NCT06651255View on ClinicalTrials.gov

Algorithm-based Management to Reduce the Recurrence of GI Bleeding and Severe Epistaxis in Von Willebrand Disease

NANot yet recruitingINTERVENTIONAL
Enrollment

66

Participants

Timeline

Start Date

April 30, 2025

Primary Completion Date

April 30, 2034

Study Completion Date

December 6, 2034

Conditions
Von Willebrand Disease (VWD)
Interventions
PROCEDURE

Optimized management

systematic gastrointestinal and nasal endoscopic exploration, local endoscopic treatment whenever applicable,prophylaxis with stepwise dose escalation of VWF concentrate and use of antiangiogenic drugs in patients with severe GI angiodysplasia-related bleeding

PROCEDURE

Standard of care management

Standard of care management

Trial Locations (17)

13005

AP-HM Hôpital Timone, Marseille

14000

CHU Caen, Caen

21000

CHU Dijon, Dijon

29200

CHRU Brest, Brest

31000

CHU Toulouse, Toulouse

34000

CHU Montpellier, Montpellier

35000

CHU Rennes, Rennes

37000

CHU Tours, Tours

44000

CHU Nantes, Nantes

59000

CHU Lille, Lille

63000

CHU Clermont-Ferrand, Clermont-Ferrand

67000

CHU Strasbourg, Strasbourg

69500

Hôpital cardiologique Louis Pradel, Bron

73000

CH Chambery, Chambéry

76000

CHU Rouen, Rouen

80000

CHU Amiens, Amiens

94270

AP-HP Hôpital Kremlin Bicetre, Le Kremlin-Bicêtre

All Listed Sponsors
lead

University Hospital, Lille

OTHER

NCT06651255 - Algorithm-based Management to Reduce the Recurrence of GI Bleeding and Severe Epistaxis in Von Willebrand Disease | Biotech Hunter | Biotech Hunter