A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,000

Participants

Timeline

Start Date

October 18, 2024

Primary Completion Date

December 15, 2028

Study Completion Date

December 15, 2032

Conditions
Colorectal Neoplasms
Interventions
BIOLOGICAL

Amivantamab

Amivantamab will be administered.

BIOLOGICAL

Cetuximab

Cetuximab will be administered.

DRUG

5-fluorouracil

5-fluorouracil will be administered as chemotherapy regimen.

DRUG

Leucovorin calcium/Levoleucovorin

Leucovorin calcium/Levoleucovorin will be administered as chemotherapy regimen.

DRUG

Oxaliplatin

Oxaliplatin will be administered as chemotherapy regimen.

DRUG

Irinotecan Hydrochloride

Irinotecan hydrochloride will be administered as chemotherapy regimen.

Trial Locations (226)

333

RECRUITING

Linkou Chang Gung Memorial Hospital, Taoyuan District

704

RECRUITING

National Cheng Kung University Hospital, Tainan City

1070

RECRUITING

Institut Jules Bordet, Anderlecht

1082

RECRUITING

Semmelweis Egyetem, Budapest

2650

RECRUITING

Universitair Ziekenhuis Antwerpen, Edegem

3000

RECRUITING

Universitair Ziekenhuis Leuven, Leuven

3300

RECRUITING

Markhot Ferenc Oktatokorhaz es Rendelointezet, Eger

4000

RECRUITING

Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman, Liège

6720

RECRUITING

Szegedi Tudomanyegyetem, Szeged

7100

RECRUITING

Hopital de Jolimont, Haine Saint Paul La Louviere

7624

RECRUITING

Pecsi Tudomanyegyetem, Pécs

8500

RECRUITING

Az Groeninge, Kortrijk

9000

RECRUITING

AZ Maria Middelares, Ghent

10003

RECRUITING

Mount Sinai, New York

10009

RECRUITING

Mount Sinai West, New York

10016

RECRUITING

NYU Langone Medical Center NYU Hematology Associates, New York

10032

RECRUITING

Herbert Irving Comprehensive Cancer Center Columbia University Medical Center, New York

10043

RECRUITING

National Taiwan University Hospital, Taipei

10450

RECRUITING

Hospital Pulau Pinang, George Town

10461

RECRUITING

Montefiore Einstein Comprehensive Cancer Center, The Bronx

11501

RECRUITING

Perlmutter Cancer Center at NYU Long Island, Mineola

11967

RECRUITING

New York Cancer and Blood Specialists, Shirley

13353

RECRUITING

Charite Universitatsmedizin Berlin Campus Virchow Klinikum, Berlin

19107

RECRUITING

Thomas Jefferson University, Philadelphia

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

20007

SUSPENDED

Georgetown Univ Medical Center Lombardi Cancer Center, Washington D.C.

20089

RECRUITING

Istituto Clinico Humanitas, Rozzano

20133

RECRUITING

Istituto Dei Tumori Di Milano, Milan

21237

SUSPENDED

MedStar Franklin Square Medical Center, Baltimore

22031

RECRUITING

Inova Schar Cancer Institute Dept of Fairfax Hospital, Fairfax

22201

RECRUITING

Virginia Cancer Specialists, Arlington

22763

RECRUITING

Asklepios Klinik Altona, Hamburg

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

27516

RECRUITING

University of North Carolina at Chapel Hill, Chapel Hill

28007

RECRUITING

Hosp. Gral. Univ. Gregorio Maranon, Madrid

28034

RECRUITING

Hosp. Univ. Ramon Y Cajal, Madrid

28041

RECRUITING

Hosp. Univ. 12 de Octubre, Madrid

30303

RECRUITING

Grady Memorial Hospital, Atlanta

30322

RECRUITING

Winship Cancer Institute Emory University, Atlanta

30450

RECRUITING

Hospital Raja Permaisuri Bainun, Ipoh

31008

RECRUITING

Clinica Univ. de Navarra, Pamplona

32804

RECRUITING

AdventHealth Medical Group Oncology and Hematology at Orlando, Orlando

33604

RECRUITING

Hopital Haut Leveque, Pessac

33705

RECRUITING

Florida Cancer Specialists North Region, St. Petersburg

33901

RECRUITING

Florida Cancer Specialists South, Fort Myers

34147

RECRUITING

Bakirkoy Training and Research Hospital, Istanbul

34298

RECRUITING

Institut du Cancer de Montpellier, Montpellier

34899

RECRUITING

Marmara University Pendik Training Hospital, Istanbul

35128

RECRUITING

Istituto Oncologico Veneto - IRCCS, Padua

37203

RECRUITING

SCRI Oncology Partners, Nashville

39401

RECRUITING

Hattiesburg Clinic, Hattiesburg

41013

RECRUITING

Hosp. Virgen Del Rocio, Seville

41404

RECRUITING

Kyungpook National University Chilgok Hospital, Daegu

42090

RECRUITING

Necmettin Erbakan University Meram Medical Faculty, Konya

44000

RECRUITING

CHU Nantes, Nantes

44106

RECRUITING

University Hospitals Cleveland Medical Center, Cleveland

44111

RECRUITING

Cleveland Clinic Cancer Center Fairview Hospital Moll Pavilion, Cleveland

44122

RECRUITING

Cleveland Clinic Cancer Center South Pointe Hospital, Warrensville Heights

44124

RECRUITING

Cleveland Clinic Cancer Center Hillcrest Hospital, Mayfield Heights

44131

RECRUITING

Cleveland Clinic Cancer Center Independence Family Health Center, Independence

44136

RECRUITING

Cleveland Clinic Cancer Center Strongsville, Strongsville

44195

RECRUITING

Taussig Cancer Insititute Cleveland Clinic, Cleveland

44691

RECRUITING

Wooster Milltown Specialty and Surgery Center, Wooster

44870

RECRUITING

Cleveland Clinic Cancer Centers Sandusky, Sandusky

44906

RECRUITING

Cleveland Clinic Cancer Center Mansfield, Mansfield

45147

RECRUITING

Essen University Hospital, Essen

46010

RECRUITING

Hosp. Clinico Univ. de Valencia, Valencia

46804

SUSPENDED

Fort Wayne Medical Oncology & Hematology, Fort Wayne

47014

RECRUITING

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola

48105

RECRUITING

VA Ann Arbor Healthcare System, Ann Arbor

48109

RECRUITING

University of Michigan, Ann Arbor

48202

RECRUITING

Henry Ford Hospital, Detroit

49503

RECRUITING

Start Midwest, Grand Rapids

50586

RECRUITING

Hospital Kuala Lumpur, Kuala Lumpur

52621

RECRUITING

Sheba Medical Center, Ramat Gan

53705

RECRUITING

William S. Middleton Memorial VA, Madison

54290

RECRUITING

Sakarya University Training and Research Hospital, Sakarya

55131

RECRUITING

Universitatsmedizin der Johannes Gutenberg Universitat Mainz, Mainz

56000

RECRUITING

Hospital Canselor Tuanku Muhriz UKM, Cheras

56126

RECRUITING

Azienda Ospedaliero Universitaria Pisana, Pisa

59000

RECRUITING

Hopital Claude Huriez, Lille

59100

RECRUITING

University Malaya Medical Centre, Kuala Lumpur

60488

RECRUITING

Krankenhaus NorthWest, Frankfurt am Main

62250

RECRUITING

National Cancer Institute, Putrajaya

63110

RECRUITING

Washington University School Of Medicine, St Louis

68130

RECRUITING

Nebraska Cancer Specialists Midwest Cancer Center, Omaha

69008

RECRUITING

Hopital Prive Jean Mermoz, Lyon

69120

RECRUITING

National Center for Tumor Diseases NCT, Heidelberg

69710

RECRUITING

Assuta MC, Tel Aviv

70121

RECRUITING

Ochsner Clinic Foundation, New Orleans

70300

RECRUITING

Yitzhak Shamir Medical Center, Beer Yaakov

72401

RECRUITING

St. Bernard's Medical Center, Jonesboro

75246

RECRUITING

Texas Oncology DFW, Dallas

75390

RECRUITING

UT Southwestern, Dallas

75571

RECRUITING

Hopital Saint Antoine, Paris

76508

RECRUITING

Baylor Scott and White Health, Temple

77030

RECRUITING

MD Anderson Cancer Center, Houston

78240

RECRUITING

Texas Oncology - San Antonio, San Antonio

79110

RECRUITING

Praxis fur interdisziplinare Onkologie & Hamatologie GbR, Freiburg im Breisgau

79606

RECRUITING

Texas Oncology West Texas, Abilene

80218

RECRUITING

Rocky Mountain Cancer Centers, Denver

80756

RECRUITING

Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung City

81377

RECRUITING

Klinikum der Universitaet Muenchen, Munich

83301

RECRUITING

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

84918

RECRUITING

Institut Sainte Catherine, Avignon

85234

RECRUITING

Banner MD Anderson Cancer Center, Gilbert

86000

RECRUITING

CHU De Poitiers, Poitiers

87102

RECRUITING

University of New Mexico Cancer Center, Albuquerque

89081

RECRUITING

Universitatsklinikum Ulm, Ulm

89169

RECRUITING

Comprehensive Cancer Centers of Nevada, Las Vegas

90033

RECRUITING

USC Norris Comprehensive Cancer Center, Los Angeles

90404

RECRUITING

UCLA, Santa Monica

90505

RECRUITING

Torrance Memorial Physicians Network, Torrance

90720

RECRUITING

Cancer and Blood Specialty Clinic, Los Alamitos

91204

RECRUITING

Los Angeles Cancer Network, Glendale

93309

RECRUITING

CBCC Global Research, Bakersfield

93586

RECRUITING

Hospital Umum Sarawak, Kuching

94805

RECRUITING

Gustave Roussy, Villejuif

95403

RECRUITING

Providence Medical Foundation, Santa Rosa

98026

RECRUITING

Swedish Cancer Institute, Edmonds

98029

RECRUITING

Swedish Cancer Institute, Issaquah

98104

RECRUITING

Swedish Cancer Institute, Seattle

98109

RECRUITING

Fred Hutchinson Cancer Research Center, Seattle

100034

RECRUITING

Peking University First Hospital, Beijing

100050

RECRUITING

Beijing Friendship Hospital Capital Medical University, Beijing

100142

RECRUITING

Beijing Cancer Hospital, Beijing

100191

RECRUITING

Peking University Third Hospital, Beijing

110042

RECRUITING

Liaoning Cancer Hospital and Institute, Shenyang

110085

RECRUITING

Rajiv Gandhi Cancer Institute and Research Centre, Delhi

130021

RECRUITING

The First Bethune Hospital of Jilin University, Changchun

150081

RECRUITING

Harbin medical university cancer hospital, Harbin

200032

RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

221005

RECRUITING

Mahamana Pandit Madan Mohan Malviya Cancer Centre, Varanasi

300060

RECRUITING

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310003

RECRUITING

The First Affiliated Hospital Zhejiang University College of Medicine, Hangzhou

310009

RECRUITING

The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou

310022

RECRUITING

Zhejiang Cancer Hospital, Hangzhou

330006

RECRUITING

The First Affiliated Hospital of NanChang University, Nanchang

400012

RECRUITING

Tata Memorial Hospital, Mumbai

410013

RECRUITING

Hunan Cancer hospital, Changsha

411004

RECRUITING

Deenanath Mangeshkar Hospital and Research Centre, Pune

430079

RECRUITING

Hubei Cancer Hospital, Wuhan

510062

RECRUITING

Sun Yat Sen University Cancer Center, Guangzhou

510655

RECRUITING

The Sixth Affiliated Hospital Sun Yat sen University, Guangzhou

516001

RECRUITING

Huizhou Central People's Hospital, Huizhou

518036

RECRUITING

Peking University Shenzhen Hospital, Shenzhen

519041

RECRUITING

Guangdong Provincial People's Hospital, Guangzhou

610044

RECRUITING

West China Hospital of Sichuan University, Sichuan

700053

RECRUITING

B P Poddar Hospital and Medical research Limited, Kolkata

3109601

RECRUITING

Rambam Medical Center, Haifa

4941492

RECRUITING

Rabin Medical Center, Petah Tikva

6423906

RECRUITING

Tel Aviv Sourasky Medical Center, Tel Aviv

9112001

RECRUITING

Hadassah University Hospita Ein Kerem, Jerusalem

06519

RECRUITING

Yale University School Of Medicine, New Haven

33401-3406

RECRUITING

Florida Cancer Specialists East, West Palm Beach

08816

RECRUITING

Astera Cancer Care, East Brunswick

08901

RECRUITING

Rutgers Cancer Institute, New Brunswick

15232 1301

RECRUITING

University Of Pittsburgh Medical Center UPMC Hillman Cancer Center, Pittsburgh

14780 070

RECRUITING

Fundacao Pio XII, Barretos

95070 560

RECRUITING

Fundacao Universidade de Caxias do Sul, Caxias do Sul

17210 080

RECRUITING

Fundacao Doutor Amaral Carvalho, Jaú

91350 200

RECRUITING

Hospital Nossa Senhora da Conceicao S A, Porto Alegre

40050 410

RECRUITING

Hospital Santa Izabel Santa Casa de Misericordia da Bahia, Salvador

97015 450

RECRUITING

Clinica de Hematologia e Oncologia Viver Ltda, Santa Maria

15090 000

RECRUITING

Fundacao Faculdade Regional De Medicina S Jose Rio Preto Hospital De Base, São José do Rio Preto

01246 000

RECRUITING

Fundacao Faculdade de Medicina - Instituto do Cancer do Estado de Sao Paulo, São Paulo

01509 900

RECRUITING

Fundacao Antonio Prudente A C Camargo Cancer Center, São Paulo

05651 900

RECRUITING

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo

29043 260

RECRUITING

Associacao Feminina de Educacao e Combate ao Cancer Hospital Santa Rita de Cassia, Vitória

T2N 5G2

RECRUITING

Arthur J E Child Comprehensive Cancer Centre, Calgary

K1H 8L6

RECRUITING

Ottawa Hospital, Ottawa

M5G1X6

RECRUITING

Princess Margaret Cancer Centre, Toronto

H2X 0C1

RECRUITING

Centre de Recherche du CHUM, Montreal

030001

RECRUITING

First Hospital of Shanxi Medical University, Taiyuan

01307

RECRUITING

Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden

260 0801

RECRUITING

Chiba Cancer Center, Chiba

104 0045

RECRUITING

National Cancer Center Hospital, Chūōku

277 8577

RECRUITING

National Cancer Center Hospital East, Kashiwa

464 8681

RECRUITING

Aichi Cancer Center, Nagoya

540 0006

RECRUITING

National Hospital Organization Osaka National Hospital, Osaka

541 8567

RECRUITING

Osaka International Cancer Institute, Osaka

411 8777

RECRUITING

Shizuoka Cancer Center, Shizuoka

565 0871

RECRUITING

The University of Osaka Hospital, Suita

135 8550

RECRUITING

The Cancer Institute Hospital of JFCR, Tokyo

3813 TZ

RECRUITING

Meander Medisch Centrum, Amersfoort

1066 CX

RECRUITING

Antoni van Leeuwenhoek, Amsterdam

6525 GA

RECRUITING

Radboud University Medical Center, Nijmegen

3015 GD

RECRUITING

Erasmus MC, Rotterdam

5022 GC

RECRUITING

Elisabeth-TweeSteden Ziekenhuis, Tilburg

3584 CX

RECRUITING

UMC Utrecht, Utrecht

15 027

RECRUITING

Bialostockie Centrum Onkologii im Marii Sklodowskiej Curie w Bialymstoku, Bialystok

21 500

RECRUITING

Wojewodzki Szpital Specjalistyczny, Biała Podlaska

36 200

RECRUITING

Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza, Brzozów

80 214

RECRUITING

Uniwersyteckie Centrum Kliniczne, Gdansk

44 100

RECRUITING

Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut BadawczyOddz w Gliwicach, Gliwice

93 339

RECRUITING

Instytut Centrum Zdrowia Matki Polki, Lodz

10 228

RECRUITING

SPZOZ Ministerstwa Spraw Wewnetrznych z Warminsko Mazurskim Centrum Onkologii w Olsztynie, Olsztyn

45 061

RECRUITING

SPZOZ Opolskie Centrum Onkologii im. Prof. Tadeusza Koszarowskiego, Opole

02 781

RECRUITING

Centrum Onkologii - Instytut im. Marii Sklodowskiej-Curie, Warsaw

00935

RECRUITING

Pan American Center for Oncology Trials LLC, Barrio Monacillos

03080

RECRUITING

Seoul National University Hospital, Seoul

03722

RECRUITING

Severance Hospital Yonsei University Health System, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

06591

RECRUITING

The Catholic University of Korea Seoul St Marys Hospital, Seoul

08025

RECRUITING

Hosp. de La Santa Creu I Sant Pau, Barcelona

08035

RECRUITING

Hosp Univ Vall D Hebron, Barcelona

413 45

RECRUITING

Sahlgrenska University Hospital, Gothenburg

222 42

RECRUITING

Skanes universitetssjukhus, Lund

118 83

RECRUITING

Sodersjukhuset, Stockholm

171 76

RECRUITING

Karolinska Universitetssjukhuset, Stockholm

SE 751 85

RECRUITING

Uppsala University, Uppsala

01060

RECRUITING

Adana City Hospital, Adana

06010

RECRUITING

Gulhane Egitim ve Arastirma Hastanesi, Ankara

06200

RECRUITING

Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara

06560

RECRUITING

Gazi University Hospital, Ankara

06800

RECRUITING

Ankara Bilkent Sehir Hastanesi, Ankara

B9 5ST

RECRUITING

Birmingham Heartlands Hospital, Birmingham

CB2 0QQ

RECRUITING

Addenbrooke's Hospital, Cambridge

EH4 2XU

RECRUITING

Western General Hospital, Edinburgh

HU16 5JQ

RECRUITING

Castle Hill Hospital, Hull

LS9 7TF

RECRUITING

St James University Hospital, Leeds

EC1A 7BE

RECRUITING

St Bartholomew's Hospital, London

NW1 2BU

RECRUITING

University College Hospital, London

HA6 2RN

RECRUITING

Mount Vernon Cancer Centre, Northwood

SM2 5PT

RECRUITING

Royal Marsden Hospital (Sutton), Sutton

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY