1,040
Participants
Start Date
March 14, 2025
Primary Completion Date
November 30, 2037
Study Completion Date
November 30, 2037
Pembrolizumab
Given intravenously
Tivozanib
Given orally
Biospecimen Collection
Undergo blood sample collection
MRI
Undergo MRI
Computed Tomography
Undergo CT scan
Biopsy
Undergo biopsy
Questionnaire Administration
Ancillary studies
RECRUITING
Mount Sinai Chelsea, New York
RECRUITING
Mount Sinai Hospital, New York
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
Memorial Sloan Kettering Westchester, Harrison
RECRUITING
Memorial Sloan Kettering Nassau, Uniondale
RECRUITING
Memorial Sloan Kettering Commack, Commack
RECRUITING
Glens Falls Hospital, Glens Falls
RECRUITING
Hematology Oncology Associates of CNY at Camillus, Camillus
RECRUITING
Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse
RECRUITING
Roswell Park Cancer Institute, Buffalo
RECRUITING
UPMC-Heritage Valley Health System Beaver, Beaver
RECRUITING
UPMC Hillman Cancer Center - Monroeville, Monroeville
RECRUITING
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh
RECRUITING
UPMC-Passavant Hospital, Pittsburgh
RECRUITING
UPMC-Saint Clair Hospital Cancer Center, Pittsburgh
RECRUITING
UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg
RECRUITING
UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown
RECRUITING
UPMC Hillman Cancer Center at Butler Health System, Butler
RECRUITING
UPMC Hillman Cancer Center Erie, Erie
RECRUITING
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg
RECRUITING
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg
RECRUITING
Divine Providence Hospital, Williamsport
RECRUITING
Geisinger Medical Center, Danville
RECRUITING
Geisinger Medical Oncology-Lewisburg, Lewisburg
RECRUITING
Lehigh Valley Hospital - Muhlenberg, Bethlehem
RECRUITING
Lehigh Valley Hospital-Cedar Crest, Allentown
RECRUITING
Geisinger Medical Center-Cancer Center Hazleton, Hazleton
RECRUITING
Lehigh Valley Hospital-Hazleton, Hazleton
RECRUITING
Pocono Medical Center, East Stroudsburg
RECRUITING
Community Medical Center, Scranton
RECRUITING
Geisinger Cancer Center Dickson City, Dickson City
RECRUITING
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre
RECRUITING
Thomas Jefferson University Hospital, Philadelphia
RECRUITING
Jefferson Torresdale Hospital, Philadelphia
RECRUITING
Helen F Graham Cancer Center, Newark
RECRUITING
Medical Oncology Hematology Consultants PA, Newark
RECRUITING
Beebe South Coastal Health Campus, Millville
RECRUITING
Beebe Health Campus, Rehoboth Beach
RECRUITING
MedStar Washington Hospital Center, Washington D.C.
RECRUITING
George Washington University Medical Center, Washington D.C.
RECRUITING
UPMC Western Maryland, Cumberland
RECRUITING
Bon Secours Saint Francis Medical Center, Midlothian
RECRUITING
Bon Secours Memorial Regional Medical Center, Mechanicsville
RECRUITING
Bon Secours Saint Mary's Hospital, Richmond
RECRUITING
VCU Massey Cancer Center at Stony Point, Richmond
RECRUITING
VCU Massey Comprehensive Cancer Center, Richmond
RECRUITING
West Virginia University Charleston Division, Charleston
SUSPENDED
WVUH-Berkely Medical Center, Martinsburg
SUSPENDED
Camden Clark Medical Center, Parkersburg
SUSPENDED
United Hospital Center, Bridgeport
SUSPENDED
West Virginia University Healthcare, Morgantown
RECRUITING
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
RECRUITING
FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst
RECRUITING
Prisma Health Cancer Institute - Spartanburg, Boiling Springs
RECRUITING
Medical University of South Carolina, Charleston
RECRUITING
Prisma Health Cancer Institute - Butternut, Greenville
RECRUITING
Prisma Health Cancer Institute - Faris, Greenville
RECRUITING
Prisma Health Cancer Institute - Eastside, Greenville
RECRUITING
Prisma Health Cancer Institute - Easley, Easley
RECRUITING
Prisma Health Cancer Institute - Greer, Greer
RECRUITING
Prisma Health Cancer Institute - Seneca, Seneca
RECRUITING
University of Florida Health Science Center - Gainesville, Gainesville
RECRUITING
Miami Cancer Institute, Miami
RECRUITING
Vanderbilt University/Ingram Cancer Center, Nashville
RECRUITING
Baptist Memorial Hospital and Cancer Center-Collierville, Collierville
RECRUITING
Baptist Memorial Hospital and Cancer Center-Memphis, Memphis
RECRUITING
Baptist Memorial Hospital and Cancer Center-Union County, New Albany
RECRUITING
Baptist Memorial Hospital and Cancer Center-Oxford, Oxford
RECRUITING
Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven
RECRUITING
Baptist Cancer Center-Grenada, Grenada
RECRUITING
Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus
RECRUITING
Baptist Health Louisville, Louisville
RECRUITING
Ohio State University Comprehensive Cancer Center, Columbus
RECRUITING
UH Seidman Cancer Center at UH Avon Health Center, Avon
RECRUITING
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor
RECRUITING
Case Western Reserve University, Cleveland
RECRUITING
UHHS-Chagrin Highlands Medical Center, Beachwood
RECRUITING
Aultman Health Foundation, Canton
RECRUITING
Kettering Medical Center, Kettering
SUSPENDED
Indu and Raj Soin Medical Center, Beavercreek
RECRUITING
IU Health North Hospital, Carmel
RECRUITING
IU Health West Hospital, Avon
RECRUITING
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea
RECRUITING
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti
RECRUITING
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac
RECRUITING
Cancer Hematology Centers - Flint, Flint
RECRUITING
Genesee Hematology Oncology PC, Flint
RECRUITING
Genesys Hurley Cancer Institute, Flint
RECRUITING
University of Michigan Health - Sparrow Lansing, Lansing
RECRUITING
Bronson Methodist Hospital, Kalamazoo
RECRUITING
West Michigan Cancer Center, Kalamazoo
RECRUITING
Bronson Battle Creek, Battle Creek
RECRUITING
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
RECRUITING
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
RECRUITING
Corewell Health Lakeland Hospitals - Niles Hospital, Niles
RECRUITING
Trinity Health Muskegon Hospital, Muskegon
RECRUITING
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores
RECRUITING
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
RECRUITING
Trinity Health Grand Rapids Hospital, Grand Rapids
RECRUITING
University of Michigan Health - West, Wyoming
RECRUITING
Corewell Health Reed City Hospital, Reed City
RECRUITING
Munson Medical Center, Traverse City
RECRUITING
Mary Greeley Medical Center, Ames
RECRUITING
McFarland Clinic - Ames, Ames
RECRUITING
McFarland Clinic - Boone, Boone
RECRUITING
McFarland Clinic - Jefferson, Jefferson
RECRUITING
McFarland Clinic - Marshalltown, Marshalltown
RECRUITING
McFarland Clinic - Trinity Cancer Center, Fort Dodge
RECRUITING
Mercy Hospital, Cedar Rapids
RECRUITING
Oncology Associates at Mercy Medical Center, Cedar Rapids
RECRUITING
Aurora Health Care Germantown Health Center, Germantown
RECRUITING
Aurora Cancer Care-Grafton, Grafton
RECRUITING
Froedtert Menomonee Falls Hospital, Menomonee Falls
RECRUITING
ProHealth Oconomowoc Memorial Hospital, Oconomowoc
RECRUITING
Aurora Medical Center in Summit, Summit
RECRUITING
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan
RECRUITING
Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend
RECRUITING
Aurora Cancer Care-Southern Lakes VLCC, Burlington
RECRUITING
Aurora Saint Luke's South Shore, Cudahy
RECRUITING
Aurora Cancer Care-Kenosha South, Kenosha
RECRUITING
ProHealth D N Greenwald Center, Mukwonago
RECRUITING
Drexel Town Square Health Center, Oak Creek
RECRUITING
ProHealth Waukesha Memorial Hospital, Waukesha
RECRUITING
UW Cancer Center at ProHealth Care, Waukesha
RECRUITING
Aurora Cancer Care-Milwaukee, Milwaukee
RECRUITING
Aurora Saint Luke's Medical Center, Milwaukee
RECRUITING
Medical College of Wisconsin, Milwaukee
RECRUITING
Aurora Cancer Care-Milwaukee West, Wauwatosa
RECRUITING
Aurora West Allis Medical Center, West Allis
RECRUITING
Aurora Sinai Medical Center, Milwaukee
RECRUITING
Aurora Cancer Care-Racine, Racine
RECRUITING
Aurora Bay Area Medical Group-Marinette, Marinette
RECRUITING
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers
RECRUITING
Aurora BayCare Medical Center, Green Bay
RECRUITING
Gundersen Lutheran Medical Center, La Crosse
RECRUITING
Duluth Clinic Ashland, Ashland
RECRUITING
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh
RECRUITING
Essentia Health Sandstone, Sandstone
RECRUITING
Regions Hospital, Saint Paul
RECRUITING
Fairview Southdale Hospital, Edina
RECRUITING
Essentia Health Hibbing Clinic, Hibbing
RECRUITING
Essentia Health Virginia Clinic, Virginia
RECRUITING
Essentia Health Cancer Center, Duluth
RECRUITING
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud
RECRUITING
Essentia Health Saint Joseph's Medical Center, Brainerd
RECRUITING
Sanford Joe Lueken Cancer Center, Bemidji
RECRUITING
Essentia Health - Deer River Clinic, Deer River
RECRUITING
Sanford Cancer Center Oncology Clinic, Sioux Falls
RECRUITING
Essentia Health Cancer Center-South University Clinic, Fargo
RECRUITING
Sanford Broadway Medical Center, Fargo
RECRUITING
Sanford Roger Maris Cancer Center, Fargo
RECRUITING
Sanford Bismarck Medical Center, Bismarck
RECRUITING
Billings Clinic Cancer Center, Billings
RECRUITING
Benefis Sletten Cancer Institute, Great Falls
RECRUITING
Community Hospital of Anaconda, Anaconda
RECRUITING
Bozeman Health Deaconess Hospital, Bozeman
RECRUITING
Community Medical Center, Missoula
RECRUITING
Logan Health Medical Center, Kalispell
RECRUITING
Advocate Good Shepherd Hospital, Barrington
RECRUITING
AMG Crystal Lake - Oncology, Crystal Lake
RECRUITING
Northwestern Medicine Glenview Outpatient Center, Glenview
RECRUITING
Northwestern Medicine Grayslake Outpatient Center, Grayslake
RECRUITING
Northwestern Medicine Lake Forest Hospital, Lake Forest
RECRUITING
AMG Libertyville - Oncology, Libertyville
RECRUITING
Condell Memorial Hospital, Libertyville
RECRUITING
Advocate Lutheran General Hospital, Park Ridge
RECRUITING
Northwestern Medicine Cancer Center Kishwaukee, DeKalb
RECRUITING
Advocate Sherman Hospital, Elgin
RECRUITING
Northwestern Medicine Cancer Center Delnor, Geneva
RECRUITING
Advocate South Suburban Hospital, Hazel Crest
RECRUITING
Advocate Outpatient Center - Oak Lawn, Oak Lawn
RECRUITING
Northwestern Medicine Orland Park, Orland Park
RECRUITING
Advocate High Tech Medical Park, Palos Heights
RECRUITING
Rush-Copley Medical Center, Aurora
RECRUITING
Advocate Outpatient Center - Aurora, Aurora
RECRUITING
Advocate Good Samaritan Hospital, Downers Grove
RECRUITING
Northwestern Medicine Oak Brook, Oak Brook
RECRUITING
Northwestern Medicine Cancer Center Warrenville, Warrenville
RECRUITING
Rush-Copley Healthcare Center, Yorkville
RECRUITING
Northwestern University, Chicago
RECRUITING
University of Illinois, Chicago
RECRUITING
Advocate Illinois Masonic Medical Center, Chicago
RECRUITING
Illinois CancerCare-Dixon, Dixon
RECRUITING
Illinois CancerCare-Ottawa Clinic, Ottawa
RECRUITING
Illinois CancerCare-Peru, Peru
RECRUITING
Illinois CancerCare-Princeton, Princeton
RECRUITING
Illinois CancerCare-Galesburg, Galesburg
RECRUITING
Illinois CancerCare-Kewanee Clinic, Kewanee
RECRUITING
Illinois CancerCare-Macomb, Macomb
RECRUITING
Illinois CancerCare-Canton, Canton
RECRUITING
Illinois CancerCare-Eureka, Eureka
RECRUITING
Illinois CancerCare-Pekin, Pekin
RECRUITING
Illinois CancerCare - Washington, Washington
RECRUITING
Illinois CancerCare-Peoria, Peoria
RECRUITING
Illinois CancerCare-Bloomington, Bloomington
RECRUITING
Cancer Care Center of O'Fallon, O'Fallon
RECRUITING
Memorial Hospital East, Shiloh
RECRUITING
Illinois CancerCare-Carthage, Carthage
RECRUITING
Crossroads Cancer Center, Effingham
RECRUITING
Cancer Care Specialists of Illinois - Decatur, Decatur
RECRUITING
Decatur Memorial Hospital, Decatur
RECRUITING
Southern Illinois University School of Medicine, Springfield
RECRUITING
Springfield Clinic, Springfield
RECRUITING
Springfield Memorial Hospital, Springfield
RECRUITING
SIH Cancer Institute, Carterville
RECRUITING
Missouri Baptist Sullivan Hospital, Sullivan
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
BJC Outpatient Center at Sunset Hills, Sunset Hills
RECRUITING
Mercy Hospital South, St Louis
RECRUITING
Siteman Cancer Center-South County, St Louis
RECRUITING
Missouri Baptist Medical Center, St Louis
RECRUITING
Siteman Cancer Center at Christian Hospital, St Louis
RECRUITING
Siteman Cancer Center at West County Hospital, Creve Coeur
RECRUITING
Mercy Hospital Saint Louis, St Louis
RECRUITING
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
RECRUITING
Parkland Health Center - Farmington, Farmington
RECRUITING
Sainte Genevieve County Memorial Hospital, Sainte Genevieve
RECRUITING
Saint Francis Medical Center, Cape Girardeau
RECRUITING
Ochsner Medical Center Jefferson, New Orleans
RECRUITING
University of Arkansas for Medical Sciences, Little Rock
RECRUITING
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
Cancer Centers of Southwest Oklahoma Research, Lawton
RECRUITING
Houston Methodist Hospital, Houston
RECRUITING
Houston Methodist Saint John Hospital, Nassau Bay
RECRUITING
Methodist Willowbrook Hospital, Houston
RECRUITING
Houston Methodist West Hospital, Houston
RECRUITING
Houston Methodist The Woodlands Hospital, The Woodlands
RECRUITING
Houston Methodist Cypress Hospital, Cypress
RECRUITING
Houston Methodist Sugar Land Hospital, Sugar Land
RECRUITING
Houston Methodist San Jacinto Hospital, Baytown
RECRUITING
The Don and Sybil Harrington Cancer Center, Amarillo
RECRUITING
Kootenai Health - Coeur d'Alene, Coeur d'Alene
RECRUITING
Kootenai Clinic Cancer Services - Post Falls, Post Falls
RECRUITING
Kootenai Clinic Cancer Services - Sandpoint, Sandpoint
SUSPENDED
Cancer Center at Saint Joseph's, Phoenix
RECRUITING
University of New Mexico Cancer Center, Albuquerque
RECRUITING
Los Angeles General Medical Center, Los Angeles
RECRUITING
USC / Norris Comprehensive Cancer Center, Los Angeles
RECRUITING
City of Hope South Bay, Torrance
RECRUITING
City of Hope Comprehensive Cancer Center, Duarte
RECRUITING
City of Hope Upland, Upland
RECRUITING
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
RECRUITING
City of Hope at Irvine Lennar, Irvine
RECRUITING
USC Norris Oncology/Hematology-Newport Beach, Newport Beach
RECRUITING
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
RECRUITING
City of Hope Antelope Valley, Lancaster
RECRUITING
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale
RECRUITING
California Pacific Medical Center-Pacific Campus, San Francisco
RECRUITING
Palo Alto Medical Foundation Health Care, Palo Alto
RECRUITING
Mills Health Center, San Mateo
RECRUITING
Sutter Solano Medical Center/Cancer Center, Vallejo
RECRUITING
Palo Alto Medical Foundation-Santa Cruz, Santa Cruz
RECRUITING
Sutter Auburn Faith Hospital, Auburn
RECRUITING
Sutter Roseville Medical Center, Roseville
RECRUITING
Sutter Medical Center Sacramento, Sacramento
RECRUITING
University of California Davis Comprehensive Cancer Center, Sacramento
RECRUITING
Oregon Health and Science University, Portland
RECRUITING
Smilow Cancer Hospital-Derby Care Center, Derby
RECRUITING
Smilow Cancer Hospital Care Center-Fairfield, Fairfield
RECRUITING
Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury
RECRUITING
Smilow Cancer Hospital Care Center at Greenwich, Greenwich
RECRUITING
Smilow Cancer Hospital Care Center - Guilford, Guilford
RECRUITING
Smilow Cancer Hospital Care Center at Saint Francis, Hartford
RECRUITING
Yale University, New Haven
RECRUITING
Yale-New Haven Hospital North Haven Medical Center, North Haven
RECRUITING
Smilow Cancer Hospital Care Center at Long Ridge, Stamford
RECRUITING
Stamford Hospital/Bennett Cancer Center, Stamford
RECRUITING
Smilow Cancer Hospital-Torrington Care Center, Torrington
RECRUITING
Smilow Cancer Hospital Care Center-Trumbull, Trumbull
RECRUITING
Smilow Cancer Hospital-Waterbury Care Center, Waterbury
RECRUITING
Smilow Cancer Hospital Care Center - Waterford, Waterford
RECRUITING
Advocate Christ Medical Center, Oak Lawn
RECRUITING
Lafayette Family Cancer Center-EMMC, Brewer
RECRUITING
Dana-Farber Cancer Institute, Boston
RECRUITING
Lahey Hospital and Medical Center, Burlington
RECRUITING
Dana-Farber Cancer Institute at Foxborough, Foxborough
RECRUITING
Dana Farber-Merrimack Valley, Methuen
RECRUITING
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional, Milford
RECRUITING
Lahey Medical Center-Peabody, Peabody
RECRUITING
Dana-Farber/Brigham and Women's Cancer Center at South Shore, South Weymouth
RECRUITING
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
RECRUITING
Memorial Sloan Kettering Basking Ridge, Basking Ridge
RECRUITING
Jefferson Cherry Hill Hospital, Cherry Hill
RECRUITING
The Cancer Institute of New Jersey Hamilton, Hamilton
RECRUITING
Monmouth Medical Center, Long Branch
RECRUITING
Memorial Sloan Kettering Monmouth, Middletown
RECRUITING
Memorial Sloan Kettering Bergen, Montvale
RECRUITING
Morristown Medical Center, Morristown
RECRUITING
Rutgers Cancer Institute of New Jersey, New Brunswick
RECRUITING
Rutgers New Jersey Medical School, Newark
RECRUITING
Sidney Kimmel Cancer Center Washington Township, Sewell
RECRUITING
Robert Wood Johnson University Hospital Somerset, Somerville
RECRUITING
Overlook Hospital, Summit
RECRUITING
Smilow Cancer Hospital Care Center - Westerly, Westerly
RECRUITING
Sanford USD Medical Center - Sioux Falls, Sioux Falls
RECRUITING
Dartmouth Cancer Center - North, Saint Johnsbury
Alliance for Clinical Trials in Oncology
OTHER