120
Participants
Start Date
November 27, 2024
Primary Completion Date
February 28, 2027
Study Completion Date
June 30, 2027
bedaquiline
400 milligrams (mg) daily for 2 weeks(w), then 200mg three times a week for 22 weeks (w)
delamanid
"* for participants weighing up to 33.9 kilograms (kg): 50mg two times a day for 24w~* for participants weighing 34kg or above: 100mg two times a day for 8w, then 200mg daily for 16w"
linezolid
"* for participants weighing up to 33.9kg: 450mg daily;~* for participants weighing 34kg or above: 600mg daily; for 24w if a negative culture is obtained from sputum collected at 16w, or else for 36w"
Levofloxacin
"Only for participants with confirmed fluoroquinolone-susceptible TB or unknown fluoroquinolone susceptibility:~* for participants weighing up to 33.9kg: 500mg daily~* for participants weighing 34kg to 49.9kg: 750 daily~* for participants weighing 50kg or above: 1000mg daily for 24w if a negative culture is obtained from sputum collected at 16w, or else for 36w"
Clofazimine
"Only for participants with confirmed fluoroquinolone-resistant TB or unknown fluoroquinolone susceptibility:~100mg daily, for 24w if a negative culture is obtained from sputum collected at 16w, or else for 36w"
Anhui Chest Hospital, Hefei
The 8th Medical Center of Chinese PLA General Hospital, Beijing
The First Affiliated Hospital of Xiamen University, Xiamen
The Fourth People's Hospital of Nanning, Nanning
Liupanshui Third People's Hospital, Liupanshui
Hebei Chest Hospital, Shijiazhuang
The Fifth Hospital of Shijiazhuang, Shijiazhuang
Infectious Disease Hospital of Heilongjiang Province, Harbin
Jiamusi Tuberculosis Hospital(Jiamusi Cancer Hospital), Jiamusi
Harbin Chest Hospital, Harbin
Luoyang Center Hospital, Luoyang
The First Affiliated Hospital of Xinxiang Medical University, Xinxiang
Henan Chest Hospital, Zhengzhou
Henan Infectious Disease Hospital, Zhengzhou
Wuhan Pulmonary Hospital，Wuhan Tuberculosis Prevention and Control Institute, Wuhan
Changsha Central Hospital, Changsha
Hulunbuir Infectious Disease Hospital, Hulunbuir
The Second Hospital of Nanjing, Nanjing
Jiangxi Chest Hospital, Nanchang
Infectious Disease Hospital of Changchun, Changchun
Jilin Tuberculosis Hospital, Jilin
Shenyang Chest Hospital, Shenyang
Xi'an Chest Hospital, Xi'an
Shandong Public Health Clinical Center, Shandong University, Jinan
Linyi People Hospital, Linyi
Qingdao Chest Hospital, Qingdao
Weifang No.2 People's Hospital, Weifang
Yantai Qishan Hospital, Yantai
Shanxi Medical University Affiliated Chest Hospital, Taiyuan
Public Health Clinical Center of Chengdu, Chengdu
Tianjin Haihe Hospital, Tianjin
Wenzhou Central Hospital, Wenzhou
Beijing Chest Hospital, Beijing
Huashan Hospital, Shanghai
Beijing Chest Hospital
OTHER
Huashan Hospital
OTHER