110
Participants
Start Date
March 21, 2025
Primary Completion Date
March 31, 2029
Study Completion Date
March 31, 2029
Biospecimen Collection
Undergo collection of blood samples
Biospecimen Collection
Tumor tissue is collected and centrally reviewed by a study pathologist
Bone Scan
Undergo bone scan
Computed Tomography
Undergo CT
Cyclophosphamide
Given IV
Dactinomycin
Given IV
Dexrazoxane
Given IV
Doxorubicin
Given IV
Echocardiography Test
Undergo ECHO
Ifosfamide
Given IV
Magnetic Resonance Imaging
Undergo MRI
Multigated Acquisition Scan
Undergo MUGA
Patient Observation
Undergo observation
Positron Emission Tomography
Undergo PET
Topotecan
Given IV
Ultrasound Imaging
Undergo ultrasound
Vincristine
Given IV
RECRUITING
Montefiore Medical Center - Moses Campus, The Bronx
RECRUITING
New York Medical College, Valhalla
RECRUITING
Albany Medical Center, Albany
RECRUITING
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
RECRUITING
Children's Hospital of Philadelphia, Philadelphia
RECRUITING
Alfred I duPont Hospital for Children, Wilmington
RECRUITING
Children's National Medical Center, Washington D.C.
RECRUITING
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
RECRUITING
University of Virginia Cancer Center, Charlottesville
RECRUITING
Children's Hospital of The King's Daughters, Norfolk
RECRUITING
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
RECRUITING
Duke University Medical Center, Durham
RECRUITING
BI-LO Charities Children's Cancer Center, Greenville
RECRUITING
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
RECRUITING
Nemours Children's Clinic-Jacksonville, Jacksonville
RECRUITING
Arnold Palmer Hospital for Children, Orlando
RECRUITING
Nemours Children's Hospital, Orlando
RECRUITING
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
RECRUITING
Golisano Children's Hospital of Southwest Florida, Fort Myers
RECRUITING
Children's Hospital of Alabama, Birmingham
RECRUITING
The Children's Hospital at TriStar Centennial, Nashville
RECRUITING
Saint Jude Children's Research Hospital, Memphis
RECRUITING
University of Mississippi Medical Center, Jackson
RECRUITING
Norton Children's Hospital, Louisville
NOT_YET_RECRUITING
University of Kentucky/Markey Cancer Center, Lexington
RECRUITING
Nationwide Children's Hospital, Columbus
RECRUITING
Rainbow Babies and Childrens Hospital, Cleveland
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
RECRUITING
Dayton Children's Hospital, Dayton
RECRUITING
Riley Hospital for Children, Indianapolis
RECRUITING
C S Mott Children's Hospital, Ann Arbor
RECRUITING
Children's Hospital of Michigan, Detroit
RECRUITING
Bronson Methodist Hospital, Kalamazoo
RECRUITING
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
RECRUITING
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
RECRUITING
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
RECRUITING
Mayo Clinic in Rochester, Rochester
RECRUITING
Lurie Children's Hospital-Chicago, Chicago
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
Children's Mercy Hospitals and Clinics, Kansas City
RECRUITING
Children's Hospital and Medical Center of Omaha, Omaha
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
Children's Hospital New Orleans, New Orleans
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
RECRUITING
Children's Hospital of San Antonio, San Antonio
RECRUITING
Methodist Children's Hospital of South Texas, San Antonio
RECRUITING
Dell Children's Medical Center of Central Texas, Austin
RECRUITING
Children's Hospital Colorado, Aurora
RECRUITING
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
RECRUITING
Primary Children's Hospital, Salt Lake City
RECRUITING
Phoenix Childrens Hospital, Phoenix
RECRUITING
Loma Linda University Medical Center, Loma Linda
RECRUITING
Valley Children's Hospital, Madera
RECRUITING
Kaiser Permanente-Oakland, Oakland
RECRUITING
Oregon Health and Science University, Portland
NOT_YET_RECRUITING
Seattle Children's Hospital, Seattle
RECRUITING
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
RECRUITING
Arkansas Children's Hospital, Little Rock
RECRUITING
Dana-Farber Cancer Institute, Boston
RECRUITING
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
RECRUITING
Saint Joseph's Regional Medical Center, Paterson
RECRUITING
IWK Health Centre, Halifax
Children's Oncology Group
NETWORK