Streamlined Treatment of Pulmonary Exacerbations in Pediatrics

NARecruitingINTERVENTIONAL
Enrollment

430

Participants

Timeline

Start Date

December 1, 2024

Primary Completion Date

December 30, 2027

Study Completion Date

February 28, 2029

Conditions
Cystic Fibrosis
Interventions
OTHER

Immediate Oral Antibiotics

Increase airway clearance and start 14 days of preselected oral antibiotics right away

OTHER

Tailored Treatment: Oral Antibiotics only if Additional Treatment needed

Increase airway clearance and start preselected oral antibiotics later if symptoms get worse or do not get better according to prespecified criteria

Trial Locations (33)

14642

RECRUITING

University of Rochester Medical Center Strong Memorial, Rochester

15224

NOT_YET_RECRUITING

Children's Hospital of Pittsburgh of UPMC & University of Pittsburgh Medical Center, Pittsburgh

19104

RECRUITING

Children's Hospital of Philadelphia & University of Pennsylvania, Philadelphia

21287

NOT_YET_RECRUITING

Johns Hopkins Hospital, Johns Hopkins University, Baltimore

23298

NOT_YET_RECRUITING

Virginia Commonwealth University, Richmond

27514

NOT_YET_RECRUITING

University of North Carolina at Chapel Hill, Chapel Hill

29425

NOT_YET_RECRUITING

Medical University of South Carolina, Charleston

30322

RECRUITING

Children's Healthcare of Atlanta & Emory University, Atlanta

35233

RECRUITING

The Children's Hospital Alabama & University of Alabama at Birmingham, Birmingham

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

46202

RECRUITING

Riley Hospital for Children & Indiana University, Indianapolis

52242

NOT_YET_RECRUITING

University of Iowa, Iowa City

53226

NOT_YET_RECRUITING

Children's Wisconsin & Medical College of Wisconsin, Milwaukee

53792

RECRUITING

University of Wisconsin, Madison

55404

RECRUITING

Children's Hospitals and Clinics of Minnesota, Minneapolis

55455

NOT_YET_RECRUITING

The Minnesota Cystic Fibrosis Center & University of Minnesota, Minneapolis

60611

NOT_YET_RECRUITING

Ann & Robert H. Lurie Children's Hospital of Chicago & Northwestern University, Chicago

63110

RECRUITING

St. Louis Children's Hospital & Washington University School of Medicine, St Louis

64108

RECRUITING

Children's Mercy Hospital, Kansas City

75235

RECRUITING

University of Texas Southwestern & Children's Health, Dallas

77030

NOT_YET_RECRUITING

Texas Children's Hospital & Baylor College of Medicine, Houston

80045

RECRUITING

Children's Hospital of Colorado, Aurora

85713

NOT_YET_RECRUITING

Tucson Cystic Fibrosis Center, Tucson

90027

RECRUITING

Children's Hospital of Los Angeles & Anton Yelchin Cystic Fibrosis Clinic, Los Angeles

92123

NOT_YET_RECRUITING

Rady Children's Hospital at University of California San Diego, San Diego

94304

NOT_YET_RECRUITING

Stanford University, Palo Alto

98105

RECRUITING

Seattle Children's Hospital, Seattle

02115

RECRUITING

Boston Children's Hospital & Harvard University, Boston

48109-5212

RECRUITING

University of Michigan Health System, Ann Arbor

97239-3098

RECRUITING

Oregon Health & Science University, Portland

05401

RECRUITING

Vermont Children's Hospital & University of Vermont Medical Center, Burlington

V6H 3V4

NOT_YET_RECRUITING

British Columbia Children's Hospital, Vancouver

M5G 0A4

NOT_YET_RECRUITING

The Hospital for Sick Children & Toronto Canada CF Centre Pediatrics, Toronto

All Listed Sponsors
collaborator

Cystic Fibrosis Foundation

OTHER

lead

University of Washington, the Collaborative Health Studies Coordinating Center

OTHER