A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) (MK-7962-024)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

November 14, 2024

Primary Completion Date

November 20, 2025

Study Completion Date

November 20, 2025

Conditions
Pulmonary Arterial Hypertension
Interventions
BIOLOGICAL

Sotatercept

SC administered every 3 weeks.

BIOLOGICAL

Background PAH Therapy

Background PAH therapy may consist of the following drug classes: single, double, or triple combination of therapy with endothelin-receptor antagonists, phosphodiesterase inhibitors, soluble guanylate cyclase stimulators, and/or prostacyclin analogs or receptor antagonists

Trial Locations (98)

1083

Semmelweis Egyetem ( Site 0701), Budapest

1096

Gottsegen Gyorgy Orszagos Kardiologiai Intezet ( Site 0702), Budapest

2050

Royal Prince Alfred Hospital ( Site 0103), Camperdown

2145

Westmead Hospital ( Site 0100), Westmead

3000

Hospital Provincial Jose Maria Cullen ( Site 0005), Santa Fe

3004

The Alfred Hospital ( Site 0102), Melbourne

4066

Wesley Research Institute ( Site 0101), Auchenflower

6725

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ ( Site 0704), Szeged

7624

Pécsi Tudományegyetem Klinikai Központ ( Site 0703), Pécs

10117

Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0609), Berlin

10126

A.O.U. Citta della Salute e della Scienza di Torino ( Site 0904), Turin

10700

Faculty of Medicine Siriraj Hospital ( Site 1600), Bangkok

11217

Taipei Veterans General Hospital ( Site 1502), Taipei

13015

Assistance Publique Hôpitaux de Marseille - Hôpital Nord ( Site 0500), Marseille

16132

Ospedale San Martino ( Site 0901), Genoa

20122

Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico ( Site 0902), Milan

20162

ASST Grande Ospedale Metropolitano Niguarda ( Site 0900), Milan

20246

Universitaetsklinikum Hamburg-Eppendorf ( Site 0610), Hamburg

20900

Fondazione IRCCS San Gerardo dei Tintori ( Site 0911), Monza

21079

CHU Dijon Bourgogne ( Site 0502), Dijon

27100

Fondazione IRCCS Policlinico San Matteo ( Site 0909), Pavia

28034

Hospital Ramon y Cajal ( Site 1401), Madrid

28041

Hospital General Universitario 12 de Octubre ( Site 1403), Madrid

28046

Hospital Universitario La Paz ( Site 1410), Madrid

30625

Medizinische Hochschule Hannover ( Site 0604), Hanover

33604

CHU Bordeaux Haut-Leveque ( Site 0501), Pessac

37126

Azienda Ospedaliera Universitaria Integrata ( Site 0908), Verona

39008

Hospital Marques de Valdecilla ( Site 1405), Santander

40138

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 0905), Bologna

40202

Norton Pulmonary Specialists ( Site 1935), Louisville

41013

Hospital Virgen del Rocio ( Site 1407), Seville

45007

Hospital Universitario de Toledo ( Site 1408), Toledo

45219

University of Cincinnati Medical Center ( Site 1927), Cincinnati

46202

Indiana University Health Methodist Hospital ( Site 1905), Indianapolis

49241

Pusan National University Hospital ( Site 1305), Busan

50200

Maharaj Nakorn Chiang Mai Hospital ( Site 1601), Chiang Mai

53127

Universitätsklinikum Bonn ( Site 0608), Bonn

53226

Froedtert Hospital & the Medical College of Wisconsin ( Site 1934), Milwaukee

56124

Fondazione G. Monasterio ( Site 0907), Pisa

61469

Chonnam National University Hospital (CNUH) ( Site 1304), Gwangju

63003

CHU GABRIEL MONTPIED ( Site 0504), Clermont-Ferrand

66160

University of Kansas Medical Center ( Site 1928), Kansas City

69126

Thoraxklinik-Heidelberg gGmbH-Zentrum für Pulmonale Hypertonie ( Site 0600), Heidelberg

70403

National Cheng Kung University Hospital ( Site 1501), Tainan City

76000

CHU de Rouen ( Site 0503), Rouen

78705

Ascension Seton Heart Specialty Care and Transplant Center ( Site 1918), Austin

80045

University of Colorado Anschutz Medical Campus-University of Colorado Hospital Cardiac and Vascular ( Site 1930), Aurora

81377

Klinikum der Universität München Großhadern ( Site 0611), München

85032

Pulmonary Associates, PA ( Site 1903), Phoenix

87131

University of New Mexico Health Sciences Center - Department of Internal Medicine ( Site 1916), Albuquerque

110111

Clinica Colsanitas - Sede Reina Sofia ( Site 0303), Bogotá

Fundacion Santa Fe de Bogota ( Site 0302), Bogota

119074

National University Heart Centre, Singapore ( Site 1200), Singapore

169609

National Heart Centre Singapore ( Site 1201), Singapore

200433

Shanghai Pulmonary Hospital ( Site 2004), Shanghai

230002

IMAT S.A.S ( Site 0301), Montería

410011

The Second Xiangya Hospital of Central South University ( Site 2002), Changsha

510080

Guangdong Provincial People s Hospital ( Site 2000), Guangzhou

650051

Yan an Hospital of Kunming City ( Site 2011), Kunming

760036

Centro de Investigaciones Clinicas SAS ( Site 0306), Santiago de Cali

760042

Clínica Imbanaco S.A.S ( Site 0304), Santiago de Cali

813414

Kaohsiung Veterans General Hospital ( Site 1503), Kaohsiung City

3109601

Rambam Health Care Campus ( Site 0802), Haifa

3436212

Carmel Hospital ( Site 0803), Haifa

4941492

Rabin Medical Center ( Site 0805), Petah Tikva

5265601

Sheba Medical Center ( Site 0801), Ramat Gan

B1904AAW

Centro Medico Capital ( Site 0002), La Plata

B7600FZO

Instituto de Investigaciones Clinicas Mar del Plata ( Site 0006), Mar del Plata

X5800AEV

Instituto Medico Rio Cuarto ( Site 0010), Río Cuarto

C1280AEB

Hospital Britanico de Buenos Aires ( Site 0004), CABA

W3400AMZ

Instituto de Cardiologia Juana F. Cabral ( Site 0008), Corrientes

T1Y 6J4

Peter Lougheed Centre ( Site 0203), Calgary

G1V 4G5

IUCPQ ( Site 0208), Québec

050034

Clinica Cardio VID ( Site 0307), Medellín

128 08

Centrum pro plicní hypertenzi VFN II. interni klinika VFN a 1. LF UK ( Site 0400), Prague

00161

AOU Policlinico Umberto I ( Site 0910), Rome

07100

Ospedale Civile SS Annunziata ( Site 0903), Sassari

466-8560

Nagoya University Hospital ( Site 2102), Nagoya

564-8565

National Cerebral and Cardiovascular Center ( Site 2103), Suita

113-8655

The University of Tokyo Hospital ( Site 2101), Bunkyo

181-8611

Kyorin University Hospital ( Site 2100), Mitaka

812-8582

Kyushu University Hospital ( Site 2105), Fukuoka

701-1192

National Hospital Organization Okayama Medical Center ( Site 2104), Okayama

6525 GA

Radboud University Medical Center ( Site 1001), Nijmegen

3435CM

Sint Antonius Ziekenhuis ( Site 1000), Nieuwegein

31-202

Krakowski Szpital Specjalistyczny im. św. Jana Pawła II ( Site 1100), Krakow

03080

Seoul National University Hospital ( Site 1302), Seoul

03722

Severance Hospital Yonsei University Health System ( Site 1300), Seoul

05505

Asan Medical Center ( Site 1303), Seoul

06351

Samsung Medical Center ( Site 1301), Seoul

07120

Hospital Universitari Son Espases ( Site 1412), Palma

08036

Hospital Clinic de Barcelona ( Site 1406), Barcelona

08035

Hospital Vall D Hebron ( Site 1404), Barcelona

CB2 0AY

Royal Papworth Hospital ( Site 1802), Cambridge

NW3 2QG

Royal Free London NHS Foundation Trust ( Site 1803), London

SW3 6NP

Royal Brompton Hospital ( Site 1804), London

W12 OHS

Hammersmith Hospital ( Site 1801), London

G81 4DY

Golden Jubilee National Hospital ( Site 1800), Glasgow

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY