Florida Cancer Specialists & Research Institute, St. Petersburg

33916

RECRUITING

Florida Cancer Specialists, Fort Myers

35805

RECRUITING

Clearview Cancer Institute, Huntsville

36526

RECRUITING

Southern Cancer Center, PC, Daphne

37203

RECRUITING

SCRI Oncology Partners, Nashville

RECRUITING

Tennessee Oncology, Nashville

37404

RECRUITING

Tennessee Oncology, Chattanooga

37909

RECRUITING

Tennessee Cancer Specialists, Knoxville

37920

RECRUITING

University of Tennessee, Knoxville

38120

RECRUITING

Baptist Cancer Center, Memphis

39202

RECRUITING

Jackson Oncology Associates, Jackson

45219

RECRUITING

University of Cincinnati, Cincinnati

46062

RECRUITING

Investigative Clinical Research of Indiana, LLC, Noblesville

46804

RECRUITING

Fort Wayne Medical Oncology and Hematology, Fort Wayne

48105

RECRUITING

University of Michigan Health System, Ann Arbor

48197

RECRUITING

Trinity Health St Joseph Mercy Ann Arbor, Ypsilanti

50010

RECRUITING

Accellacare of McFarland, Ames

55455

RECRUITING

University Of Minnesota, Minneapolis

55905

RECRUITING

Mayo Clinic Rochester, Rochester

57105

RECRUITING

Avera Medical Group, Sioux Falls

60099

RECRUITING

City of Hope Chicago, Zion

60521

RECRUITING

Hope and Healing Cancer Services, Hinsdale

60612

RECRUITING

University of Illinois at Chicago, Chicago

60714

RECRUITING

Illinois Cancer Specialists, Niles

62526

RECRUITING

Cancer Care Specialists of Central Illinois, Decatur

63110

RECRUITING

Washington University School Of Medicine, St Louis

64108

RECRUITING

Truman Medical Ctr West, Kansas City

65807

RECRUITING

Oncology Hematology Associates, Springfield

66205

RECRUITING

University of Kansas Cancer Center, Fairway

75235

RECRUITING

Parkland Health and Hospital System, Dallas

75246

RECRUITING

Texas Oncology DFW, Dallas

75390

RECRUITING

UT Southwestern Medical Center, Dallas

75701

RECRUITING

The University of Texas Health Science Center at Tyler, Tyler

75702

RECRUITING

Texas Oncology - Northeast, Tyler

76104

RECRUITING

JPS Health Network, Fort Worth

77030

RECRUITING

MD Anderson Cancer Center, Houston

RECRUITING

Oncology Consultants Texas, Houston

77339

RECRUITING

Community Clinical Trials, Kingwood

77380

RECRUITING

Renovatio Clinical, The Woodlands

77598

RECRUITING

Texas Oncology-Gulf Coast, Webster

78217

RECRUITING

Texas Oncology San Antonio Northeast, San Antonio

78745

RECRUITING

Texas Oncology South, Austin

79761

RECRUITING

Texas Oncology Odessa-West Texas Cancer Center, Odessa

79915

RECRUITING

Renovatio Clinical, El Paso

80124

RECRUITING

Rocky Mountain Cancer Centers, Lone Tree

80206

RECRUITING

National Jewish Health, Denver

80218

RECRUITING

Saint Josephs Hospital Cancer Centers of Colorado, Denver

80401

RECRUITING

Lutheran Hospital Cancer Centers of Colorado, Golden

84112

RECRUITING

Huntsman Cancer Institute, Salt Lake City

85338

RECRUITING

City of Hope Phoenix, Goodyear

87102

RECRUITING

University of New Mexico, Albuquerque

90015

RECRUITING

The Oncology Institute of Hope and Innovation, Glendale

90033

RECRUITING

USC Norris Comprehensive Cancer Center, Los Angeles

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

90067

RECRUITING

Valkyrie Clinical Trials, Los Angeles

90720

RECRUITING

Cancer and Blood Specialty Clinic, Los Alamitos

90813

RECRUITING

City of Hope Long Beach Elm, Long Beach

91010

RECRUITING

City of Hope, Duarte

91030

RECRUITING

City of Hope South Pasadena, South Pasadena

91203

RECRUITING

Oncology Physicians Network Healthcare, Glendale

91204

RECRUITING

Los Angeles Cancer Network, Glendale

91206

RECRUITING

Glendale Adventist Medical Center, Glendale

91786

RECRUITING

City of Hope Upland, Upland

92093

RECRUITING

University of California San Diego Health, La Jolla

92562

RECRUITING

Valkyrie Clinical Trials, Murrieta

92618

RECRUITING

City of Hope Orange County Lennar Foundation Cancer Center, Irvine

92648

RECRUITING

City of Hope Seacliff, Huntington Beach

92835

RECRUITING

Providence Medical Foundation, Fullerton

92868

RECRUITING

St. Joseph Hospital Center for Cancer Prevention and Treatment, Orange

RECRUITING

University of California Irvine, Orange

92882

RECRUITING

City of Hope Corona, Corona

93105

RECRUITING

Sansum Clinic, Santa Barbara

93534

RECRUITING

City of Hope Antelope Valley, Lancaster

94115

RECRUITING

California Pacific Medical Center, San Francisco

RECRUITING

Kaiser Permanente San Francisco Medical Center, San Francisco

94143

RECRUITING

UCSF Zuckerberg San Francisco General Hospital, San Francisco

94301

RECRUITING

Sutter Health Palo Alto Medical Foundation, Palo Alto

94589

RECRUITING

Kaiser Permanente Northern California, Vallejo

94596

RECRUITING

Kaiser Permanente Walnut Creek Medical Center, Walnut Creek

94598

RECRUITING

John Muir Health Clinical Research Center, Walnut Creek

94611

RECRUITING

Kaiser Permanente Oakland Medical Center, Oakland

94904

RECRUITING

Marin Cancer Center, Greenbrae

95051

RECRUITING

Kaiser Permanente Santa Clara Medical Center, Santa Clara

95403

RECRUITING

Providence Medical Foundation, Santa Rosa

95630

RECRUITING

UC Davis Comprehensive Cancer Center, Sacramento

95661

RECRUITING

Kaiser Permanente Roseville Medical Center, Roseville

95816

RECRUITING

Sutter Institute for Medical Research, Sacramento

97239

RECRUITING

Oregon Health And Science University, Portland

97401

RECRUITING

Oncology Associates of Oregon PC Willamette Valley Cancer Institute, Eugene

98506

RECRUITING

Vista Oncology, Olympia

98684

RECRUITING

Northwest Cancer Specialists - Vancouver, Vancouver

99208

RECRUITING

Summit Cancer Centers, Spokane

5262000

RECRUITING

Sheba Medical Center, Ramat Gan

06520

RECRUITING

Yale New Haven Hospital Yale Cancer Center, New Haven

02118

RECRUITING

Boston University Medical Center, Boston

02215

RECRUITING

Beth Israel Deaconess Medical Center, Boston

RECRUITING

Dana Farber Cancer Institute, Boston

03756

RECRUITING

Dartmouth Hitchcock Medical Center, Lebanon

08822

RECRUITING

Hunterdon Hematology Oncology, Flemington

07960

RECRUITING

Morristown Medical Center, Morristown

08901

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

07901

RECRUITING

Overlook Medical Center, Summit

07666

RECRUITING

Holy Name Medical Center, Teaneck

00918

RECRUITING

Auxilio Mutuo Cancer Center, San Juan

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY