NCT06649058View on ClinicalTrials.gov

EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active

PHASE2RecruitingINTERVENTIONAL
Enrollment

316

Participants

Timeline

Start Date

February 14, 2025

Primary Completion Date

September 30, 2028

Study Completion Date

September 30, 2030

Conditions
Brain Metastases
Interventions
OTHER

Systemic Therapy

Participants will receive systemic therapy as a standard of care therapeutic option

RADIATION

Stereotactic Radiosurgery

Participants will receive systemic therapy as a standard of care therapeutic option

Trial Locations (1)

77030

RECRUITING

The University of Texas MD Anderson Cancer Center, Houston

All Listed Sponsors
lead

M.D. Anderson Cancer Center

OTHER