Revumenib in Combination With Azacitidine + Venetoclax in Patients NPM1-mutated or KMT2A-rearranged AML

PHASE3RecruitingINTERVENTIONAL
Enrollment

415

Participants

Timeline

Start Date

March 31, 2025

Primary Completion Date

December 13, 2029

Study Completion Date

July 10, 2031

Conditions
Acute Myeloid Leukemia, Adult
Interventions
DRUG

Revumenib

day 1- 28 per cycle

DRUG

Placebo

day 1- 28 per cycle

Trial Locations (67)

Unknown

NOT_YET_RECRUITING

DE-Berlin-CAMPUSBENFRANKLIN, Berlin

NOT_YET_RECRUITING

DE-Berlin-CAMPUSVIRCHOW, Berlin

NOT_YET_RECRUITING

DE-Berlin-VIVANTESNEUKOLLN, Berlin

NOT_YET_RECRUITING

DE-Bochum-RUB, Bochum

NOT_YET_RECRUITING

DE-Bonn-UNIBONN, Bonn

NOT_YET_RECRUITING

DE-Braunschweig-KLINIKUMBRAUNSCHWEIG, Braunschweig

NOT_YET_RECRUITING

DE-Bremen-KBM, Bremen

NOT_YET_RECRUITING

DE-Darmstadt-KLINIKUMDARMSTADT, Darmstadt

NOT_YET_RECRUITING

DE-Essen-KEM, Essen

NOT_YET_RECRUITING

DE-Flensburg-MALTESER, Flensburg

NOT_YET_RECRUITING

DE-Frankfurt-KLINIKUMFRANKFURT, Frankfurt

NOT_YET_RECRUITING

DE-Freiburg-UNIKLINIKFREIBURG, Freiburg im Breisgau

NOT_YET_RECRUITING

DE-Greifswald-UNIGREIFSWALD, Greifswald

NOT_YET_RECRUITING

DE-Hamburg-ASKLEPIOSSTGEORG, Hamburg

NOT_YET_RECRUITING

DE-Hamburg-UKE, Hamburg

NOT_YET_RECRUITING

DE-Hannover-MHHANNOVER, Hanover

NOT_YET_RECRUITING

DE-Hannover-SILOAHKRH, Hanover

NOT_YET_RECRUITING

DE-Heilbronn-SLK General Information, Heilbronn

NOT_YET_RECRUITING

DE-Herne-MARIENHOSPITALHERNE, Herne

NOT_YET_RECRUITING

DE-Karlsruhe-KLINIKUMKARLSRUHE, Karlsruhe

NOT_YET_RECRUITING

DE-Mainz-UNIMEDIZINMAINZ, Mainz

NOT_YET_RECRUITING

DE-Minden-MUEHLENKREISKLINKEN, Minden

NOT_YET_RECRUITING

DE-München-IRZTUM, München

NOT_YET_RECRUITING

DE-Oldenburg-KLINIKUMOLDENBURG, Oldenburg

NOT_YET_RECRUITING

DE-Potsdam-BERGMANN, Potsdam

NOT_YET_RECRUITING

DE-Stuttgart-KLINIKUMSTUTTGART, Stuttgart

NOT_YET_RECRUITING

DE-Tübingen-MEDUNITUEBINGEN, Tübingen

NOT_YET_RECRUITING

DE-Ulm-UNIKLINKULM, Ulm

NOT_YET_RECRUITING

DE-Wuppertal-HELIOSGESUNDHEIT, Wuppertal

NOT_YET_RECRUITING

NL-Den Bosch-JBZ, 's-Hertogenbosch

NOT_YET_RECRUITING

NL-Amersfoort-MEANDERMC, Amersfoort

NOT_YET_RECRUITING

NL-Amsterdam-OLVG, Amsterdam

NOT_YET_RECRUITING

NL-Amsterdam-VUMC, Amsterdam

NOT_YET_RECRUITING

NL-Arnhem-RIJNSTATE, Arnhem

NOT_YET_RECRUITING

NL-Breda-AMPHIA, Breda

NOT_YET_RECRUITING

NL-Delft-RDGG, Delft

NOT_YET_RECRUITING

NL-Eindhoven-MAXIMAMC, Eindhoven

NOT_YET_RECRUITING

NL-Enschede-MST, Enschede

NOT_YET_RECRUITING

NL-Goes-ADRZ, Goes

RECRUITING

NL-Groningen-UMCG, Groningen

NOT_YET_RECRUITING

NL-Leeuwarden-MCL, Leeuwarden

NOT_YET_RECRUITING

NL-Leiden-LUMC, Leiden

NOT_YET_RECRUITING

NL-Maastricht-MUMC, Maastricht

NOT_YET_RECRUITING

NL-Nieuwegein-ANTONIUS, Nieuwegein

NOT_YET_RECRUITING

NL-Nijmegen-RADBOUDUMC, Nijmegen

NOT_YET_RECRUITING

NL-Rotterdam-ERASMUSMC, Rotterdam

NOT_YET_RECRUITING

NL-Den Haag-HAGA, The Hague

NOT_YET_RECRUITING

NL-Utrecht-UMCUTRECHT, Utrecht

NOT_YET_RECRUITING

NL-Zwolle-ISALA, Zwolle

NOT_YET_RECRUITING

Belfasttrust, Belfast

NOT_YET_RECRUITING

Birmingham-QE, Birmingham

NOT_YET_RECRUITING

Blackpool Victoria, Blackpool

NOT_YET_RECRUITING

UH Bristol, Bristol

NOT_YET_RECRUITING

University Hospital of Wales, Cardiff

NOT_YET_RECRUITING

Beatson West of Scotland Cancer Centre, Glasgow

NOT_YET_RECRUITING

St. James UH, Leeds

NOT_YET_RECRUITING

University Hospitals of Leicester NHS Trust, Leicester

NOT_YET_RECRUITING

University of Liverpool, Liverpool

NOT_YET_RECRUITING

King's College Hospital, London

NOT_YET_RECRUITING

St Bartholomew's Hospital, London

NOT_YET_RECRUITING

Christie NHS Foundation Trust, Manchester

NOT_YET_RECRUITING

The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle

NOT_YET_RECRUITING

Nottingham University Hospitals NHS Trust, Nottingham

NOT_YET_RECRUITING

Churchill Hospital, Oxford, Oxford

NOT_YET_RECRUITING

Southampton General Hospital, Southampton

NOT_YET_RECRUITING

The Royal Marsden NHSFT, Sutton

NOT_YET_RECRUITING

New cross hospital wolverhampton, Wolverhampton

All Listed Sponsors
collaborator

German-Austrian Acute Myeloid Leukemia Study Group

UNKNOWN

collaborator

United Kingdom AML Research Network

UNKNOWN

lead

Stichting Hemato-Oncologie voor Volwassenen Nederland

OTHER