NCT06649812View on ClinicalTrials.gov

Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

October 7, 2025

Primary Completion Date

September 1, 2027

Study Completion Date

September 1, 2027

Conditions
High Grade B-Cell Lymphoma With MYC and BCL6 RearrangementsRecurrent Diffuse Large B-Cell LymphomaRecurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell TypeRecurrent Diffuse Large B-Cell Lymphoma, Not Otherwise SpecifiedRecurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 RearrangementsRecurrent High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 RearrangementsRecurrent High Grade B-Cell Lymphoma, Not Otherwise SpecifiedRecurrent T-Cell/Histiocyte-Rich Large B-Cell LymphomaRefractory Diffuse Large B-Cell LymphomaRefractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell TypeRefractory Diffuse Large B-Cell Lymphoma, Not Otherwise SpecifiedRefractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 RearrangementsRefractory High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 RearrangementsRefractory High Grade B-Cell Lymphoma, Not Otherwise SpecifiedRefractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
Interventions
PROCEDURE

Biopsy Procedure

Undergo optional tumor biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Bone Marrow Aspiration

Undergo bone marrow aspiration and biopsy

PROCEDURE

Bone Marrow Biopsy

Undergo bone marrow aspiration and biopsy

PROCEDURE

Computed Tomography

Undergo CT

DRUG

Ibrutinib

Given PO

DRUG

Lenalidomide

Given PO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

BIOLOGICAL

Obinutuzumab

Given IV

PROCEDURE

Positron Emission Tomography

Undergo PET

DRUG

Prednisone

Given PO

DRUG

Venetoclax

Given PO

Trial Locations (48)

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

20892

RECRUITING

National Institutes of Health Clinical Center, Bethesda

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

45069

SUSPENDED

University of Cincinnati Cancer Center-West Chester, West Chester

45219

SUSPENDED

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

50036

RECRUITING

McFarland Clinic - Boone, Boone

50129

RECRUITING

McFarland Clinic - Jefferson, Jefferson

50158

RECRUITING

McFarland Clinic - Marshalltown, Marshalltown

50501

RECRUITING

McFarland Clinic - Trinity Cancer Center, Fort Dodge

52403

RECRUITING

Mercy Hospital, Cedar Rapids

RECRUITING

Oncology Associates at Mercy Medical Center, Cedar Rapids

53066

RECRUITING

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53149

RECRUITING

ProHealth D N Greenwald Center, Mukwonago

53188

RECRUITING

UW Cancer Center at ProHealth Care, Waukesha

59101

RECRUITING

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

59804

RECRUITING

Community Medical Center, Missoula

60026

RECRUITING

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

RECRUITING

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

RECRUITING

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

RECRUITING

Northwestern Medicine Cancer Center Delnor, Geneva

60462

RECRUITING

Northwestern Medicine Orland Park, Orland Park

60523

RECRUITING

Northwestern Medicine Oak Brook, Oak Brook

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

RECRUITING

Northwestern University, Chicago

61761

RECRUITING

Carle BroMenn Medical Center, Normal

RECRUITING

Carle Cancer Institute Normal, Normal

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

Memorial Hospital East, Shiloh

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

70121

RECRUITING

Ochsner Medical Center Jefferson, New Orleans

83814

RECRUITING

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

RECRUITING

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

RECRUITING

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

85719

RECRUITING

Banner University Medical Center - Tucson, Tucson

RECRUITING

University of Arizona Cancer Center-North Campus, Tucson

06520

RECRUITING

Yale University, New Haven

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH